Loss of circadian gene Bmal1 in the collecting duct lowers blood pressure in male, but not female, mice

Kidney function follows a 24-h rhythm subject to regulation by circadian genes including the transcription factor . A high-salt diet induces a phase shift in expression in the renal inner medulla that is dependent on endothelin type B (ET ) receptors. Furthermore, ET receptor-mediated natriuresis is...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2020-03, Vol.318 (3), p.F710-F719
Hauptverfasser:	Zhang, Dingguo, Jin, Chunhua, Obi, Ijeoma E, Rhoads, Megan K, Soliman, Reham H, Sedaka, Randee S, Allan, J Miller, Tao, Binli, Speed, Joshua S, Pollock, Jennifer S, Pollock, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldosterone - metabolism Aldosterone - urine Animals ARNTL Transcription Factors - genetics ARNTL Transcription Factors - metabolism Blood pressure Blood Pressure - physiology BMAL1 protein Circadian rhythms Collecting duct Diet Endothelins Female Flox Gene expression Gene Expression Regulation - physiology Gene regulation Genotypes Kidney Tubules, Collecting - metabolism Male Mice Mice, Knockout Potassium - urine Pressure dependence Receptor, Endothelin B - genetics Receptor, Endothelin B - metabolism Receptors Rodents Sex Sex Factors Sodium Sodium - metabolism Sodium - urine Sodium chloride Sodium Chloride, Dietary - administration & dosage Telemetry
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