G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer

Purpose The combination of targeting the CDK4/6 and estrogen receptor (ER) signaling pathways with palbociclib and fulvestrant is a proven therapeutic strategy for the treatment of ER-positive breast cancer. However, the poor physicochemical properties of fulvestrant require monthly intramuscular in...

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Veröffentlicht in:	Breast cancer research and treatment 2020-04, Vol.180 (3), p.635-646
Hauptverfasser:	Andreano, Kaitlyn J., Wardell, Suzanne E., Baker, Jennifer G., Desautels, Taylor K., Baldi, Robert, Chao, Christina A., Heetderks, Kendall A., Bae, Yeeun, Xiong, Rui, Tonetti, Debra A., Gutgesell, Lauren M., Zhao, Jiong, Sorrentino, Jessica A., Thompson, Delita A., Bisi, John E., Strum, Jay C., Thatcher, Gregory R. J., Norris, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibodies, Monoclonal, Humanized - pharmacology Antiestrogens Antineoplastic Combined Chemotherapy Protocols - pharmacology Antitumor activity Apoptosis - drug effects Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer research Care and treatment Cell proliferation Cell Proliferation - drug effects Cyclin-dependent kinase 4 Cyclin-Dependent Kinase 4 - antagonists & inhibitors Cyclin-Dependent Kinase 6 - antagonists & inhibitors Drug Resistance, Neoplasm Drug therapy Endocrine therapy Estrogen Estrogen Antagonists - pharmacology Estrogen receptors Female Fulvestrant Growth Health aspects HIV Antibodies - pharmacology Humans Medical colleges Medicine Medicine & Public Health Mice Neoplasms, Hormone-Dependent - drug therapy Neoplasms, Hormone-Dependent - metabolism Neoplasms, Hormone-Dependent - pathology Oncology Patients Pharmacodynamics Pharmacokinetics Phenols Physicochemical properties Preclinical Study Protein Kinase Inhibitors - pharmacology Receptors, Estrogen - metabolism Selective Estrogen Receptor Modulators - pharmacology Tamoxifen Tamoxifen - pharmacology Transcription Tumor Cells, Cultured Tumors Xenograft Model Antitumor Assays Xenografts
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