Potassium depletion induces cellular conversion in the outer medullary collecting duct altering Notch signaling pathway
Potassium depletion affects AQP2 expression and the cellular composition of the kidney collecting duct. This, in turn, contributes to the development of a secondary form of nephrogenic diabetes insipidus and hypokalemic nephropathy. Here we show that after 14 days of potassium depletion, the cellula...
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| Veröffentlicht in: | Scientific reports 2020-03, Vol.10 (1), p.5708-5708, Article 5708 |
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| creator | Iervolino, Anna Prosperi, Federica De La Motte, Luigi R. Petrillo, Federica Spagnuolo, Manuela D’Acierno, Mariavittoria Siccardi, Sabrina Perna, Alessandra F. Christensen, Birgitte M. Frische, Sebastian Capasso, Giovambattista Trepiccione, Francesco |
| description | Potassium depletion affects AQP2 expression and the cellular composition of the kidney collecting duct. This, in turn, contributes to the development of a secondary form of nephrogenic diabetes insipidus and hypokalemic nephropathy. Here we show that after 14 days of potassium depletion, the cellular fraction of A-type intercalated cells increases while the fraction of principal cells decreases along the outer medullary collecting duct in rats. The intercalated cells acquired a novel distribution pattern forming rows of cells attached to each other. These morphological changes occur progressively and reverse after 7 days of recovery on normal rat chow diet. The cellular remodeling mainly occurred in the inner stripe of outer medulla similar to the previously seen effect of lithium on the collecting duct cellular profile. The cellular remodeling is associated with the appearance of cells double labelled with both specific markers of principal and type-A intercalated cells. The appearance of this cell type was associated with the downregulation of the Notch signaling via the Hes1 pathways. These results show that the epithelium of the collecting duct has a high degree of plasticity and that Notch signaling likely plays a key role during hypokalemia. |
| doi_str_mv | 10.1038/s41598-020-61882-7 |
| format | Article |
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This, in turn, contributes to the development of a secondary form of nephrogenic diabetes insipidus and hypokalemic nephropathy. Here we show that after 14 days of potassium depletion, the cellular fraction of A-type intercalated cells increases while the fraction of principal cells decreases along the outer medullary collecting duct in rats. The intercalated cells acquired a novel distribution pattern forming rows of cells attached to each other. These morphological changes occur progressively and reverse after 7 days of recovery on normal rat chow diet. The cellular remodeling mainly occurred in the inner stripe of outer medulla similar to the previously seen effect of lithium on the collecting duct cellular profile. The cellular remodeling is associated with the appearance of cells double labelled with both specific markers of principal and type-A intercalated cells. The appearance of this cell type was associated with the downregulation of the Notch signaling via the Hes1 pathways. 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This, in turn, contributes to the development of a secondary form of nephrogenic diabetes insipidus and hypokalemic nephropathy. Here we show that after 14 days of potassium depletion, the cellular fraction of A-type intercalated cells increases while the fraction of principal cells decreases along the outer medullary collecting duct in rats. The intercalated cells acquired a novel distribution pattern forming rows of cells attached to each other. These morphological changes occur progressively and reverse after 7 days of recovery on normal rat chow diet. The cellular remodeling mainly occurred in the inner stripe of outer medulla similar to the previously seen effect of lithium on the collecting duct cellular profile. The cellular remodeling is associated with the appearance of cells double labelled with both specific markers of principal and type-A intercalated cells. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iervolino, Anna</au><au>Prosperi, Federica</au><au>De La Motte, Luigi R.</au><au>Petrillo, Federica</au><au>Spagnuolo, Manuela</au><au>D’Acierno, Mariavittoria</au><au>Siccardi, Sabrina</au><au>Perna, Alessandra F.</au><au>Christensen, Birgitte M.</au><au>Frische, Sebastian</au><au>Capasso, Giovambattista</au><au>Trepiccione, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potassium depletion induces cellular conversion in the outer medullary collecting duct altering Notch signaling pathway</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-03-31</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>5708</spage><epage>5708</epage><pages>5708-5708</pages><artnum>5708</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Potassium depletion affects AQP2 expression and the cellular composition of the kidney collecting duct. This, in turn, contributes to the development of a secondary form of nephrogenic diabetes insipidus and hypokalemic nephropathy. Here we show that after 14 days of potassium depletion, the cellular fraction of A-type intercalated cells increases while the fraction of principal cells decreases along the outer medullary collecting duct in rats. The intercalated cells acquired a novel distribution pattern forming rows of cells attached to each other. These morphological changes occur progressively and reverse after 7 days of recovery on normal rat chow diet. The cellular remodeling mainly occurred in the inner stripe of outer medulla similar to the previously seen effect of lithium on the collecting duct cellular profile. The cellular remodeling is associated with the appearance of cells double labelled with both specific markers of principal and type-A intercalated cells. The appearance of this cell type was associated with the downregulation of the Notch signaling via the Hes1 pathways. These results show that the epithelium of the collecting duct has a high degree of plasticity and that Notch signaling likely plays a key role during hypokalemia.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32235870</pmid><doi>10.1038/s41598-020-61882-7</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3297-4953</orcidid><orcidid>https://orcid.org/0000-0002-4303-7327</orcidid><orcidid>https://orcid.org/0000-0002-8760-1292</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 101/1 59 631/443/272/1684 64 692/4022/272/1684 82 82/80 Animals Aquaporin 2 Aquaporin 2 - metabolism Collecting duct Diabetes insipidus Diabetes Insipidus, Nephrogenic - metabolism Diabetes Insipidus, Nephrogenic - pathology Down-Regulation Epithelium Humanities and Social Sciences Hypokalemia Hypokalemia - metabolism Hypokalemia - pathology Kidney Medulla - metabolism Kidney Medulla - pathology Kidney Tubules, Collecting - metabolism Kidney Tubules, Collecting - pathology Kidneys Lithium multidisciplinary Nephropathy Potassium Potassium - metabolism Rats Receptors, Notch - metabolism Science Science (multidisciplinary) Signal transduction Signal Transduction - physiology Sodium |
| title | Potassium depletion induces cellular conversion in the outer medullary collecting duct altering Notch signaling pathway |
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