Gut, oral and skin microbiome of Indian patrilineal families reveal perceptible association with age
The human microbiome plays a key role in maintaining host homeostasis and is influenced by age, geography, diet, and other factors. Traditionally, India has an established convention of extended family arrangements wherein three or more generations, bound by genetic relatedness, stay in the same hou...
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| Veröffentlicht in: | Scientific reports 2020-03, Vol.10 (1), p.5685-5685, Article 5685 |
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| creator | Chaudhari, Diptaraj S. Dhotre, Dhiraj P. Agarwal, Dhiraj M. Gaike, Akshay H. Bhalerao, Devika Jadhav, Parmeshwar Mongad, Dattatray Lubree, Himangi Sinkar, Vilas P. Patil, Ulhas K. Salvi, Sundeep Bavdekar, Ashish Juvekar, Sanjay K. Shouche, Yogesh S. |
| description | The human microbiome plays a key role in maintaining host homeostasis and is influenced by age, geography, diet, and other factors. Traditionally, India has an established convention of extended family arrangements wherein three or more generations, bound by genetic relatedness, stay in the same household. In the present study, we have utilized this unique family arrangement to understand the association of age with the microbiome. We characterized stool, oral and skin microbiome of 54 healthy individuals from six joint families by 16S rRNA gene-based metagenomics. In total, 69 (1.03%), 293 (2.68%) and 190 (8.66%) differentially abundant OTUs were detected across three generations in the gut, skin and oral microbiome, respectively. Age-associated changes in the gut and oral microbiome of patrilineal families showed positive correlations in the abundance of phyla Proteobacteria and Fusobacteria, respectively. Genera
Treponema
and
Fusobacterium
showed a positive correlation with age while
Granulicatella
and
Streptococcus
showed a negative correlation with age in the oral microbiome. Members of genus
Prevotella
illustrated high abundance and prevalence as a core OTUs in the gut and oral microbiome. In conclusion, this study highlights that precise and perceptible association of age with microbiome can be drawn when other causal factors are kept constant. |
| doi_str_mv | 10.1038/s41598-020-62195-5 |
| format | Article |
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Treponema
and
Fusobacterium
showed a positive correlation with age while
Granulicatella
and
Streptococcus
showed a negative correlation with age in the oral microbiome. Members of genus
Prevotella
illustrated high abundance and prevalence as a core OTUs in the gut and oral microbiome. In conclusion, this study highlights that precise and perceptible association of age with microbiome can be drawn when other causal factors are kept constant.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-62195-5</identifier><identifier>PMID: 32231240</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45/22 ; 45/23 ; 45/77 ; 631/158/2452 ; 631/158/855 ; Abundance ; Adolescent ; Adult ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Bacteria - genetics ; Child ; Child, Preschool ; Family ; Feces - microbiology ; Female ; Gastrointestinal Microbiome - genetics ; Geography ; Homeostasis ; Humanities and Social Sciences ; Humans ; India - epidemiology ; Male ; Metagenome - genetics ; Metagenomics ; Metagenomics - methods ; Microbiomes ; Microbiota - genetics ; Middle Aged ; Mouth - microbiology ; multidisciplinary ; RNA, Ribosomal, 16S - genetics ; rRNA 16S ; Science ; Science (multidisciplinary) ; Skin ; Skin - microbiology</subject><ispartof>Scientific reports, 2020-03, Vol.10 (1), p.5685-5685, Article 5685</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-87a3ec813312836b68785c460540995e0fed47cd0eb58118de882795c0135203</citedby><cites>FETCH-LOGICAL-c522t-87a3ec813312836b68785c460540995e0fed47cd0eb58118de882795c0135203</cites><orcidid>0000-0002-7209-6924 ; 0000-0002-5055-5931</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105498/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105498/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32231240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chaudhari, Diptaraj S.