Veterinary vaccine development from an industrial perspective
Veterinary vaccines currently available in Europe and in other parts of the world are developed by the veterinary pharmaceutical industry. The development of a vaccine for veterinary use is an economic endeavour that takes many years. There are many obstacles along the path to the successful develop...
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| Veröffentlicht in: | The veterinary journal (1997) 2008-10, Vol.178 (1), p.7-20 |
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| container_title | The veterinary journal (1997) |
| container_volume | 178 |
| creator | Heldens, J.G.M. Patel, J.R. Chanter, N. ten Thij, G.J. Gravendijck, M. Schijns, V.E.J.C. Langen, A. Schetters, Th.P.M. |
| description | Veterinary vaccines currently available in Europe and in other parts of the world are developed by the veterinary pharmaceutical industry. The development of a vaccine for veterinary use is an economic endeavour that takes many years. There are many obstacles along the path to the successful development and launch of a vaccine. The industrial development of a vaccine for veterinary use usually starts after the proof of concept that is based on robust academic research. A vaccine can only be made available to the veterinary community once marketing authorisation has been granted by the veterinary authorities.
This review gives a brief description of the regulatory requirements which have to be fulfilled before a vaccine can be admitted to the market. Vaccines have to be produced in a quality controlled environment to guarantee delivery of a product of consistent quality with well defined animal and consumer safety and efficacy characteristics. The regulatory and manufacturing legislative framework in which the development takes place is described, as well as the trend in developments in production systems. Recent developments in bacterial, viral and parasite vaccine research and development are also addressed and the development of novel adjuvants that use the expanding knowledge of immunology and disease pathology are described. |
| doi_str_mv | 10.1016/j.tvjl.2007.11.009 |
| format | Article |
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This review gives a brief description of the regulatory requirements which have to be fulfilled before a vaccine can be admitted to the market. Vaccines have to be produced in a quality controlled environment to guarantee delivery of a product of consistent quality with well defined animal and consumer safety and efficacy characteristics. The regulatory and manufacturing legislative framework in which the development takes place is described, as well as the trend in developments in production systems. Recent developments in bacterial, viral and parasite vaccine research and development are also addressed and the development of novel adjuvants that use the expanding knowledge of immunology and disease pathology are described.</description><identifier>ISSN: 1090-0233</identifier><identifier>EISSN: 1532-2971</identifier><identifier>DOI: 10.1016/j.tvjl.2007.11.009</identifier><identifier>PMID: 18313956</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>animal diseases ; Animal Diseases - prevention & control ; Animals ; bacterial infections ; biomedical research ; disease control ; Drug Industry - economics ; Drug Industry - organization & administration ; Europe ; Good manufacturing practice (GMP) ; good manufacturing practices ; Industry ; laws and regulations ; literature reviews ; parasitoses ; process control ; process monitoring ; production technology ; quality control ; Regulatory ; therapeutics ; vaccination ; Vaccine ; vaccine adjuvants ; vaccine development ; vaccines ; Vaccines - immunology ; veterinary medicine ; viral diseases of animals and humans</subject><ispartof>The veterinary journal (1997), 2008-10, Vol.178 (1), p.7-20</ispartof><rights>2007 Elsevier Ltd</rights><rights>Copyright © 2007 Elsevier Ltd. All rights reserved. 2007 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-2eea978e5b24a599fe299aa87b5c2f1efc9782810871c0c864a2db4d8601205d3</citedby><cites>FETCH-LOGICAL-c477t-2eea978e5b24a599fe299aa87b5c2f1efc9782810871c0c864a2db4d8601205d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tvjl.2007.11.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18313956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heldens, J.G.M.</creatorcontrib><creatorcontrib>Patel, J.R.</creatorcontrib><creatorcontrib>Chanter, N.</creatorcontrib><creatorcontrib>ten Thij, G.J.</creatorcontrib><creatorcontrib>Gravendijck, M.</creatorcontrib><creatorcontrib>Schijns, V.E.J.C.</creatorcontrib><creatorcontrib>Langen, A.</creatorcontrib><creatorcontrib>Schetters, Th.P.M.</creatorcontrib><title>Veterinary vaccine development from an industrial perspective</title><title>The veterinary journal (1997)</title><addtitle>Vet J</addtitle><description>Veterinary vaccines currently available in Europe and in other parts of the world are developed by the veterinary pharmaceutical industry. The development of a vaccine for veterinary use is an economic endeavour that takes many years. There are many obstacles along the path to the successful development and launch of a vaccine. The industrial development of a vaccine for veterinary use usually starts after the proof of concept that is based on robust academic research. A vaccine can only be made available to the veterinary community once marketing authorisation has been granted by the veterinary authorities.
