Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of end-stage renal disease (ESRD). The treatment options for ADPKD are limited. We observed an upregulation in several IGF-1 pathway genes in the kidney of Pkd1RC/RC mice, a model of ADPKD. Pregnancy-associated pla...

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Veröffentlicht in:	JCI insight 2020-02, Vol.5 (4)
Hauptverfasser:	Kashyap, Sonu, Hein, Kyaw Zaw, Chini, Claudia Cs, Lika, Jorgo, Warner, Gina M, Bale, Laurie K, Torres, Vicente E, Harris, Peter C, Oxvig, Claus, Conover, Cheryl A, Chini, Eduardo N
Format:	Artikel
Sprache:	eng
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