Rapid replacement of human respiratory syncytial virus A with the ON1 genotype having 72 nucleotide duplication in G gene
•We investigated the prevalence of HRSV during 2008–2013.•Novel HRSV-A ON1 genotype was emerged in August 2011.•After 1year of emergence in 2012–2013, 94.6% was replaced with novel ON1 genotype.•Evolutionary dynamics also drastically increased in 2011.•The result of epitope prediction shows the poss...
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| Veröffentlicht in: | Infection, genetics and evolution genetics and evolution, 2014-08, Vol.26, p.103-112 |
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| creator | Kim, You-Jin Kim, Dae-Won Lee, Wan-Ji Yun, Mi-Ran Lee, Ho Yeon Lee, Han Saem Jung, Hee-Dong Kim, Kisoon |
| description | •We investigated the prevalence of HRSV during 2008–2013.•Novel HRSV-A ON1 genotype was emerged in August 2011.•After 1year of emergence in 2012–2013, 94.6% was replaced with novel ON1 genotype.•Evolutionary dynamics also drastically increased in 2011.•The result of epitope prediction shows the possibilities of antigenic variation.
Human respiratory syncytial virus (HRSV) is the main cause of severe respiratory illness in young children and elderly people. We investigated the genetic characteristics of the circulating HRSV subgroup A (HRSV-A) to determine the distribution of genotype ON1, which has a 72-nucleotide duplication in attachment G gene. We obtained 456 HRSV-A positive samples between October 2008 and February 2013, which were subjected to sequence analysis. The first ON1 genotype was discovered in August 2011 and 273 samples were identified as ON1 up to February 2013. The prevalence of the ON1 genotype increased rapidly from 17.4% in 2011–2012 to 94.6% in 2012–2013. The mean evolutionary rate of G protein was calculated as 3.275×10−3 nucleotide substitution/site/year and several positively selected sites for amino acid substitutions were located in the predicted epitope region. This basic and important information may facilitate a better understanding of HRSV epidemiology and evolution. |
| doi_str_mv | 10.1016/j.meegid.2014.05.007 |
| format | Article |
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Human respiratory syncytial virus (HRSV) is the main cause of severe respiratory illness in young children and elderly people. We investigated the genetic characteristics of the circulating HRSV subgroup A (HRSV-A) to determine the distribution of genotype ON1, which has a 72-nucleotide duplication in attachment G gene. We obtained 456 HRSV-A positive samples between October 2008 and February 2013, which were subjected to sequence analysis. The first ON1 genotype was discovered in August 2011 and 273 samples were identified as ON1 up to February 2013. The prevalence of the ON1 genotype increased rapidly from 17.4% in 2011–2012 to 94.6% in 2012–2013. The mean evolutionary rate of G protein was calculated as 3.275×10−3 nucleotide substitution/site/year and several positively selected sites for amino acid substitutions were located in the predicted epitope region. This basic and important information may facilitate a better understanding of HRSV epidemiology and evolution.</description><identifier>ISSN: 1567-1348</identifier><identifier>EISSN: 1567-7257</identifier><identifier>DOI: 10.1016/j.meegid.2014.05.007</identifier><identifier>PMID: 24820343</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Amino Acid Sequence ; amino acid substitution ; Attachment G gene ; Child ; Child, Preschool ; Diversity ; Duplication ; epidemiology ; epitopes ; Epitopes - chemistry ; Epitopes - immunology ; Evolution ; Evolution, Molecular ; Female ; genes ; Genotype ; History, 21st Century ; Human orthopneumovirus ; Human respiratory syncytial virus (HRSV) ; Humans ; Infant ; Male ; Molecular Sequence Data ; Mutation ; Phylogeny ; Prevalence ; Republic of Korea ; Respiratory Syncytial Virus Infections - epidemiology ; Respiratory Syncytial Virus Infections - history ; Respiratory Syncytial Virus Infections - immunology ; Respiratory Syncytial Virus Infections - virology ; Respiratory Syncytial Virus, Human - classification ; Respiratory Syncytial Virus, Human - genetics ; Respiratory Syncytial Virus, Human - immunology ; Respiratory Syncytial Virus, Human - isolation & purification ; Seasons ; Selection, Genetic ; Sequence Alignment ; sequence analysis ; Viral Fusion Proteins - genetics</subject><ispartof>Infection, genetics and evolution, 2014-08, Vol.26, p.103-112</ispartof><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved. 2014 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-c413edc5b2d9852e7e2b1aa9022fc80dfc7d03ee8b3b0d677123a431298b4ca53</citedby><cites>FETCH-LOGICAL-c496t-c413edc5b2d9852e7e2b1aa9022fc80dfc7d03ee8b3b0d677123a431298b4ca53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S156713481400166X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24820343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, You-Jin</creatorcontrib><creatorcontrib>Kim, Dae-Won</creatorcontrib><creatorcontrib>Lee, Wan-Ji</creatorcontrib><creatorcontrib>Yun, Mi-Ran</creatorcontrib><creatorcontrib>Lee, Ho Yeon</creatorcontrib><creatorcontrib>Lee, Han Saem</creatorcontrib><creatorcontrib>Jung, Hee-Dong</creatorcontrib><creatorcontrib>Kim, Kisoon</creatorcontrib><title>Rapid replacement of human respiratory syncytial virus A with the ON1 genotype having 72 nucleotide duplication in G gene</title><title>Infection, genetics and evolution</title><addtitle>Infect Genet Evol</addtitle><description>•We investigated the prevalence of HRSV during 2008–2013.•Novel HRSV-A ON1 genotype was emerged in August 2011.•After 1year of emergence in 2012–2013, 94.6% was replaced with novel ON1 genotype.•Evolutionary dynamics also drastically increased in 2011.•The result of epitope prediction shows the possibilities of antigenic variation.
