Engineered bacteriophages as programmable biocontrol agents
[Display omitted] •Engineered bacteriophages are promising tools for use in food biotechnology.•Diverse natural bacteriophages can be leveraged by engineering for specificity and infectivity.•Engineered bacteriophages are potent tools for pathogen biocontrol.•Engineered bacteriophages can be used fo...
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| Veröffentlicht in: | Current opinion in biotechnology 2020-02, Vol.61, p.116-121 |
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| container_title | Current opinion in biotechnology |
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| creator | Huss, Phil Raman, Srivatsan |
| description | [Display omitted]
•Engineered bacteriophages are promising tools for use in food biotechnology.•Diverse natural bacteriophages can be leveraged by engineering for specificity and infectivity.•Engineered bacteriophages are potent tools for pathogen biocontrol.•Engineered bacteriophages can be used for targeted delivery vectors and pathogen detection.
Bacteriophages (or ‘phages’) can be potent biocontrol agents but their potential has not been fully realized due to inherent limitations of natural phages. By leveraging new tools in synthetic biology, natural phages can be engineered to overcome these limitations to markedly improve their efficacy and programmability. Engineered phages can be used for targeted detection and removal of pathogens, in situ microbiome editing, gene delivery and programmable control of phage-bacterial interactions. In this mini review we examine different ways natural phages can be engineered as effective biocontrol agents through a design-build-test-learn platform and identify novel applications of engineered phages in food biotechnology. |
| doi_str_mv | 10.1016/j.copbio.2019.11.013 |
| format | Article |
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•Engineered bacteriophages are promising tools for use in food biotechnology.•Diverse natural bacteriophages can be leveraged by engineering for specificity and infectivity.•Engineered bacteriophages are potent tools for pathogen biocontrol.•Engineered bacteriophages can be used for targeted delivery vectors and pathogen detection.
Bacteriophages (or ‘phages’) can be potent biocontrol agents but their potential has not been fully realized due to inherent limitations of natural phages. By leveraging new tools in synthetic biology, natural phages can be engineered to overcome these limitations to markedly improve their efficacy and programmability. Engineered phages can be used for targeted detection and removal of pathogens, in situ microbiome editing, gene delivery and programmable control of phage-bacterial interactions. In this mini review we examine different ways natural phages can be engineered as effective biocontrol agents through a design-build-test-learn platform and identify novel applications of engineered phages in food biotechnology.</description><identifier>ISSN: 0958-1669</identifier><identifier>EISSN: 1879-0429</identifier><identifier>DOI: 10.1016/j.copbio.2019.11.013</identifier><identifier>PMID: 31862543</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>bacteriophages ; biological control agents ; food biotechnology ; gene transfer ; microbiome ; pathogens ; synthetic biology</subject><ispartof>Current opinion in biotechnology, 2020-02, Vol.61, p.116-121</ispartof><rights>2019 The Authors</rights><rights>Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><rights>2019 The Authors 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-77dd996ec147c5f0ca239273d9811236129d8bde82be3d6d9e056689acd3ed923</citedby><cites>FETCH-LOGICAL-c496t-77dd996ec147c5f0ca239273d9811236129d8bde82be3d6d9e056689acd3ed923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0958166919301296$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31862543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huss, Phil</creatorcontrib><creatorcontrib>Raman, Srivatsan</creatorcontrib><title>Engineered bacteriophages as programmable biocontrol agents</title><title>Current opinion in biotechnology</title><addtitle>Curr Opin Biotechnol</addtitle><description>[Display omitted]
•Engineered bacteriophages are promising tools for use in food biotechnology.•Diverse natural bacteriophages can be leveraged by engineering for specificity and infectivity.•Engineered bacteriophages are potent tools for pathogen biocontrol.•Engineered bacteriophages can be used for targeted delivery vectors and pathogen detection.
Bacteriophages (or ‘phages’) can be potent biocontrol agents but their potential has not been fully realized due to inherent limitations of natural phages. By leveraging new tools in synthetic biology, natural phages can be engineered to overcome these limitations to markedly improve their efficacy and programmability. Engineered phages can be used for targeted detection and removal of pathogens, in situ microbiome editing, gene delivery and programmable control of phage-bacterial interactions. In this mini review we examine different ways natural phages can be engineered as effective biocontrol agents through a design-build-test-learn platform and identify novel applications of engineered phages in food biotechnology.</description><subject>bacteriophages</subject><subject>biological control agents</subject><subject>food biotechnology</subject><subject>gene transfer</subject><subject>microbiome</subject><subject>pathogens</subject><subject>synthetic biology</subject><issn>0958-1669</issn><issn>1879-0429</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkU9P4zAQxS0Egi7wDRDKkUuCx07sWEgrrVDZXQmJC5wtx562rpI42CkS355ULX_2spzmMG_em5kfIRdAC6AgrteFDUPjQ8EoqAKgoMAPyAxqqXJaMnVIZlRVdQ5CqBPyI6U1pbTikh6TEw61YFXJZ-Rm3i99jxjRZY2xI0YfhpVZYspMyoYYltF0nWlazKYsG_oxhjab-v2YzsjRwrQJz_f1lDzdzR9v_-T3D7__3v66z22pxJhL6ZxSAi2U0lYLag3jiknuVA3AuACmXN04rFmD3AmnkFZC1MpYx9Epxk_Jz53vsGk6dHbKjqbVQ_Sdia86GK__7fR-pZfhRUugXFZyMrjaG8TwvME06s4ni21regybpFk5PaSUUtbfSzlTknPFt9JyJ7UxpBRx8bERUL1FpNd6h0hvEWkAPSGaxi6_XvMx9M7k81ycfvriMepkPfYWnY9oR-2C_3_CG81fpRU</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Huss, Phil</creator><creator>Raman, Srivatsan</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>202002</creationdate><title>Engineered bacteriophages as programmable biocontrol agents</title><author>Huss, Phil ; Raman, Srivatsan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-77dd996ec147c5f0ca239273d9811236129d8bde82be3d6d9e056689acd3ed923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>bacteriophages</topic><topic>biological control agents</topic><topic>food biotechnology</topic><topic>gene transfer</topic><topic>microbiome</topic><topic>pathogens</topic><topic>synthetic biology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huss, Phil</creatorcontrib><creatorcontrib>Raman, Srivatsan</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current opinion in biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huss, Phil</au><au>Raman, Srivatsan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Engineered bacteriophages as programmable biocontrol agents</atitle><jtitle>Current opinion in biotechnology</jtitle><addtitle>Curr Opin Biotechnol</addtitle><date>2020-02</date><risdate>2020</risdate><volume>61</volume><spage>116</spage><epage>121</epage><pages>116-121</pages><issn>0958-1669</issn><eissn>1879-0429</eissn><abstract>[Display omitted]
•Engineered bacteriophages are promising tools for use in food biotechnology.•Diverse natural bacteriophages can be leveraged by engineering for specificity and infectivity.•Engineered bacteriophages are potent tools for pathogen biocontrol.•Engineered bacteriophages can be used for targeted delivery vectors and pathogen detection.
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| ispartof | Current opinion in biotechnology, 2020-02, Vol.61, p.116-121 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | bacteriophages biological control agents food biotechnology gene transfer microbiome pathogens synthetic biology |
| title | Engineered bacteriophages as programmable biocontrol agents |
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