Extracellular barriers in respiratory gene therapy
Respiratory gene therapy has been considered for the treatment of a broad range of pulmonary disorders. However, respiratory secretions form an important barrier towards the pulmonary delivery of therapeutic nucleic acids. In this review we will start with a brief description of the biophysical prop...
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| Veröffentlicht in: | Advanced drug delivery reviews 2009-02, Vol.61 (2), p.115-127 |
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| container_title | Advanced drug delivery reviews |
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| creator | Sanders, Niek Rudolph, Carsten Braeckmans, Kevin De Smedt, Stefaan C. Demeester, Joseph |
| description | Respiratory gene therapy has been considered for the treatment of a broad range of pulmonary disorders. However, respiratory secretions form an important barrier towards the pulmonary delivery of therapeutic nucleic acids. In this review we will start with a brief description of the biophysical properties of respiratory mucus and alveolar fluid. This must allow the reader to gain insights into the mechanisms by which respiratory secretions may impede the gene transfer efficiency of nucleic acid containing nanoparticles (NANs). Subsequently, we will summarize the efforts that have been done to understand the barrier properties of respiratory mucus and alveolar fluid towards the respiratory delivery of therapeutic nucleic acids. Finally, new and current strategies that can overcome the inhibitory effects of respiratory secretions are discussed. |
| doi_str_mv | 10.1016/j.addr.2008.09.011 |
| format | Article |
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| ispartof | Advanced drug delivery reviews, 2009-02, Vol.61 (2), p.115-127 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Bronchoalveolar Lavage Fluid - chemistry Diffusion Expectorants - administration & dosage Expectorants - therapeutic use Gene Transfer Techniques Genetic Therapy Humans Lung Diseases - therapy Models, Biological Mucus - chemistry Mucus - physiology Mucus Alveolar fluid Nanoparticles - administration & dosage NANs Nucleic acid containing nanoparticles Nucleic Acids - administration & dosage Respiratory gene therapy Respiratory Mucosa - chemistry Respiratory Mucosa - metabolism Respiratory Mucosa - physiology Sputum - chemistry Sputum - metabolism |
| title | Extracellular barriers in respiratory gene therapy |
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