Sex differences in pediatric traumatic brain injury
The response of the developing brain to traumatic injury is different from the response of the mature, adult brain. There are critical developmental trajectories in the young brain, whereby injury can lead to long term functional abnormalities. Emerging preclinical and clinical literature supports t...
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| Veröffentlicht in: | Experimental neurology 2019-07, Vol.317, p.168-179 |
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| container_title | Experimental neurology |
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| creator | Arambula, Sheryl E. Reinl, Erin L. El Demerdash, Nagat McCarthy, Margaret M. Robertson, Courtney L. |
| description | The response of the developing brain to traumatic injury is different from the response of the mature, adult brain. There are critical developmental trajectories in the young brain, whereby injury can lead to long term functional abnormalities. Emerging preclinical and clinical literature supports the presence of significant sex differences in both the response to and the recovery from pediatric traumatic brain injury (TBI). These sex differences are seen at all pediatric ages, including neonates/infants, pre-pubertal children, and adolescents. As importantly, the response to neuroprotective therapies or treatments can differ between male and females subjects. These sex differences can result from several biologic origins, and may manifest differently during the various phases of brain and body development. Recognizing and understanding these potential sex differences is crucial, and should be considered in both preclinical and clinical studies of pediatric TBI. |
| doi_str_mv | 10.1016/j.expneurol.2019.02.016 |
| format | Article |
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There are critical developmental trajectories in the young brain, whereby injury can lead to long term functional abnormalities. Emerging preclinical and clinical literature supports the presence of significant sex differences in both the response to and the recovery from pediatric traumatic brain injury (TBI). These sex differences are seen at all pediatric ages, including neonates/infants, pre-pubertal children, and adolescents. As importantly, the response to neuroprotective therapies or treatments can differ between male and females subjects. These sex differences can result from several biologic origins, and may manifest differently during the various phases of brain and body development. Recognizing and understanding these potential sex differences is crucial, and should be considered in both preclinical and clinical studies of pediatric TBI.</description><identifier>ISSN: 0014-4886</identifier><identifier>EISSN: 1090-2430</identifier><identifier>DOI: 10.1016/j.expneurol.2019.02.016</identifier><identifier>PMID: 30831070</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Animals ; Brain Injuries, Traumatic ; Cerebral metabolism ; Child ; Child, Preschool ; Excitotoxicity ; Female ; Gender ; Humans ; Infant ; Infant, Newborn ; Male ; Mitochondria ; Neuroinflammation ; Sex ; Sex Characteristics</subject><ispartof>Experimental neurology, 2019-07, Vol.317, p.168-179</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. 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There are critical developmental trajectories in the young brain, whereby injury can lead to long term functional abnormalities. Emerging preclinical and clinical literature supports the presence of significant sex differences in both the response to and the recovery from pediatric traumatic brain injury (TBI). These sex differences are seen at all pediatric ages, including neonates/infants, pre-pubertal children, and adolescents. As importantly, the response to neuroprotective therapies or treatments can differ between male and females subjects. These sex differences can result from several biologic origins, and may manifest differently during the various phases of brain and body development. Recognizing and understanding these potential sex differences is crucial, and should be considered in both preclinical and clinical studies of pediatric TBI.</description><subject>Adolescent</subject><subject>Animals</subject><subject>Brain Injuries, Traumatic</subject><subject>Cerebral metabolism</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Excitotoxicity</subject><subject>Female</subject><subject>Gender</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Mitochondria</subject><subject>Neuroinflammation</subject><subject>Sex</subject><subject>Sex Characteristics</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAQhC0EouXxF6BHLglrJ_HjgoQQL6kSB-BsOc4aXKVJsRME_x5XhQpOnGztzM6sPkJOKeQUKD9f5Pix6nAMfZszoCoHlqf5DplSUJCxsoBdMgWgZVZKySfkIMYFAKiSiX0yKUAWFARMSfGIH7PGO4cBO4tx5rvZChtvhuDtbAhmXJoh_epgkuK7xRg-j8ieM23E4-_3kDzfXD9d3WXzh9v7q8t5ZktRDZlTwqQOSTkKlFRBU3OJjApXKSlEUmxTGOYcVcgFOFsDVoJXqmbcKu6KQ3KxyV2N9RIbi126p9Wr4JcmfOreeP1X6fyrfunftaBQ0ZKngLPvgNC_jRgHvfTRYtuaDvsxakalZFDJiiar2Fht6GMM6LY1FPQauV7oLXK9Rq6B6TRPmye_r9zu_TBOhsuNAROrd49BR-vXsBsf0A666f2_JV-6mZeK</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Arambula, Sheryl E.</creator><creator>Reinl, Erin L.</creator><creator>El Demerdash, Nagat</creator><creator>McCarthy, Margaret M.</creator><creator>Robertson, Courtney L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190701</creationdate><title>Sex differences in pediatric traumatic brain injury</title><author>Arambula, Sheryl E. ; Reinl, Erin L. ; El Demerdash, Nagat ; McCarthy, Margaret M. ; Robertson, Courtney L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-f97a070816e7e8190db68e217f59877708cd3a2ff19e670fcb0e57659b26c96f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Animals</topic><topic>Brain Injuries, Traumatic</topic><topic>Cerebral metabolism</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Excitotoxicity</topic><topic>Female</topic><topic>Gender</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Mitochondria</topic><topic>Neuroinflammation</topic><topic>Sex</topic><topic>Sex Characteristics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arambula, Sheryl E.</creatorcontrib><creatorcontrib>Reinl, Erin L.</creatorcontrib><creatorcontrib>El Demerdash, Nagat</creatorcontrib><creatorcontrib>McCarthy, Margaret M.</creatorcontrib><creatorcontrib>Robertson, Courtney L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arambula, Sheryl E.</au><au>Reinl, Erin L.</au><au>El Demerdash, Nagat</au><au>McCarthy, Margaret M.</au><au>Robertson, Courtney L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex differences in pediatric traumatic brain injury</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>317</volume><spage>168</spage><epage>179</epage><pages>168-179</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><abstract>The response of the developing brain to traumatic injury is different from the response of the mature, adult brain. There are critical developmental trajectories in the young brain, whereby injury can lead to long term functional abnormalities. Emerging preclinical and clinical literature supports the presence of significant sex differences in both the response to and the recovery from pediatric traumatic brain injury (TBI). These sex differences are seen at all pediatric ages, including neonates/infants, pre-pubertal children, and adolescents. As importantly, the response to neuroprotective therapies or treatments can differ between male and females subjects. These sex differences can result from several biologic origins, and may manifest differently during the various phases of brain and body development. Recognizing and understanding these potential sex differences is crucial, and should be considered in both preclinical and clinical studies of pediatric TBI.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30831070</pmid><doi>10.1016/j.expneurol.2019.02.016</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Experimental neurology, 2019-07, Vol.317, p.168-179 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Animals Brain Injuries, Traumatic Cerebral metabolism Child Child, Preschool Excitotoxicity Female Gender Humans Infant Infant, Newborn Male Mitochondria Neuroinflammation Sex Sex Characteristics |
| title | Sex differences in pediatric traumatic brain injury |
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