Safety and immunogenicity of mammalian cell derived and Modified Vaccinia Ankara vectored African swine fever subunit antigens in swine

•Reverse vaccinology was applied to identify and rank ASFV immunogenic candidates .•Selected ASFV immunogenic candidate proteins were expressed in HEK-293 mammalian cells and MVA constructs .•Immunizations with antigens purified from HEK-293 cells and MVA constructs in swine were safe .•Immunization...

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Veröffentlicht in:	Veterinary immunology and immunopathology 2017-03, Vol.185, p.20-33
Hauptverfasser:	Lopera-Madrid, Jaime, Osorio, Jorge E., He, Yongqun, Xiang, Zuoshuang, Adams, L. Garry, Laughlin, Richard C., Mwangi, Waithaka, Subramanya, Sandesh, Neilan, John, Brake, David, Burrage, Thomas G., Brown, William Clay, Clavijo, Alfonso, Bounpheng, Mangkey A.
Format:	Artikel
Sprache:	eng
Schlagworte:	African swine fever African Swine Fever - immunology African Swine Fever - prevention & control African swine fever virus African Swine Fever Virus - genetics African Swine Fever Virus - immunology Animals antibodies Antibodies, Viral - blood antigens Antigens, Viral - genetics Antigens, Viral - immunology fluorescent antibody technique Genetic Vectors Genome, Viral HEK-293 HEK293 Cells Humans immunization Immunogenicity, Vaccine interferon-gamma kidneys macrophages Male MVA Recombinant protein expression Reverse vaccinology Swine T-lymphocytes T-Lymphocytes - immunology Vaccine development Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccinia virus Vaccinia virus - genetics Viral Vaccines - genetics Viral Vaccines - immunology
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