Myocardin and myocardin-related transcription factor-A synergistically mediate actin cytoskeletal-dependent inhibition of liver fibrogenesis

Activation of hepatic stellate cells (HSCs), characterized by development of a robust actin cytoskeleton and expression of abundant extracellular matrix (ECM) proteins, such as type 1 collagen (COL.1), is a central cellular and molecular event in liver fibrosis. It has been demonstrated that HSCs ex...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2020-03, Vol.318 (3), p.G504-G517
Hauptverfasser:	Shi, Zengdun, Ren, Mudan, Rockey, Don C
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actin Cytoskeleton - drug effects Actin Cytoskeleton - genetics Actin Cytoskeleton - metabolism Actin Cytoskeleton - pathology Animals Cell activation Cell adhesion & migration Cell migration Cell Movement - drug effects Cell Proliferation - drug effects Cells, Cultured Chemical and Drug Induced Liver Injury - genetics Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - prevention & control Collagen Collagen Type I - genetics Collagen Type I - metabolism Contractility Contraction Cytoskeleton Extracellular matrix Extracellular Matrix - drug effects Extracellular Matrix - metabolism Extracellular Matrix - pathology Extracellular Signal-Regulated MAP Kinases - metabolism Fibrosis Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - pathology Liver Liver - drug effects Liver - metabolism Liver - pathology Liver Cirrhosis, Experimental - genetics Liver Cirrhosis, Experimental - metabolism Liver Cirrhosis, Experimental - pathology Liver Cirrhosis, Experimental - prevention & control Male Mice, Inbred BALB C Nipecotic Acids - pharmacology Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclear transport Phosphorylation Rats, Sprague-Dawley Serum response factor Signal Transduction Smad Proteins, Receptor-Regulated - metabolism Smad2 protein Stellate cells Therapeutic applications Time Factors Trans-Activators - genetics Trans-Activators - metabolism Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Up-Regulation
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