Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases

BACKGROUNDUndifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available targeted treatments.METHODSSixty-six consecutively referred USAID patients underwen...

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Veröffentlicht in:	The Journal of clinical investigation 2020-04, Vol.130 (4), p.1669-1682
Hauptverfasser:	de Jesus, Adriana A, Hou, Yangfeng, Brooks, Stephen, Malle, Louise, Biancotto, Angelique, Huang, Yan, Calvo, Katherine R, Marrero, Bernadette, Moir, Susan, Oler, Andrew J, Deng, Zuoming, Montealegre Sanchez, Gina A, Ahmed, Amina, Allenspach, Eric, Arabshahi, Bita, Behrens, Edward, Benseler, Susanne, Bezrodnik, Liliana, Bout-Tabaku, Sharon, Brescia, AnneMarie C, Brown, Diane, Burnham, Jon M, Caldirola, Maria Soledad, Carrasco, Ruy, Chan, Alice Y, Cimaz, Rolando, Dancey, Paul, Dare, Jason, DeGuzman, Marietta, Dimitriades, Victoria, Ferguson, Ian, Ferguson, Polly, Finn, Laura, Gattorno, Marco, Grom, Alexei A, Hanson, Eric P, Hashkes, Philip J, Hedrich, Christian M, Herzog, Ronit, Horneff, Gerd, Jerath, Rita, Kessler, Elizabeth, Kim, Hanna, Kingsbury, Daniel J, Laxer, Ronald M, Lee, Pui Y, Lee-Kirsch, Min Ae, Lewandowski, Laura, Li, Suzanne, Lilleby, Vibke, Mammadova, Vafa, Moorthy, Lakshmi N, Nasrullayeva, Gulnara, O'Neil, Kathleen M, Onel, Karen, Ozen, Seza, Pan, Nancy, Pillet, Pascal, Piotto, Daniela Gp, Punaro, Marilynn G, Reiff, Andreas, Reinhardt, Adam, Rider, Lisa G, Rivas-Chacon, Rafael, Ronis, Tova, Rösen-Wolff, Angela, Roth, Johannes, Ruth, Natasha Mckerran, Rygg, Marite, Schmeling, Heinrike, Schulert, Grant, Scott, Christiaan, Seminario, Gisella, Shulman, Andrew, Sivaraman, Vidya, Son, Mary Beth, Stepanovskiy, Yuriy, Stringer, Elizabeth, Taber, Sara, Terreri, Maria Teresa, Tifft, Cynthia, Torgerson, Troy, Tosi, Laura, Van Royen-Kerkhof, Annet, Wampler Muskardin, Theresa, Canna, Scott W, Goldbach-Mansky, Raphaela
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Alveoli Antibodies Autoantibodies Autoimmune Diseases - genetics Autoimmune Diseases - immunology Autoimmunity Basal ganglia Binding sites Biological response modifiers Biomedical research Cell activation Clinical Medicine Criminal investigation Cytokines Dermatomyositis Diseases Epidemiology Female Frameshift mutation Genes Health aspects Humans Immunoglobulins Immunologic factors Inflammation Interferon Interferon Type I - genetics Interferon Type I - immunology Interleukin 18 Interleukin-18 - genetics Interleukin-18 - immunology Laboratories Leukocytes (neutrophilic) Lung diseases Lupus Macrophage Activation Syndrome - genetics Macrophage Activation Syndrome - immunology Macrophages Male Mutation Myositis NF-κB protein Novels Panniculitis - genetics Panniculitis - immunology Pathogenesis Pharmaceutical industry Phenotypes Pulmonary alveolar proteinosis Pulmonary Alveolar Proteinosis - genetics Pulmonary Alveolar Proteinosis - immunology Research funding Respiratory tract diseases
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