Relationship between CD14-159C/T gene polymorphism and acute brucellosis risk
Objective:To investigate the association between the cluster of differentiation 14(CD14)-I59C/T(rs2569190) gene polymorphism and susceptibility to acute brucellosis in an Iranian population.Methods:The study included 153 Iranian patients with active brucellosis and 128 healthy individuals as the con...
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| Veröffentlicht in: | Asian Pacific journal of tropical medicine 2016-03, Vol.9 (3), p.241-245 |
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| creator | Moghadampour, Mehdi Eskandari-Nasab, Ebrahim Shabani, Fatemeh |
| description | Objective:To investigate the association between the cluster of differentiation 14(CD14)-I59C/T(rs2569190) gene polymorphism and susceptibility to acute brucellosis in an Iranian population.Methods:The study included 153 Iranian patients with active brucellosis and 128 healthy individuals as the control group.Genotyping of the CD 14 variant was performed using an amplification refractory mutation system-polymerase chain reaction method.Results:The prevalence of CD14-159 TT and CT genotypes were associated with increased risk of brucellosis[odds ratio(OR)=l.993.95%confidence interval(95%CD=1.07-3.71.P=0.03 for CT:OR=3.869.95%CI= 1.91-7.84,P=0.01 for TT genotype.Additionally,the minor allele(T) was significantly more frequently present in brucellosis patients than in controls(61%vs.45%.respectively),and was a risk factor for brucellosis(OR=3.058.95%CI= 1.507-6.315.P=0.01).Condusions:The findings provid suggestive evidence of association of the CDI4-159C/T gene polymorphism with susceptibility to acute brucellosis in the Iranian population. |
| doi_str_mv | 10.1016/j.apjtm.2016.01.036 |
| format | Article |
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Production and hosting by Elsevier B.V. All rights reserved.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>Copyright © 2016 Hainan Medical College. Published by Elsevier B.V. 2016 Hainan Medical College</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c571t-7fef1d7a5a8911abed2bf2ee070653ce23c65887a7c486c5514497041f4a15e83</citedby><cites>FETCH-LOGICAL-c571t-7fef1d7a5a8911abed2bf2ee070653ce23c65887a7c486c5514497041f4a15e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/71792X/71792X.jpg</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.apjtm.2016.01.036$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26972395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moghadampour, Mehdi</creatorcontrib><creatorcontrib>Eskandari-Nasab, Ebrahim</creatorcontrib><creatorcontrib>Shabani, Fatemeh</creatorcontrib><title>Relationship between CD14-159C/T gene polymorphism and acute brucellosis risk</title><title>Asian Pacific journal of tropical medicine</title><addtitle>Asian Pacific Journal of Tropical Medicine</addtitle><description>Objective:To investigate the association between the cluster of differentiation 14(CD14)-I59C/T(rs2569190) gene polymorphism and susceptibility to acute brucellosis in an Iranian population.Methods:The study included 153 Iranian patients with active brucellosis and 128 healthy individuals as the control group.Genotyping of the CD 14 variant was performed using an amplification refractory mutation system-polymerase chain reaction method.Results:The prevalence of CD14-159 TT and CT genotypes were associated with increased risk of brucellosis[odds ratio(OR)=l.993.95%confidence interval(95%CD=1.07-3.71.P=0.03 for CT:OR=3.869.95%CI= 1.91-7.84,P=0.01 for TT genotype.Additionally,the minor allele(T) was significantly more frequently present in brucellosis patients than in controls(61%vs.45%.respectively),and was a risk factor for brucellosis(OR=3.058.95%CI= 1.507-6.315.P=0.01).Condusions:The findings provid suggestive evidence of association of the CDI4-159C/T gene polymorphism with susceptibility to acute brucellosis in the Iranian population.</description><subject>14;Single</subject><subject>Acute</subject><subject>Acute brucellosis</subject><subject>brucellosis;Cluster</subject><subject>Cluster of differentiation 14</subject><subject>differentiation</subject><subject>nucleotide</subject><subject>polymorphism</subject><subject>Single nucleotide polymorphism</subject><issn>1995-7645</issn><issn>2352-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNUV1rFDEUHUSxS-0vEGQeRZhtPifJg4Js1QoVQepzyGbu7GadSabJTMv015vtdos-aV5Cbs4959x7iuI1RkuMcH2-W5phN_ZLkh9LhJeI1s-KBaGcVAyz-nmxwErxStSMnxRnKe1QPpQoJejL4oTUShCq-KL49gM6M7rg09YN5RrGOwBfri4wqzBXq_PrcgMeyiF0cx_isHWpL41vSmOnEcp1nCx0XUguldGlX6-KF63pEpw93qfFz8-frleX1dX3L19XH68qywUeK9FCixthuJEKY7OGhqxbAoAEqjm1QKituZTCCMtkbTnHjCmBGG6ZwRwkPS0-HHiHad1DY8GP0XR6iK43cdbBOP33j3dbvQm3WmDEFFWZ4N2B4M741viN3oUp-mxZz7GZ5_t7DfvNIoqQyOC3j2ox3EyQRt27tJ_beAhT0lgopLjC6n-ggjIiqUAZSg9QG0NKEdon-xjpfcZ6px8y1nsnGmGdM85db_6c_KnnmGgGvD8AIO__1kHUyTrwFhoXwY66Ce4fAkdb2-A3Ny7v5qghlWSSSMURk0xxxmQOJpd4TX8D377HUQ</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Moghadampour, Mehdi</creator><creator>Eskandari-Nasab, Ebrahim</creator><creator>Shabani, Fatemeh</creator><general>Elsevier B.V</general><general>Department of Microbiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran</general><general>Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran%Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran</general><general>Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran%School of Medicine, Jiroft University of Medical Sciences, Jiroft, Kerman, Iran</general><general>Hainan Medical College. 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| subjects | 14 Single Acute Acute brucellosis brucellosis Cluster Cluster of differentiation 14 differentiation nucleotide polymorphism Single nucleotide polymorphism |
| title | Relationship between CD14-159C/T gene polymorphism and acute brucellosis risk |
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