</creatorcontrib><creatorcontrib>Dhotre, Dhiraj P.</creatorcontrib><creatorcontrib>Agarwal, Dhiraj M.</creatorcontrib><creatorcontrib>Gaike, Akshay H.</creatorcontrib><creatorcontrib>Bhalerao, Devika</creatorcontrib><creatorcontrib>Jadhav, Parmeshwar</creatorcontrib><creatorcontrib>Mongad, Dattatray</creatorcontrib><creatorcontrib>Lubree, Himangi</creatorcontrib><creatorcontrib>Sinkar, Vilas P.</creatorcontrib><creatorcontrib>Patil, Ulhas K.</creatorcontrib><creatorcontrib>Salvi, Sundeep</creatorcontrib><creatorcontrib>Bavdekar, Ashish</creatorcontrib><creatorcontrib>Juvekar, Sanjay K.</creatorcontrib><creatorcontrib>Shouche, Yogesh S.</creatorcontrib><title>Gut, oral and skin microbiome of Indian patrilineal families reveal perceptible association with age</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The human microbiome plays a key role in maintaining host homeostasis and is influenced by age, geography, diet, and other factors. Traditionally, India has an established convention of extended family arrangements wherein three or more generations, bound by genetic relatedness, stay in the same household. In the present study, we have utilized this unique family arrangement to understand the association of age with the microbiome. We characterized stool, oral and skin microbiome of 54 healthy individuals from six joint families by 16S rRNA gene-based metagenomics. In total, 69 (1.03%), 293 (2.68%) and 190 (8.66%) differentially abundant OTUs were detected across three generations in the gut, skin and oral microbiome, respectively. Age-associated changes in the gut and oral microbiome of patrilineal families showed positive correlations in the abundance of phyla Proteobacteria and Fusobacteria, respectively. Genera
Treponema
and
Fusobacterium
showed a positive correlation with age while
Granulicatella
and
Streptococcus
showed a negative correlation with age in the oral microbiome. Members of genus
Prevotella
illustrated high abundance and prevalence as a core OTUs in the gut and oral microbiome. In conclusion, this study highlights that precise and perceptible association of age with microbiome can be drawn when other causal factors are kept constant.</description><subject>45/22</subject><subject>45/23</subject><subject>45/77</subject><subject>631/158/2452</subject><subject>631/158/855</subject><subject>Abundance</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bacteria - genetics</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Family</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Gastrointestinal Microbiome - genetics</subject><subject>Geography</subject><subject>Homeostasis</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Male</subject><subject>Metagenome - genetics</subject><subject>Metagenomics</subject><subject>Metagenomics - methods</subject><subject>Microbiomes</subject><subject>Microbiota - genetics</subject><subject>Middle Aged</subject><subject>Mouth - microbiology</subject><subject>multidisciplinary</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>rRNA 16S</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Skin</subject><subject>Skin - microbiology</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1O3TAQha2KqiDKC3RRWWLDomntcZzYGySEWoqE1A17y3EmF9PEDnYC6tvXt5dS6AJv_DPfnJnxIeQDZ585E-pLrrnUqmLAqga4lpV8Qw6A1bICAbD37LxPjnK-ZWVJ0DXX78h-eRUcanZA-ot1-URjsiO1oaf5pw908i7FzscJaRzoZei9DXS2S_KjD1jIwU7liJkmvN_eZ0wO58V3I1Kbc3TeLj4G-uCXG2o3-J68HeyY8ehxPyTX375en3-vrn5cXJ6fXVVOAiyVaq1Ap7govSnRdI1qlXR1w2TNtJbIBuzr1vUMO6k4Vz0qBa2WjnEhgYlDcrqTndduwt5hWMpcZk5-sumXidabl5Hgb8wm3puWlxJaFYGTR4EU71bMi5l8djiONmBcswGhJLSy4bygx_-ht3FNoUy3pWoApnRbKNhR5UNzTjg8NcOZ2dpodjaaYqP5Y6ORJenj8zGeUv6aVgCxA3IJhQ2mf7Vfkf0NGFWn1w</recordid><startdate>20200330</startdate><enddate>20200330</enddate><creator>Chaudhari, Diptaraj S.</creator><creator>Dhotre, Dhiraj P.</creator><creator>Agarwal, Dhiraj M.</creator><creator>Gaike, Akshay H.</creator><creator>Bhalerao, Devika</creator><creator>Jadhav, Parmeshwar</creator><creator>Mongad, Dattatray</creator><creator>Lubree, Himangi</creator><creator>Sinkar, Vilas P.</creator><creator>Patil, Ulhas K.