This review gives a brief description of the regulatory requirements which have to be fulfilled before a vaccine can be admitted to the market. Vaccines have to be produced in a quality controlled environment to guarantee delivery of a product of consistent quality with well defined animal and consumer safety and efficacy characteristics. The regulatory and manufacturing legislative framework in which the development takes place is described, as well as the trend in developments in production systems. Recent developments in bacterial, viral and parasite vaccine research and development are also addressed and the development of novel adjuvants that use the expanding knowledge of immunology and disease pathology are described.</description><subject>animal diseases</subject><subject>Animal Diseases - prevention & control</subject><subject>Animals</subject><subject>bacterial infections</subject><subject>biomedical research</subject><subject>disease control</subject><subject>Drug Industry - economics</subject><subject>Drug Industry - organization & administration</subject><subject>Europe</subject><subject>Good manufacturing practice (GMP)</subject><subject>good manufacturing practices</subject><subject>Industry</subject><subject>laws and regulations</subject><subject>literature reviews</subject><subject>parasitoses</subject><subject>process control</subject><subject>process monitoring</subject><subject>production technology</subject><subject>quality control</subject><subject>Regulatory</subject><subject>therapeutics</subject><subject>vaccination</subject><subject>Vaccine</subject><subject>vaccine adjuvants</subject><subject>vaccine development</subject><subject>vaccines</subject><subject>Vaccines - immunology</subject><subject>veterinary medicine</subject><subject>viral diseases of animals and humans</subject><issn>1090-0233</issn><issn>1532-2971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EoqXwBzhATr0lnbHzZQmQUAUtUiUObbmOvM6keJXEwc5G6r-vV7vi48LJluaZ168eC_EWoUDA-mJbLOt2KCRAUyAWAPqZOMVKyVzqBp-nO2jIQSp1Il7FuIVElKV8KU6wVah0VZ-Kjz944eAmEx6z1VjrJs46Xnnw88jTkvXBj5mZMjd1u7gEZ4Zs5hBntotb-bV40Zsh8pvjeSbuv365u7zOb75ffbv8fJPbsmmWXDIb3bRcbWRpKq17llob0zabysoeubdpKluEtkELtq1LI7tN2bU1oISqU2fi0yF33m1G7mxqFsxAc3BjKk7eOPp3Mrmf9OBXajCFVnUKOD8GBP9rx3Gh0UXLw2Am9rtIta5kLVuVQHkAbfAxBu5_P4JAe-u0pb112lsnREpO09K7v-v9WTlqTsD7A9AbT-YhuEj3txJQQfourXAf8eFAcNK4Og4UrePJcudCck2dd_9r8ASldJ6G</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Heldens, J.G.M.</creator><creator>Patel, J.R.</creator><creator>Chanter, N.</creator><creator>ten Thij, G.J.</creator><creator>Gravendijck, M.</creator><creator>Schijns, V.E.J.C.</creator><creator>Langen, A.</creator><creator>Schetters, Th.P.M.</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20081001</creationdate><title>Veterinary vaccine development from an industrial perspective</title><author>Heldens, J.G.M. ; Patel, J.R. ; Chanter, N. ; ten Thij, G.J. ; Gravendijck, M. ; Schijns, V.E.J.C. ; Langen, A. ; Schetters, Th.P.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-2eea978e5b24a599fe299aa87b5c2f1efc9782810871c0c864a2db4d8601205d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>animal diseases</topic><topic>Animal Diseases - prevention & control</topic><topic>Animals</topic><topic>bacterial infections</topic><topic>biomedical research</topic><topic>disease control</topic><topic>Drug Industry - economics</topic><topic>Drug Industry - organization & administration</topic><topic>Europe</topic><topic>Good manufacturing practice (GMP)</topic><topic>good manufacturing practices</topic><topic>Industry</topic><topic>laws and regulations</topic><topic>literature reviews</topic><topic>parasitoses</topic><topic>process control</topic><topic>process monitoring</topic><topic>production technology</topic><topic>quality control</topic><topic>Regulatory</topic><topic>therapeutics</topic><topic>vaccination</topic><topic>Vaccine</topic><topic>vaccine adjuvants</topic><topic>vaccine development</topic><topic>vaccines</topic><topic>Vaccines - immunology</topic><topic>veterinary medicine</topic><topic>viral diseases of animals and humans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heldens, J.G.M.