Tumour cell PD-L1 expression is prognostic in patients with malignant pleural effusion: the impact of C-reactive protein and immune-checkpoint inhibition

Malignant pleural effusion (MPE) confers dismal prognosis and has limited treatment options. While immune-checkpoint inhibition (ICI) proved clinical efficacy in a variety of malignancies, data on the prognostic role of PD-L1 in MPE is scarce. We retrospectively studied PD-L1 tumour proportion score...

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Veröffentlicht in:	Scientific reports 2020-04, Vol.10 (1), p.5784, Article 5784
Hauptverfasser:	Ghanim, Bahil, Rosenmayr, Anna, Stockhammer, Paul, Vogl, Melanie, Celik, Ali, Bas, Aynur, Kurul, Ismail Cuneyt, Akyurek, Nalan, Varga, Alexander, Plönes, Till, Bankfalvi, Agnes, Hager, Thomas, Schuler, Martin, Hackner, Klaus, Errhalt, Peter, Scheed, Axel, Seebacher, Gernot, Hegedus, Balazs, Stubenberger, Elisabeth, Aigner, Clemens
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1612 631/67/1641 631/67/322 631/67/580 Adult Aged Aged, 80 and over Antineoplastic Agents, Immunological - therapeutic use B7-H1 Antigen - analysis Biomarkers C-reactive protein C-Reactive Protein - analysis Female Humanities and Social Sciences Humans Immunotherapy Lung cancer Lung Neoplasms - blood Lung Neoplasms - diagnosis Lung Neoplasms - therapy Male Medical prognosis Mesothelioma Mesothelioma, Malignant - blood Mesothelioma, Malignant - diagnosis Mesothelioma, Malignant - therapy Middle Aged multidisciplinary Multivariate analysis Patients PD-L1 protein Pleural effusion Pleural Effusion, Malignant - blood Pleural Effusion, Malignant - diagnosis Pleural Effusion, Malignant - therapy Prognosis Retrospective Studies Science Science (multidisciplinary) Tumors
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