A mature and fusogenic form of the Nipah virus fusion protein requires proteolytic processing by cathepsin L

The Nipah virus fusion (F) protein is proteolytically processed to F1 + F2 subunits. We demonstrate here that cathepsin L is involved in this important maturation event. Cathepsin inhibitors ablated cleavage of Nipah F. Proteolytic processing of Nipah F and fusion activity was dramatically reduced i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2006-03, Vol.346 (2), p.251-257
Hauptverfasser:	Pager, Cara Theresia, Craft, Willie Warren, Patch, Jared, Dutch, Rebecca Ellis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cathepsin B - metabolism Cathepsin L cathepsins Cathepsins - antagonists & inhibitors Cathepsins - metabolism Cell Fusion Chlorocebus aethiops Cricetinae Cysteine Endopeptidases - metabolism endosomes Enzyme Inhibitors - pharmacology Fusion protein Gene Silencing human health Nipah Nipah virus Nipah Virus - physiology Paramyxoviridae Protein Processing, Post-Translational proteolysis Proteolytic processing swine diseases Vero Cells viral fusion proteins Viral Fusion Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!