ZBP1 mediates interferon-induced necroptosis

Interferons (IFNs) play an important role in immunomodulatory and antiviral functions. IFN-induced necroptosis has been reported in cells deficient in receptor-interacting protein kinase 1 (RIPK1), Fas-associated protein with death domain (FADD), or caspase-8, but the mechanism is largely unknown. H...

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Veröffentlicht in:	Cellular & molecular immunology 2020-04, Vol.17 (4), p.356-368
Hauptverfasser:	Yang, Daowei, Liang, Yaoji, Zhao, Shubo, Ding, Yan, Zhuang, Qiuyu, Shi, Qilin, Ai, Tingting, Wu, Su-Qin, Han, Jiahuai
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/262 631/80/86 Animals Antibodies Biomedical and Life Sciences Biomedicine Caspase 8 - metabolism Caspase-8 Cell Line FADD protein Fas-Associated Death Domain Protein - metabolism Fas-associated protein Humans Immunology Immunomodulation Inflammation Interferon Interferons - pharmacology Janus Kinase 1 - metabolism Kinases Male Medical Microbiology Mice, Inbred C57BL Mice, Knockout Microbiology Mutant Proteins - metabolism Necroptosis Necroptosis - drug effects Protein Binding - drug effects Protein biosynthesis Protein Biosynthesis - drug effects Protein Domains Protein kinase Proteins Receptor-Interacting Protein Serine-Threonine Kinases - metabolism RNA-Binding Proteins - chemistry RNA-Binding Proteins - metabolism Signal Transduction - drug effects STAT1 Transcription Factor - metabolism Systemic inflammatory response syndrome Systemic Inflammatory Response Syndrome - metabolism Systemic Inflammatory Response Syndrome - pathology Tumor necrosis factor Tumor Necrosis Factor-alpha Vaccine γ-Interferon
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