MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling

MDM2 and MDMX, negative regulators of the tumor suppressor p53, can work separately and as a heteromeric complex to restrain p53's functions. MDM2 also has pro-oncogenic roles in cells, tissues, and animals that are independent of p53. There is less information available about p53-independent r...

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Veröffentlicht in:	Genes & development 2020-04, Vol.34 (7-8), p.526-543
Hauptverfasser:	Venkatesh, Divya, O'Brien, Nicholas A, Zandkarimi, Fereshteh, Tong, David R, Stokes, Michael E, Dunn, Denise E, Kengmana, Everett S, Aron, Allegra T, Klein, Alyssa M, Csuka, Joleen M, Moon, Sung-Hwan, Conrad, Marcus, Chang, Christopher J, Lo, Donald C, D'Alessandro, Angelo, Prives, Carol, Stockwell, Brent R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Brain - physiopathology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Ferroptosis - genetics Glioblastoma - physiopathology HCT116 Cells Humans Lipid Metabolism - genetics Mutation PPAR alpha - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors Proto-Oncogene Proteins c-mdm2 - genetics Proto-Oncogene Proteins c-mdm2 - metabolism Rats Research Paper RNA Interference Tumor Suppressor Protein p53 - metabolism Ubiquinone - analogs & derivatives Ubiquinone - metabolism
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