The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity

Bats harbor many viruses asymptomatically, including several notorious for causing extreme virulence in humans. To identify differences between antiviral mechanisms in humans and bats, we sequenced, assembled, and analyzed the genome of Rousettus aegyptiacus, a natural reservoir of Marburg virus and...

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Veröffentlicht in:	Cell 2018-05, Vol.173 (5), p.1098-1110.e18
Hauptverfasser:	Pavlovich, Stephanie S., Lovett, Sean P., Koroleva, Galina, Guito, Jonathan C., Arnold, Catherine E., Nagle, Elyse R., Kulcsar, Kirsten, Lee, Albert, Thibaud-Nissen, Françoise, Hume, Adam J., Mühlberger, Elke, Uebelhoer, Luke S., Towner, Jonathan S., Rabadan, Raul, Sanchez-Lockhart, Mariano, Kepler, Thomas B., Palacios, Gustavo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals antiviral immunity Cell Line Chiroptera Chiroptera - classification Chiroptera - genetics Chiroptera - immunology Chromosome Mapping Disease Reservoirs - virology Egypt evolution Evolution, Molecular filovirus Genetic Variation Genome Histocompatibility Antigens Class I - classification Histocompatibility Antigens Class I - genetics Humans immunity Immunity, Innate - genetics innate immunity Interferon Type I - classification Interferon Type I - genetics interferons major histocompatibility complex Marburg marburgvirus Marburg Virus Disease - immunology Marburg Virus Disease - pathology Marburgvirus - physiology natural killer cell receptors natural killer cells NK Cell Lectin-Like Receptor Subfamily C - chemistry NK Cell Lectin-Like Receptor Subfamily C - classification NK Cell Lectin-Like Receptor Subfamily C - genetics NK Cell Lectin-Like Receptor Subfamily D - chemistry NK Cell Lectin-Like Receptor Subfamily D - classification NK Cell Lectin-Like Receptor Subfamily D - genetics Phylogeny receptors Rousettus Sequence Alignment type I interferon virulence viruses
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