</creator><creator>Salvi, Sundeep</creator><creator>Bavdekar, Ashish</creator><creator>Juvekar, Sanjay K.</creator><creator>Shouche, Yogesh S.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7209-6924</orcidid><orcidid>https://orcid.org/0000-0002-5055-5931</orcidid></search><sort><creationdate>20200330</creationdate><title>Gut, oral and skin microbiome of Indian patrilineal families reveal perceptible association with age</title><author>Chaudhari, Diptaraj S. ; Dhotre, Dhiraj P. ; Agarwal, Dhiraj M. ; Gaike, Akshay H. ; Bhalerao, Devika ; Jadhav, Parmeshwar ; Mongad, Dattatray ; Lubree, Himangi ; Sinkar, Vilas P. ; Patil, Ulhas K. ; Salvi, Sundeep ; Bavdekar, Ashish ; Juvekar, Sanjay K. ; Shouche, Yogesh S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-87a3ec813312836b68785c460540995e0fed47cd0eb58118de882795c0135203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>45/22</topic><topic>45/23</topic><topic>45/77</topic><topic>631/158/2452</topic><topic>631/158/855</topic><topic>Abundance</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bacteria - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chaudhari, Diptaraj S.</au><au>Dhotre, Dhiraj P.</au><au>Agarwal, Dhiraj M.</au><au>Gaike, Akshay H.</au><au>Bhalerao, Devika</au><au>Jadhav, Parmeshwar</au><au>Mongad, Dattatray</au><au>Lubree, Himangi</au><au>Sinkar, Vilas P.</au><au>Patil, Ulhas K.</au><au>Salvi, Sundeep</au><au>Bavdekar, Ashish</au><au>Juvekar, Sanjay K.</au><au>Shouche, Yogesh S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut, oral and skin microbiome of Indian patrilineal families reveal perceptible association with age</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-03-30</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>5685</spage><epage>5685</epage><pages>5685-5685</pages><artnum>5685</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The human microbiome plays a key role in maintaining host homeostasis and is influenced by age, geography, diet, and other factors. Traditionally, India has an established convention of extended family arrangements wherein three or more generations, bound by genetic relatedness, stay in the same household. In the present study, we have utilized this unique family arrangement to understand the association of age with the microbiome. We characterized stool, oral and skin microbiome of 54 healthy individuals from six joint families by 16S rRNA gene-based metagenomics. In total, 69 (1.03%), 293 (2.68%) and 190 (8.66%) differentially abundant OTUs were detected across three generations in the gut, skin and oral microbiome, respectively. Age-associated changes in the gut and oral microbiome of patrilineal families showed positive correlations in the abundance of phyla Proteobacteria and Fusobacteria, respectively. Genera
Treponema
and
Fusobacterium
showed a positive correlation with age while
Granulicatella
and
Streptococcus
showed a negative correlation with age in the oral microbiome. Members of genus
Prevotella
illustrated high abundance and prevalence as a core OTUs in the gut and oral microbiome. In conclusion, this study highlights that precise and perceptible association of age with microbiome can be drawn when other causal factors are kept constant.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32231240</pmid><doi>10.1038/s41598-020-62195-5</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7209-6924</orcidid><orcidid>https://orcid.org/0000-0002-5055-5931</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 45/22 45/23 45/77 631/158/2452 631/158/855 Abundance Adolescent Adult Age Age Factors Aged Aged, 80 and over Bacteria - genetics Child Child, Preschool Family Feces - microbiology Female Gastrointestinal Microbiome - genetics Geography Homeostasis Humanities and Social Sciences Humans India - epidemiology Male Metagenome - genetics Metagenomics Metagenomics - methods Microbiomes Microbiota - genetics Middle Aged Mouth - microbiology multidisciplinary RNA, Ribosomal, 16S - genetics rRNA 16S Science Science (multidisciplinary) Skin Skin - microbiology |
| title | Gut, oral and skin microbiome of Indian patrilineal families reveal perceptible association with age |
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