Two-amino acids change in the nsp4 of SARS coronavirus abolishes viral replication

Infection with coronavirus rearranges the host cell membrane to assemble a replication/transcription complex in which replication of the viral genome and transcription of viral mRNA occur. Although coexistence of nsp3 and nsp4 is known to cause membrane rearrangement, the mechanisms underlying the i...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2017-10, Vol.510, p.165-174
Hauptverfasser:	Sakai, Yusuke, Kawachi, Kengo, Terada, Yutaka, Omori, Hiroko, Matsuura, Yoshiharu, Kamitani, Wataru
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Coronavirus DNA Mutational Analysis Nsp4 Protein Interaction Mapping SARS Virus - genetics SARS Virus - physiology Severe acute respiratory syndrome Viral Nonstructural Proteins - genetics Viral replication Virus Replication
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