Human respiratory syncytial virus (HRSV) is the main cause of severe respiratory illness in young children and elderly people. We investigated the genetic characteristics of the circulating HRSV subgroup A (HRSV-A) to determine the distribution of genotype ON1, which has a 72-nucleotide duplication in attachment G gene. We obtained 456 HRSV-A positive samples between October 2008 and February 2013, which were subjected to sequence analysis. The first ON1 genotype was discovered in August 2011 and 273 samples were identified as ON1 up to February 2013. The prevalence of the ON1 genotype increased rapidly from 17.4% in 2011–2012 to 94.6% in 2012–2013. The mean evolutionary rate of G protein was calculated as 3.275×10−3 nucleotide substitution/site/year and several positively selected sites for amino acid substitutions were located in the predicted epitope region. This basic and important information may facilitate a better understanding of HRSV epidemiology and evolution.</description><subject>Amino Acid Sequence</subject><subject>amino acid substitution</subject><subject>Attachment G gene</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diversity</subject><subject>Duplication</subject><subject>epidemiology</subject><subject>epitopes</subject><subject>Epitopes - chemistry</subject><subject>Epitopes - immunology</subject><subject>Evolution</subject><subject>Evolution, Molecular</subject><subject>Female</subject><subject>genes</subject><subject>Genotype</subject><subject>History, 21st Century</subject><subject>Human orthopneumovirus</subject><subject>Human respiratory syncytial virus (HRSV)</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Phylogeny</subject><subject>Prevalence</subject><subject>Republic of Korea</subject><subject>Respiratory Syncytial Virus Infections - epidemiology</subject><subject>Respiratory Syncytial Virus Infections - history</subject><subject>Respiratory Syncytial Virus Infections - immunology</subject><subject>Respiratory Syncytial Virus Infections - virology</subject><subject>Respiratory Syncytial Virus, Human - classification</subject><subject>Respiratory Syncytial Virus, Human - genetics</subject><subject>Respiratory Syncytial Virus, Human - immunology</subject><subject>Respiratory Syncytial Virus, Human - isolation & purification</subject><subject>Seasons</subject><subject>Selection, Genetic</subject><subject>Sequence Alignment</subject><subject>sequence analysis</subject><subject>Viral Fusion Proteins - genetics</subject><issn>1567-1348</issn><issn>1567-7257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVGP1CAUhRujcdfVf2AMj75MvUBbOi8mm42uJhs3MfpMKNxOmbRQgc6m_14mM676oi9A4NxzOfcritcUSgq0ebcvJ8SdNSUDWpVQlwDiSXFJ60ZsBKvF0_OZ8qq9KF7EuAegAlj7vLhgVcuAV_yyWL-q2RoScB6VxgldIr4nwzIply_jbINKPqwkrk6vyaqRHGxYIrkmDzYNJA1I7r9QskPn0zojGdTBuh0RjLhFj-iTNUjMMo9Wq2S9I9aR26McXxbPejVGfHXer4rvHz98u_m0ubu__XxzfbfR1bZJeaUcja47ZrZtzVAg66hSW2Cs1y2YXgsDHLHteAemEYIyripO2bbtKq1qflW8P_nOSzdlpxwxqFHOwU4qrNIrK_9-cXaQO3-QgkJDeZMN3p4Ngv-xYExyslHjOCqHfomSQR5sQ0UF_5XSus7stpwepdVJqoOPMWD_-CMK8ghY7uUJsDwCllDLDDiXvfkzzWPRL6K_42Ke6cFikFFbdBqNDaiTNN7-u8NPlfS6vQ</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Kim, You-Jin</creator><creator>Kim, Dae-Won</creator><creator>Lee, Wan-Ji</creator><creator>Yun, Mi-Ran</creator><creator>Lee, Ho Yeon</creator><creator>Lee, Han Saem</creator><creator>Jung, Hee-Dong</creator><creator>Kim, Kisoon</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20140801</creationdate><title>Rapid replacement of human respiratory syncytial virus A with the ON1 genotype having 72 nucleotide duplication in G gene</title><author>Kim, You-Jin ; Kim, Dae-Won ; Lee, Wan-Ji ; Yun, Mi-Ran ; Lee, Ho Yeon ; Lee, Han Saem ; Jung, Hee-Dong ; Kim, Kisoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-c413edc5b2d9852e7e2b1aa9022fc80dfc7d03ee8b3b0d677123a431298b4ca53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Amino Acid Sequence</topic><topic>amino acid substitution</topic><topic>Attachment G gene</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diversity</topic><topic>Duplication</topic><topic>epidemiology</topic><topic>epitopes</topic><topic>Epitopes - chemistry</topic><topic>Epitopes - immunology</topic><topic>Evolution</topic><topic>Evolution, Molecular</topic><topic>Female</topic><topic>genes</topic><topic>Genotype</topic><topic>History, 21st Century</topic><topic>Human orthopneumovirus</topic><topic>Human respiratory