Postpartum breast cancer progression is driven by semaphorin 7a-mediated invasion and survival

Young women diagnosed with breast cancer (BC) have poor prognosis due to increased rates of metastasis. In addition, women diagnosed within 10 years of most recent childbirth are approximately three times more likely to develop metastasis than age- and stage-matched nulliparous women. We define thes...

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Veröffentlicht in:	Oncogene 2020-03, Vol.39 (13), p.2772-2785
Hauptverfasser:	Tarullo, Sarah E., Hill, Ryan C., Hansen, Kirk C., Behbod, Fariba, Borges, Virginia F., Nelson, Andrew C., Lyons, Traci R.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/51 631/67/1347 631/67/327 64/60 82/58 82/80 Animals Antigens, CD - genetics Antigens, CD - metabolism Apoptosis Breast - pathology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - pathology Care and treatment Cell Biology Cell Line, Tumor Cell survival Cell Survival - genetics Cohort Studies Collagen Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Development and progression Disease Progression Female Fibronectin Fibronectins - metabolism Gene expression Gene Knockdown Techniques Genetic aspects GPI-Linked Proteins - genetics GPI-Linked Proteins - metabolism Health aspects Human Genetics Humans Internal Medicine Kaplan-Meier Estimate Mammary gland Mammary Glands, Human - pathology Medical prognosis Medicine Medicine & Public Health Metastases Metastasis Mice Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Oncology Postpartum Postpartum Period Pregnancy Prognosis Puerperium RNA, Small Interfering - metabolism Semaphorins Semaphorins - genetics Semaphorins - metabolism Tumor Microenvironment Womens health Xenograft Model Antitumor Assays
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