Extracellular barriers in respiratory gene therapy

Respiratory gene therapy has been considered for the treatment of a broad range of pulmonary disorders. However, respiratory secretions form an important barrier towards the pulmonary delivery of therapeutic nucleic acids. In this review we will start with a brief description of the biophysical prop...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Advanced drug delivery reviews 2009-02, Vol.61 (2), p.115-127
Hauptverfasser:	Sanders, Niek, Rudolph, Carsten, Braeckmans, Kevin, De Smedt, Stefaan C., Demeester, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bronchoalveolar Lavage Fluid - chemistry Diffusion Expectorants - administration & dosage Expectorants - therapeutic use Gene Transfer Techniques Genetic Therapy Humans Lung Diseases - therapy Models, Biological Mucus - chemistry Mucus - physiology Mucus Alveolar fluid Nanoparticles - administration & dosage NANs Nucleic acid containing nanoparticles Nucleic Acids - administration & dosage Respiratory gene therapy Respiratory Mucosa - chemistry Respiratory Mucosa - metabolism Respiratory Mucosa - physiology Sputum - chemistry Sputum - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!