</creatorcontrib><creatorcontrib>Patel, J.R.</creatorcontrib><creatorcontrib>Chanter, N.</creatorcontrib><creatorcontrib>ten Thij, G.J.</creatorcontrib><creatorcontrib>Gravendijck, M.</creatorcontrib><creatorcontrib>Schijns, V.E.J.C.</creatorcontrib><creatorcontrib>Langen, A.</creatorcontrib><creatorcontrib>Schetters, Th.P.M.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The veterinary journal (1997)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heldens, J.G.M.</au><au>Patel, J.R.</au><au>Chanter, N.</au><au>ten Thij, G.J.</au><au>Gravendijck, M.</au><au>Schijns, V.E.J.C.</au><au>Langen, A.</au><au>Schetters, Th.P.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Veterinary vaccine development from an industrial perspective</atitle><jtitle>The veterinary journal (1997)</jtitle><addtitle>Vet J</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>178</volume><issue>1</issue><spage>7</spage><epage>20</epage><pages>7-20</pages><issn>1090-0233</issn><eissn>1532-2971</eissn><abstract>Veterinary vaccines currently available in Europe and in other parts of the world are developed by the veterinary pharmaceutical industry. The development of a vaccine for veterinary use is an economic endeavour that takes many years. There are many obstacles along the path to the successful development and launch of a vaccine. The industrial development of a vaccine for veterinary use usually starts after the proof of concept that is based on robust academic research. A vaccine can only be made available to the veterinary community once marketing authorisation has been granted by the veterinary authorities.
This review gives a brief description of the regulatory requirements which have to be fulfilled before a vaccine can be admitted to the market. Vaccines have to be produced in a quality controlled environment to guarantee delivery of a product of consistent quality with well defined animal and consumer safety and efficacy characteristics. The regulatory and manufacturing legislative framework in which the development takes place is described, as well as the trend in developments in production systems. Recent developments in bacterial, viral and parasite vaccine research and development are also addressed and the development of novel adjuvants that use the expanding knowledge of immunology and disease pathology are described.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>18313956</pmid><doi>10.1016/j.tvjl.2007.11.009</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The veterinary journal (1997), 2008-10, Vol.178 (1), p.7-20 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | animal diseases Animal Diseases - prevention & control Animals bacterial infections biomedical research disease control Drug Industry - economics Drug Industry - organization & administration Europe Good manufacturing practice (GMP) good manufacturing practices Industry laws and regulations literature reviews parasitoses process control process monitoring production technology quality control Regulatory therapeutics vaccination Vaccine vaccine adjuvants vaccine development vaccines Vaccines - immunology veterinary medicine viral diseases of animals and humans |
| title | Veterinary vaccine development from an industrial perspective |
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