O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth

Cancer cells are known to adopt aerobic glycolysis in order to fuel tumor growth, but the molecular basis of this metabolic shift remains largely undefined. O-GlcNAcase (OGA) is an enzyme harboring O-linked β-N-acetylglucosamine (O-GlcNAc) hydrolase and cryptic lysine acetyltransferase activities. H...

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Veröffentlicht in:	Oncogene 2020-01, Vol.39 (3), p.560-573
Hauptverfasser:	Singh, Jay Prakash, Qian, Kevin, Lee, Jeong-Sang, Zhou, Jinfeng, Han, Xuemei, Zhang, Bichen, Ong, Qunxiang, Ni, Weiming, Jiang, Mingzuo, Ruan, Hai-Bin, Li, Min-Dian, Zhang, Kaisi, Ding, Zhaobing, Lee, Philip, Singh, Kamini, Wu, Jing, Herzog, Raimund I., Kaech, Susan, Wendel, Hans-Guido, Yates, John R., Han, Weiping, Sherwin, Robert S., Nie, Yongzhan, Yang, Xiaoyong
Format:	Artikel
Sprache:	eng
Schlagworte:	13/105 13/106 38/70 38/89 42/109 42/44 631/45/221 631/67/2327 64/60 82/51 82/58 82/83 Acetylation Acetylglucosamine - metabolism Acetyltransferase Animals Antigens, Neoplasm - metabolism Apoptosis Cancer Carrier Proteins - metabolism Cell Biology Cell Line, Tumor Datasets as Topic Development and progression Dextrose Disease Progression Enzymes Female Gene Expression Profiling Glucose Glucose metabolism Glycolysis Growth HEK293 Cells Histone Acetyltransferases - metabolism Human Genetics Humans Hyaluronoglucosaminidase - metabolism Hydrolase Internal Medicine Kinases Lysine Male Medicine Medicine & Public Health Membrane Proteins - metabolism Metabolism Mice N-Acetylglucosamine N-Acetylglucosaminyltransferases - metabolism Neoplasm Grading Neoplasm Staging Neoplasms - metabolism Neoplasms - pathology O-GlcNAcylation Oncology Protein Processing, Post-Translational Pyruvate kinase Pyruvic acid Thyroid Hormone-Binding Proteins Thyroid Hormones - metabolism Tissue Array Analysis Up-Regulation Xenograft Model Antitumor Assays
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