Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells

Automated patch clamp (APC) instruments enable efficient evaluation of electrophysiologic effects of drugs on human cardiac currents in heterologous expression systems. Differences in experimental protocols, instruments, and dissimilar site procedures affect the variability of IC 50 values character...

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Veröffentlicht in:	Scientific reports 2020-03, Vol.10 (1), p.5627, Article 5627
Hauptverfasser:	Kramer, James, Himmel, Herbert M., Lindqvist, Anders, Stoelzle-Feix, Sonja, Chaudhary, Khuram W., Li, Dingzhou, Bohme, Georg Andrees, Bridgland-Taylor, Matthew, Hebeisen, Simon, Fan, Jingsong, Renganathan, Muthukrishnan, Imredy, John, Humphries, Edward S. A., Brinkwirth, Nina, Strassmaier, Tim, Ohtsuki, Atsushi, Danker, Timm, Vanoye, Carlos, Polonchuk, Liudmila, Fermini, Bernard, Pierson, Jennifer Beck, Gintant, Gary
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154 631/154/1435 631/154/1438 631/154/436 692/4019 Automation Drugs Heart Humanities and Social Sciences multidisciplinary Risk assessment Science Science (multidisciplinary)
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