Phytochemical Study on Antioxidant and Antiproliferative Activities of Moroccan Caralluma europaea Extract and Its Bioactive Compound Classes
Background. Caralluma europaea (C. europaea) is a medicinal plant used in Moroccan popular medicine. Objective of the Study. The present work was aimed at identifying the chemical composition and the antioxidant and antiproliferative activities of hydroethanolic and bioactive compound classes of C....
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-9 |
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| creator | Calarco, Anna Benbacer, Laila Bousta, Dalila Di Cristo, Francesca Amaghnouje, Amal Akbar, Riaz Ullah Said Bari, Ahmed Moussa, Samir Iben Slighoua, Meryem Bourhia, Mohammed Amrati, Fatima ez-zahra El Mzibri, Mohamed |
| description | Background. Caralluma europaea (C. europaea) is a medicinal plant used in Moroccan popular medicine. Objective of the Study. The present work was aimed at identifying the chemical composition and the antioxidant and antiproliferative activities of hydroethanolic and bioactive compound classes of C. europaea. Materials and Methods. The chemical composition was analyzed using HPLC. The antioxidant power was determined using both DPPH and FRAP assays. The antiproliferative activity was effectuated against cancerous cells using WST-1. Results. The chemical analysis showed the presence of bioactive constituents such as quercetin, myricetin, and hesperetin. The polyphenol and flavonoid contents were estimated at 51.42 mg GA/g and 20.06 mg EQ/g, respectively. The EC50 values of FRAP assay of hydroethanolic, flavonoid, saponin, and mucilage extracts were 5.196 mg/ml, 4.537 mg/ml, 3.05 mg/ml, and 6.02 mg/ml, respectively. The obtained IC50 values with the DPPH test were 1.628 mg/ml, 1.05 mg/ml, 1.94 mg/ml, and 9.674 mg/ml, respectively. Regarding MDA-MB-231, saponins were highly effective even with the lowest concentration (15.62 μg/ml). The flavonoids decreased the cell viability with IC50 values of 43.62 ± 0.06 μg/ml, whereas the hydroethanolic extract and mucilages were ineffective. Saponins were also effective against MCF-7 cells with IC50 values of 4.195 ± 0.025 μg/ml. Conclusion. The present results suggest that C. europaea may have considerable potential for the development of effective natural anticancer agents. |
| doi_str_mv | 10.1155/2020/8409718 |
| format | Article |
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Caralluma europaea (C. europaea) is a medicinal plant used in Moroccan popular medicine. Objective of the Study. The present work was aimed at identifying the chemical composition and the antioxidant and antiproliferative activities of hydroethanolic and bioactive compound classes of C. europaea. Materials and Methods. The chemical composition was analyzed using HPLC. The antioxidant power was determined using both DPPH and FRAP assays. The antiproliferative activity was effectuated against cancerous cells using WST-1. Results. The chemical analysis showed the presence of bioactive constituents such as quercetin, myricetin, and hesperetin. The polyphenol and flavonoid contents were estimated at 51.42 mg GA/g and 20.06 mg EQ/g, respectively. The EC50 values of FRAP assay of hydroethanolic, flavonoid, saponin, and mucilage extracts were 5.196 mg/ml, 4.537 mg/ml, 3.05 mg/ml, and 6.02 mg/ml, respectively. The obtained IC50 values with the DPPH test were 1.628 mg/ml, 1.05 mg/ml, 1.94 mg/ml, and 9.674 mg/ml, respectively. Regarding MDA-MB-231, saponins were highly effective even with the lowest concentration (15.62 μg/ml). The flavonoids decreased the cell viability with IC50 values of 43.62 ± 0.06 μg/ml, whereas the hydroethanolic extract and mucilages were ineffective. Saponins were also effective against MCF-7 cells with IC50 values of 4.195 ± 0.025 μg/ml. Conclusion. The present results suggest that C. europaea may have considerable potential for the development of effective natural anticancer agents.