In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography

Imaging techniques for quantifying changes in the hierarchical structure of deforming joints are constrained by destructive sample treatments, sample-size restrictions and lengthy scan times. Here, we report the use of fast low-dose pink-beam synchrotron X-ray tomography in combination with mechanic...

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Veröffentlicht in:	Nature biomedical engineering 2020-03, Vol.4 (3), p.343-354
Hauptverfasser:	Madi, Kamel, Staines, Katherine A., Bay, Brian K., Javaheri, Behzad, Geng, Hua, Bodey, Andrew J., Cartmell, Sarah, Pitsillides, Andrew A., Lee, Peter D.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/811 639/166/985 639/766/930/2735 692/699/1670/407 Animals Biomechanics Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedical materials Biomedicine Cartilage Cartilage diseases Cellular structure Chondrocytes Chondrocytes - ultrastructure Imaging techniques Imaging, Three-Dimensional Joints - diagnostic imaging Joints - ultrastructure Male Mechanical loading Mechanical properties Mechanical stimuli Mice Nanostructures Osteoarthritis Osteoarthritis - diagnostic imaging Osteoarthritis - pathology Stiffness Strain Stress, Mechanical Structural hierarchy Synchrotron radiation Synchrotrons Tomography Tomography, X-Ray - methods X ray imagery
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