Potassium depletion induces cellular conversion in the outer medullary collecting duct altering Notch signaling pathway

Potassium depletion affects AQP2 expression and the cellular composition of the kidney collecting duct. This, in turn, contributes to the development of a secondary form of nephrogenic diabetes insipidus and hypokalemic nephropathy. Here we show that after 14 days of potassium depletion, the cellula...

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Veröffentlicht in:	Scientific reports 2020-03, Vol.10 (1), p.5708-5708, Article 5708
Hauptverfasser:	Iervolino, Anna, Prosperi, Federica, De La Motte, Luigi R., Petrillo, Federica, Spagnuolo, Manuela, D’Acierno, Mariavittoria, Siccardi, Sabrina, Perna, Alessandra F., Christensen, Birgitte M., Frische, Sebastian, Capasso, Giovambattista, Trepiccione, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 59 631/443/272/1684 64 692/4022/272/1684 82 82/80 Animals Aquaporin 2 Aquaporin 2 - metabolism Collecting duct Diabetes insipidus Diabetes Insipidus, Nephrogenic - metabolism Diabetes Insipidus, Nephrogenic - pathology Down-Regulation Epithelium Humanities and Social Sciences Hypokalemia Hypokalemia - metabolism Hypokalemia - pathology Kidney Medulla - metabolism Kidney Medulla - pathology Kidney Tubules, Collecting - metabolism Kidney Tubules, Collecting - pathology Kidneys Lithium multidisciplinary Nephropathy Potassium Potassium - metabolism Rats Receptors, Notch - metabolism Science Science (multidisciplinary) Signal transduction Signal Transduction - physiology Sodium
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