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2020/8409718</identifier><identifier>PMID: 32256660</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acids ; Analysis ; Antioxidants ; Antitumor agents ; Bioactive compounds ; Breast cancer ; Cancer therapies ; Cell viability ; Chemical composition ; Flavonoids ; Herbal medicine ; Hesperidin ; High-performance liquid chromatography ; Isoflavones ; Medicinal plants ; Medicine, Botanic ; Medicine, Herbal ; Mucilage ; Phytochemicals ; Quercetin ; Saponins</subject><ispartof>Evidence-based complementary and alternative medicine, 2020, Vol.2020 (2020), p.1-9</ispartof><rights>Copyright © 2020 Fatima ez-zahra Amrati et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Fatima ez-zahra Amrati et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Fatima ez-zahra Amrati et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-9e6923e76a959e95ea518de192bb00fcedc81597ff39018db8fb9996f22a0d003</citedby><cites>FETCH-LOGICAL-c499t-9e6923e76a959e95ea518de192bb00fcedc81597ff39018db8fb9996f22a0d003</cites><orcidid>0000-0001-5753-3834 ; 0000-0002-3148-1527 ; 0000-0002-3569-0203 ; 0000-0003-3707-8461 ; 0000-0002-4200-6158</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109577/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109577/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32256660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Mahajna, Jamal A.</contributor><contributor>Jamal A Mahajna</contributor><creatorcontrib>Calarco, Anna</creatorcontrib><creatorcontrib>Benbacer, Laila</creatorcontrib><creatorcontrib>Bousta, Dalila</creatorcontrib><creatorcontrib>Di Cristo, Francesca</creatorcontrib><creatorcontrib>Amaghnouje, Amal</creatorcontrib><creatorcontrib>Akbar, Riaz Ullah Said</creatorcontrib><creatorcontrib>Bari, Ahmed</creatorcontrib><creatorcontrib>Moussa, Samir Iben</creatorcontrib><creatorcontrib>Slighoua, Meryem</creatorcontrib><creatorcontrib>Bourhia, Mohammed</creatorcontrib><creatorcontrib>Amrati, Fatima ez-zahra</creatorcontrib><creatorcontrib>El Mzibri, Mohamed</creatorcontrib><title>Phytochemical Study on Antioxidant and Antiproliferative Activities of Moroccan Caralluma europaea Extract and Its Bioactive Compound Classes</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Background. Caralluma europaea (C. europaea) is a medicinal plant used in Moroccan popular medicine. Objective of the Study. The present work was aimed at identifying the chemical composition and the antioxidant and antiproliferative activities of hydroethanolic and bioactive compound classes of C. europaea. Materials and Methods. The chemical composition was analyzed using HPLC. The antioxidant power was determined using both DPPH and FRAP assays. The antiproliferative activity was effectuated against cancerous cells using WST-1. Results. The chemical analysis showed the presence of bioactive constituents such as quercetin, myricetin, and hesperetin. The polyphenol and flavonoid contents were estimated at 51.42 mg GA/g and 20.06 mg EQ/g, respectively. The EC50 values of FRAP assay of hydroethanolic, flavonoid, saponin, and mucilage extracts were 5.196 mg/ml, 4.537 mg/ml, 3.05 mg/ml, and 6.02 mg/ml, respectively. The obtained IC50 values with the DPPH test were 1.628 mg/ml, 1.05 mg/ml, 1.94 mg/ml, and 9.674 mg/ml, respectively. Regarding MDA-MB-231, saponins were highly effective even with the lowest concentration (15.62 μg/ml). The flavonoids decreased the cell viability with IC50 values of 43.62 ± 0.06 μg/ml, whereas the hydroethanolic extract and mucilages were ineffective. Saponins were also effective against MCF-7 cells with IC50 values of 4.195 ± 0.025 μg/ml. Conclusion. The present results suggest that C. europaea may have considerable potential for the development of effective natural anticancer agents.</description><subject>Acids</subject><subject>Analysis</subject><subject>Antioxidants</subject><subject>Antitumor agents</subject><subject>Bioactive compounds</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Cell viability</subject><subject>Chemical composition</subject><subject>Flavonoids</subject><subject>Herbal medicine</subject><subject>Hesperidin</subject><subject>High-performance liquid chromatography</subject><subject>Isoflavones</subject><subject>Medicinal plants</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Mucilage</subject><subject>Phytochemicals</subject><subject>Quercetin</subject><subject>Saponins</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkcFu1DAURSMEoqWwY40ssYShthPH8QZpGBWoVAQSILGzXpznjqvETu2kdD6Cf8bTGYayY_Vsv6OjK9-ieM7oG8aEOOWU09Omokqy5kFxzGTFFhVvmoeHs_xxVDxJ6YpSrqSUj4ujknNR1zU9Ln59WW-mYNY4OAM9-TrN3YYET5Z-cuHWdeAnAr67u48x9M5ihMndIFmaPNzkMJFgyacQgzHgyQoi9P08AME5hhEQyNntFMHsPOdTIu9cAHPnWIVhDHN-XvWQEqanxSMLfcJn-3lSfH9_9m31cXHx-cP5anmxMJVS00JhrXiJsgYlFCqBIFjTIVO8bSm1BjvTMKGktaWiedM2tlVK1ZZzoB2l5Unxducd53bINPqcsNdjdAPEjQ7g9L8b79b6MtxoyagSUmbBy70ghusZ06Svwhx9zqx52VSsrEV9j7qEHrXzNmw_YnDJ6GXNy6qqONtSr3eUiSGliPaQg1G9rVhvK9b7ijP-4n72A_yn0wy82gFr5zv46f5Th5lBC39pJqRoZPkbxlC6vQ</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Calarco, 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Study on Antioxidant and Antiproliferative Activities of Moroccan Caralluma europaea Extract