Both L- and D-Lactate Contribute to Metabolic Acidosis in Diarrheic Calves
Diarrhea in neonates is often complicated by metabolic acidosis. We used blood gas analysis and HPLC to determine whether bacterial fermentation might contribute to acidosis in diarrheic calves. Diarrheic calves (n = 21) had significantly lower pH, PCO2, HCO3− and a higher anion gap than healthy cal...
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| Veröffentlicht in: | The Journal of nutrition 2001-08, Vol.131 (8), p.2128-2131 |
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| creator | Omole, Olutosin O. Nappert, Germain Naylor, Jonathan M. Zello, Gordon A. |
| description | Diarrhea in neonates is often complicated by metabolic acidosis. We used blood gas analysis and HPLC to determine whether bacterial fermentation might contribute to acidosis in diarrheic calves. Diarrheic calves (n = 21) had significantly lower pH, PCO2, HCO3− and a higher anion gap than healthy calves (n = 21). Serum concentrations (mean ± SD, mmol/L) of DL-,L- and D-lactate were also significantly higher in diarrheic (8.9 ± 5.1, 4.1 ± 3.4 and 5.2 ± 5.7) than in healthy calves (1.7 ± 1.2, 2.0 ± 1.1 and too low to quantify). D- and L-lactate accounted for 64% anion gap increase in diarrheic calves. Fecal D- and L-lactate concentrations were also significantly higher in diarrheic calves (9.4 ± 3.0 and 11.9 ± 2.7 mmol/L) than healthy calves (1.1 ± 0.1 and 1.6 ± 0.1 mmol/L). The elevated concentrations of serum and fecal D-lactate suggest gut bacterial fermentation contributes to the development of acidosis in diarrhea. |
| doi_str_mv | 10.1093/jn/131.8.2128 |
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We used blood gas analysis and HPLC to determine whether bacterial fermentation might contribute to acidosis in diarrheic calves. Diarrheic calves (n = 21) had significantly lower pH, PCO2, HCO3− and a higher anion gap than healthy calves (n = 21). Serum concentrations (mean ± SD, mmol/L) of DL-,L- and D-lactate were also significantly higher in diarrheic (8.9 ± 5.1, 4.1 ± 3.4 and 5.2 ± 5.7) than in healthy calves (1.7 ± 1.2, 2.0 ± 1.1 and too low to quantify). D- and L-lactate accounted for 64% anion gap increase in diarrheic calves. Fecal D- and L-lactate concentrations were also significantly higher in diarrheic calves (9.4 ± 3.0 and 11.9 ± 2.7 mmol/L) than healthy calves (1.1 ± 0.1 and 1.6 ± 0.1 mmol/L). The elevated concentrations of serum and fecal D-lactate suggest gut bacterial fermentation contributes to the development of acidosis in diarrhea.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/131.8.2128</identifier><identifier>PMID: 11481406</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Acid-Base Equilibrium ; acidosis ; Acidosis, Lactic - blood ; Acidosis, Lactic - etiology ; Acidosis, Lactic - veterinary ; Animals ; Animals, Suckling ; Bacteria ; Bacteria - metabolism ; Biological and medical sciences ; calves ; Carbon Dioxide - blood ; Cattle ; Cattle Diseases - blood ; Cattle Diseases - etiology ; Chromatography ; Chromatography, High Pressure Liquid ; D-lactic acid ; Diarrhea ; Diarrhea - blood ; Diarrhea - complications ; Diarrhea - microbiology ; Diarrhea - veterinary ; Feces - chemistry ; Fermentation ; Gastroenterology. Liver. Pancreas. Abdomen ; high performance liquid chromatography ; Intestinal Mucosa - metabolism ; Intestines - microbiology ; Lactic Acid - analysis ; Lactic Acid - blood ; Medical sciences ; Other diseases. Semiology ; Oxygen - blood ; Stomach. Duodenum. Small intestine. Colon. Rectum. 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We used blood gas analysis and HPLC to determine whether bacterial fermentation might contribute to acidosis in diarrheic calves. Diarrheic calves (n = 21) had significantly lower pH, PCO2, HCO3− and a higher anion gap than healthy calves (n = 21). Serum concentrations (mean ± SD, mmol/L) of DL-,L- and D-lactate were also significantly higher in diarrheic (8.9 ± 5.1, 4.1 ± 3.4 and 5.2 ± 5.7) than in healthy calves (1.7 ± 1.2, 2.0 ± 1.1 and too low to quantify). D- and L-lactate accounted for 64% anion gap increase in diarrheic calves. Fecal D- and L-lactate concentrations were also significantly higher in diarrheic calves (9.4 ± 3.0 and 11.9 ± 2.7 mmol/L) than healthy calves (1.1 ± 0.1 and 1.6 ± 0.1 mmol/L). The elevated concentrations of serum and fecal D-lactate suggest gut bacterial fermentation contributes to the development of acidosis in diarrhea.</description><subject>Acid-Base Equilibrium</subject><subject>acidosis</subject><subject>Acidosis, Lactic - blood</subject><subject>Acidosis, Lactic - etiology</subject><subject>Acidosis, Lactic - veterinary</subject><subject>Animals</subject><subject>Animals, Suckling</subject><subject>Bacteria</subject><subject>Bacteria - metabolism</subject><subject>Biological and medical sciences</subject><subject>calves</subject><subject>Carbon Dioxide - blood</subject><subject>Cattle</subject><subject>Cattle Diseases - blood</subject><subject>Cattle Diseases - etiology</subject><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid</subject><subject>D-lactic acid</subject><subject>Diarrhea</subject><subject>Diarrhea - blood</subject><subject>Diarrhea - complications</subject><subject>Diarrhea - microbiology</subject><subject>Diarrhea - veterinary</subject><subject>Feces - chemistry</subject><subject>Fermentation</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>high performance liquid chromatography</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestines - microbiology</subject><subject>Lactic Acid - analysis</subject><subject>Lactic Acid - blood</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Oxygen - blood</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10cFvFCEUBnBiNHatHr2aiYneZssbhoG5mLRbrTbbeNEzYeCNy2YWKjCb-N_LZjfWmniCwC8vH3yEvAa6BNqzi62_AAZLuWygkU_IAngLdQeUPiULSpumZtB1Z-RFSltKKbS9fE7OAFoJLe0W5PYq5E21rivtbXVdr7XJOmO1Cj5HN8xlm0N1h1kPYXKmujTOhuRS5Xx17XSMGyynKz3tMb0kz0Y9JXx1Ws_J908fv60-1-uvN19Wl-vacNnkGoRF2-gOkTE6jsxwC_0wChiZsNxKbY3GRg9UUGZ6jqPoUdi259x21jLGzsmH49z7edihNVii6kndR7fT8ZcK2qnHN95t1I-wVwKoaDtaBrw_DYjh54wpq51LBqdJewxzOjjecXmAb_-B2zBHXx6noBctF1KIguojMjGkFHH8kwSoOlSktl6VipRUh4qKf_N3_Ad96qSAdyegk9HTGLU3Lj24FkA2FIoTR4fls_cOo0rGoTdoXUSTlQ3uPxF-A6Ymq9Q</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>Omole, Olutosin O.</creator><creator>Nappert, Germain</creator><creator>Naylor, Jonathan M.</creator><creator>Zello, Gordon A.</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><general>American Institute of Nutrition</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20010801</creationdate><title>Both L- and D-Lactate Contribute to Metabolic Acidosis in Diarrheic Calves</title><author>Omole, Olutosin O. ; Nappert, Germain ; Naylor, Jonathan M. ; Zello, Gordon A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c582t-17ded2a6ee330ff3c5d19bf71f37d5d8adcae2ab0703c95ef79e7d4955d6dd333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Acid-Base Equilibrium</topic><topic>acidosis</topic><topic>Acidosis, Lactic - blood</topic><topic>Acidosis, Lactic - etiology</topic><topic>Acidosis, Lactic - veterinary</topic><topic>Animals</topic><topic>Animals, Suckling</topic><topic>Bacteria</topic><topic>Bacteria - metabolism</topic><topic>Biological and medical sciences</topic><topic>calves</topic><topic>Carbon Dioxide - blood</topic><topic>Cattle</topic><topic>Cattle Diseases - blood</topic><topic>Cattle Diseases - etiology</topic><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid</topic><topic>D-lactic acid</topic><topic>Diarrhea</topic><topic>Diarrhea - blood</topic><topic>Diarrhea - complications</topic><topic>Diarrhea - microbiology</topic><topic>Diarrhea - veterinary</topic><topic>Feces - chemistry</topic><topic>Fermentation</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>high performance liquid chromatography</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestines - microbiology</topic><topic>Lactic Acid - analysis</topic><topic>Lactic Acid - blood</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Oxygen - blood</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Omole, Olutosin O.</creatorcontrib><creatorcontrib>Nappert, Germain</creatorcontrib><creatorcontrib>Naylor, Jonathan M.</creatorcontrib><creatorcontrib>Zello, Gordon A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Omole, Olutosin O.</au><au>Nappert, Germain</au><au>Naylor, Jonathan M.</au><au>Zello, Gordon A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Both L- and D-Lactate Contribute to Metabolic Acidosis in Diarrheic Calves</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>131</volume><issue>8</issue><spage>2128</spage><epage>2131</epage><pages>2128-2131</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>Diarrhea in neonates is often complicated by metabolic acidosis. We used blood gas analysis and HPLC to determine whether bacterial fermentation might contribute to acidosis in diarrheic calves. Diarrheic calves (n = 21) had significantly lower pH, PCO2, HCO3− and a higher anion gap than healthy calves (n = 21). Serum concentrations (mean ± SD, mmol/L) of DL-,L- and D-lactate were also significantly higher in diarrheic (8.9 ± 5.1, 4.1 ± 3.4 and 5.2 ± 5.7) than in healthy calves (1.7 ± 1.2, 2.0 ± 1.1 and too low to quantify). D- and L-lactate accounted for 64% anion gap increase in diarrheic calves. Fecal D- and L-lactate concentrations were also significantly higher in diarrheic calves (9.4 ± 3.0 and 11.9 ± 2.7 mmol/L) than healthy calves (1.1 ± 0.1 and 1.6 ± 0.1 mmol/L). The elevated concentrations of serum and fecal D-lactate suggest gut bacterial fermentation contributes to the development of acidosis in diarrhea.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>11481406</pmid><doi>10.1093/jn/131.8.2128</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acid-Base Equilibrium acidosis Acidosis, Lactic - blood Acidosis, Lactic - etiology Acidosis, Lactic - veterinary Animals Animals, Suckling Bacteria Bacteria - metabolism Biological and medical sciences calves Carbon Dioxide - blood Cattle Cattle Diseases - blood Cattle Diseases - etiology Chromatography Chromatography, High Pressure Liquid D-lactic acid Diarrhea Diarrhea - blood Diarrhea - complications Diarrhea - microbiology Diarrhea - veterinary Feces - chemistry Fermentation Gastroenterology. Liver. Pancreas. Abdomen high performance liquid chromatography Intestinal Mucosa - metabolism Intestines - microbiology Lactic Acid - analysis Lactic Acid - blood Medical sciences Other diseases. Semiology Oxygen - blood Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | Both L- and D-Lactate Contribute to Metabolic Acidosis in Diarrheic Calves |
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