syncytial virus (HRSV)</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Phylogeny</topic><topic>Prevalence</topic><topic>Republic of Korea</topic><topic>Respiratory Syncytial Virus Infections - epidemiology</topic><topic>Respiratory Syncytial Virus Infections - history</topic><topic>Respiratory Syncytial Virus Infections - immunology</topic><topic>Respiratory Syncytial Virus Infections - virology</topic><topic>Respiratory Syncytial Virus, Human - classification</topic><topic>Respiratory Syncytial Virus, Human - genetics</topic><topic>Respiratory Syncytial Virus, Human - immunology</topic><topic>Respiratory Syncytial Virus, Human - isolation & purification</topic><topic>Seasons</topic><topic>Selection, Genetic</topic><topic>Sequence Alignment</topic><topic>sequence analysis</topic><topic>Viral Fusion Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, You-Jin</creatorcontrib><creatorcontrib>Kim, Dae-Won</creatorcontrib><creatorcontrib>Lee, Wan-Ji</creatorcontrib><creatorcontrib>Yun, Mi-Ran</creatorcontrib><creatorcontrib>Lee, Ho Yeon</creatorcontrib><creatorcontrib>Lee, Han Saem</creatorcontrib><creatorcontrib>Jung, Hee-Dong</creatorcontrib><creatorcontrib>Kim, Kisoon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Infection, genetics and evolution</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, You-Jin</au><au>Kim, Dae-Won</au><au>Lee, Wan-Ji</au><au>Yun, Mi-Ran</au><au>Lee, Ho Yeon</au><au>Lee, Han Saem</au><au>Jung, Hee-Dong</au><au>Kim, Kisoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid replacement of human respiratory syncytial virus A with the ON1 genotype having 72 nucleotide duplication in G gene</atitle><jtitle>Infection, genetics and evolution</jtitle><addtitle>Infect Genet Evol</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>26</volume><spage>103</spage><epage>112</epage><pages>103-112</pages><issn>1567-1348</issn><eissn>1567-7257</eissn><abstract>•We investigated the prevalence of HRSV during 2008–2013.•Novel HRSV-A ON1 genotype was emerged in August 2011.•After 1year of emergence in 2012–2013, 94.6% was replaced with novel ON1 genotype.•Evolutionary dynamics also drastically increased in 2011.•The result of epitope prediction shows the possibilities of antigenic variation.
Human respiratory syncytial virus (HRSV) is the main cause of severe respiratory illness in young children and elderly people. We investigated the genetic characteristics of the circulating HRSV subgroup A (HRSV-A) to determine the distribution of genotype ON1, which has a 72-nucleotide duplication in attachment G gene. We obtained 456 HRSV-A positive samples between October 2008 and February 2013, which were subjected to sequence analysis. The first ON1 genotype was discovered in August 2011 and 273 samples were identified as ON1 up to February 2013. The prevalence of the ON1 genotype increased rapidly from 17.4% in 2011–2012 to 94.6% in 2012–2013. The mean evolutionary rate of G protein was calculated as 3.275×10−3 nucleotide substitution/site/year and several positively selected sites for amino acid substitutions were located in the predicted epitope region. This basic and important information may facilitate a better understanding of HRSV epidemiology and evolution.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24820343</pmid><doi>10.1016/j.meegid.2014.05.007</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence amino acid substitution Attachment G gene Child Child, Preschool Diversity Duplication epidemiology epitopes Epitopes - chemistry Epitopes - immunology Evolution Evolution, Molecular Female genes Genotype History, 21st Century Human orthopneumovirus Human respiratory syncytial virus (HRSV) Humans Infant Male Molecular Sequence Data Mutation Phylogeny Prevalence Republic of Korea Respiratory Syncytial Virus Infections - epidemiology Respiratory Syncytial Virus Infections - history Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - virology Respiratory Syncytial Virus, Human - classification Respiratory Syncytial Virus, Human - genetics Respiratory Syncytial Virus, Human - immunology Respiratory Syncytial Virus, Human - isolation & purification Seasons Selection, Genetic Sequence Alignment sequence analysis Viral Fusion Proteins - genetics |
| title | Rapid replacement of human respiratory syncytial virus A with the ON1 genotype having 72 nucleotide duplication in G gene |
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