and Its Bioactive Compound Classes</title><author>Calarco, Anna ; Benbacer, Laila ; Bousta, Dalila ; Di Cristo, Francesca ; Amaghnouje, Amal ; Akbar, Riaz Ullah Said ; Bari, Ahmed ; Moussa, Samir Iben ; Slighoua, Meryem ; Bourhia, Mohammed ; Amrati, Fatima ez-zahra ; El Mzibri, Mohamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-9e6923e76a959e95ea518de192bb00fcedc81597ff39018db8fb9996f22a0d003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acids</topic><topic>Analysis</topic><topic>Antioxidants</topic><topic>Antitumor agents</topic><topic>Bioactive compounds</topic><topic>Breast cancer</topic><topic>Cancer therapies</topic><topic>Cell viability</topic><topic>Chemical composition</topic><topic>Flavonoids</topic><topic>Herbal medicine</topic><topic>Hesperidin</topic><topic>High-performance liquid chromatography</topic><topic>Isoflavones</topic><topic>Medicinal plants</topic><topic>Medicine, Botanic</topic><topic>Medicine, Herbal</topic><topic>Mucilage</topic><topic>Phytochemicals</topic><topic>Quercetin</topic><topic>Saponins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calarco, Anna</creatorcontrib><creatorcontrib>Benbacer, Laila</creatorcontrib><creatorcontrib>Bousta, Dalila</creatorcontrib><creatorcontrib>Di Cristo, Francesca</creatorcontrib><creatorcontrib>Amaghnouje, Amal</creatorcontrib><creatorcontrib>Akbar, Riaz Ullah Said</creatorcontrib><creatorcontrib>Bari, Ahmed</creatorcontrib><creatorcontrib>Moussa, Samir Iben</creatorcontrib><creatorcontrib>Slighoua, Meryem</creatorcontrib><creatorcontrib>Bourhia, Mohammed</creatorcontrib><creatorcontrib>Amrati, Fatima ez-zahra</creatorcontrib><creatorcontrib>El Mzibri, 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Iben</au><au>Slighoua, Meryem</au><au>Bourhia, Mohammed</au><au>Amrati, Fatima ez-zahra</au><au>El Mzibri, Mohamed</au><au>Mahajna, Jamal A.</au><au>Jamal A Mahajna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phytochemical Study on Antioxidant and Antiproliferative Activities of Moroccan Caralluma europaea Extract and Its Bioactive Compound Classes</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Background. Caralluma europaea (C. europaea) is a medicinal plant used in Moroccan popular medicine. Objective of the Study. The present work was aimed at identifying the chemical composition and the antioxidant and antiproliferative activities of hydroethanolic and bioactive compound classes of C. europaea. Materials and Methods. The chemical composition was analyzed using HPLC. The antioxidant power was determined using both DPPH and FRAP assays. The antiproliferative activity was effectuated against cancerous cells using WST-1. Results. The chemical analysis showed the presence of bioactive constituents such as quercetin, myricetin, and hesperetin. The polyphenol and flavonoid contents were estimated at 51.42 mg GA/g and 20.06 mg EQ/g, respectively. The EC50 values of FRAP assay of hydroethanolic, flavonoid, saponin, and mucilage extracts were 5.196 mg/ml, 4.537 mg/ml, 3.05 mg/ml, and 6.02 mg/ml, respectively. The obtained IC50 values with the DPPH test were 1.628 mg/ml, 1.05 mg/ml, 1.94 mg/ml, and 9.674 mg/ml, respectively. Regarding MDA-MB-231, saponins were highly effective even with the lowest concentration (15.62 μg/ml). The flavonoids decreased the cell viability with IC50 values of 43.62 ± 0.06 μg/ml, whereas the hydroethanolic extract and mucilages were ineffective. Saponins were also effective against MCF-7 cells with IC50 values of 4.195 ± 0.025 μg/ml. Conclusion. The present results suggest that C. europaea may have considerable potential for the development of effective natural anticancer agents.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32256660</pmid><doi>10.1155/2020/8409718</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5753-3834</orcidid><orcidid>https://orcid.org/0000-0002-3148-1527</orcidid><orcidid>https://orcid.org/0000-0002-3569-0203</orcidid><orcidid>https://orcid.org/0000-0003-3707-8461</orcidid><orcidid>https://orcid.org/0000-0002-4200-6158</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Analysis Antioxidants Antitumor agents Bioactive compounds Breast cancer Cancer therapies Cell viability Chemical composition Flavonoids Herbal medicine Hesperidin High-performance liquid chromatography Isoflavones Medicinal plants Medicine, Botanic Medicine, Herbal Mucilage Phytochemicals Quercetin Saponins |
| title | Phytochemical Study on Antioxidant and Antiproliferative Activities of Moroccan Caralluma europaea Extract and Its Bioactive Compound Classes |
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