Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance

Understanding the neural components modulating feeding-related behavior and energy expenditure is crucial to combating obesity and its comorbidities. Neurons within the paraventricular nucleus of the hypothalamus (PVH) are a key component of the satiety response; activation of the PVH decreases feed...

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Veröffentlicht in:	Scientific reports 2020-03, Vol.10 (1), p.5546-5546, Article 5546
Hauptverfasser:	Sutton, Amy K., Gonzalez, Ian E., Sadagurski, Marianna, Rajala, Michael, Lu, Chunxia, Allison, Margaret B., Adams, Jessica M., Myers, Martin G., White, Morris F., Olson, David P.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/319/1488/1562 631/443/319/1557 64 64/60 Animals Energy Energy balance Energy expenditure Energy Metabolism Feeding behavior Female Gene Knockdown Techniques Hindbrain Humanities and Social Sciences Hypothalamus Insulin Insulin Receptor Substrate Proteins - genetics Male Melanocortin Melanocortin MC4 receptors Mice multidisciplinary Neurons Neurons - metabolism Nitric oxide Nitric Oxide Synthase Type I - metabolism Nitric-oxide synthase Obesity Obesity - genetics Obesity - metabolism Oxytocin Paraventricular Hypothalamic Nucleus - metabolism Paraventricular nucleus Prodynorphin Receptors, Oxytocin - metabolism Satiety Science Science (multidisciplinary) Subpopulations
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