RNA interference: from gene silencing to gene-specific therapeutics

In the past 4 years, RNA interference (RNAi) has become widely used as an experimental tool to analyse the function of mammalian genes, both in vitro and in vivo. By harnessing an evolutionary conserved endogenous biological pathway, first identified in plants and lower organisms, double-stranded RN...

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Veröffentlicht in:	Pharmacology & therapeutics (Oxford) 2005-08, Vol.107 (2), p.222-239
Hauptverfasser:	Leung, Ray K M, Whittaker, Paul A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Communicable Diseases - drug therapy Drug Design Gene Silencing - drug effects Gene Silencing - physiology Humans Neoplasms - drug therapy Neoplasms - genetics Respiratory Tract Diseases - drug therapy RNA Interference - drug effects RNA Interference - physiology RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics RNA, Small Interfering - therapeutic use
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