Association of PPM1G methylation with risk-taking in alcohol use disorder
Alcohol use disorder (AUD) is a chronic and relapsing disease with a substantial genetic influence. Given the recent discovery of the association of PPM1G methylation with alcohol use disorder (AUD) from a genome-wide methylation study, we sought to verify and extend the previous work of AUD-related...
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| Veröffentlicht in: | Scientific reports 2020-03, Vol.10 (1), p.5490, Article 5490 |
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| description | Alcohol use disorder (AUD) is a chronic and relapsing disease with a substantial genetic influence. Given the recent discovery of the association of
PPM1G
methylation with alcohol use disorder (AUD) from a genome-wide methylation study, we sought to verify and extend the previous work of AUD-related impulsivity in a Korean population with AUD. A total of 244 men with AUD were assessed for psychological characteristics and behavioral impulsivity using stop signal task (response inhibition) and Balloon Analog Risk Task (risk-taking). Leukocyte DNA methylation at
PPM1G
was quantified using pyrosequencing. The effects of
PPM1G
methylation on severity of problematic drinking measured by Alcohol Use Disorder Identification Test (AUDIT) and multidimensional impulsivity were tested using linear regression analyses. Hypermethylation of
PPM1G
was significantly associated with risk-taking propensity among men with AUD. No significant association of
PPM1G
methylation was found to be associated with AUDIT scores and response inhibition. Our findings indicate that altered methylation of
PPM1G
may influence the impulsive choice of risk-taking in AUD. Further research is required in order to determine the role of
PPM1G
in the pathophysiology of AUD and multidimensional impulsivity. |
| doi_str_mv | 10.1038/s41598-020-62504-y |
| format | Article |
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PPM1G
methylation with alcohol use disorder (AUD) from a genome-wide methylation study, we sought to verify and extend the previous work of AUD-related impulsivity in a Korean population with AUD. A total of 244 men with AUD were assessed for psychological characteristics and behavioral impulsivity using stop signal task (response inhibition) and Balloon Analog Risk Task (risk-taking). Leukocyte DNA methylation at
PPM1G
was quantified using pyrosequencing. The effects of
PPM1G
methylation on severity of problematic drinking measured by Alcohol Use Disorder Identification Test (AUDIT) and multidimensional impulsivity were tested using linear regression analyses. Hypermethylation of
PPM1G
was significantly associated with risk-taking propensity among men with AUD. No significant association of
PPM1G
methylation was found to be associated with AUDIT scores and response inhibition. Our findings indicate that altered methylation of
PPM1G
may influence the impulsive choice of risk-taking in AUD. Further research is required in order to determine the role of
PPM1G
in the pathophysiology of AUD and multidimensional impulsivity.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-62504-y</identifier><identifier>PMID: 32218500</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38/23 ; 631/208/176 ; 692/53/2421 ; Adult ; Alcohol use ; Alcoholism - genetics ; Alcoholism - metabolism ; Alcoholism - psychology ; Alcohols ; DNA Methylation ; Drinking behavior ; Epigenesis, Genetic ; Genomes ; Humanities and Social Sciences ; Humans ; Impulsive Behavior ; Impulsivity ; Linear Models ; Male ; Middle Aged ; multidisciplinary ; Protein Phosphatase 2C - genetics ; Republic of Korea ; Risk taking ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2020-03, Vol.10 (1), p.5490, Article 5490</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-a133eb3a2a0f49fea05481efa8b808100acda93759cb32126611218b99656bb73</citedby><cites>FETCH-LOGICAL-c522t-a133eb3a2a0f49fea05481efa8b808100acda93759cb32126611218b99656bb73</cites><orcidid>0000-0003-0119-0443 ; 0000-0002-5438-8210 ; 0000-0002-2818-7183 ; 0000-0002-9321-8361</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099006/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099006/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32218500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Chun Il</creatorcontrib><creatorcontrib>Kim, Hae Won</creatorcontrib><creatorcontrib>Hwang, Syung Shick</creatorcontrib><creatorcontrib>Kang, Jee In</creatorcontrib><creatorcontrib>Kim, Se Joo</creatorcontrib><title>Association of PPM1G methylation with risk-taking in alcohol use disorder</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Alcohol use disorder (AUD) is a chronic and relapsing disease with a substantial genetic influence. Given the recent discovery of the association of
PPM1G
methylation with alcohol use disorder (AUD) from a genome-wide methylation study, we sought to verify and extend the previous work of AUD-related impulsivity in a Korean population with AUD. A total of 244 men with AUD were assessed for psychological characteristics and behavioral impulsivity using stop signal task (response inhibition) and Balloon Analog Risk Task (risk-taking). Leukocyte DNA methylation at
PPM1G
was quantified using pyrosequencing. The effects of
PPM1G
methylation on severity of problematic drinking measured by Alcohol Use Disorder Identification Test (AUDIT) and multidimensional impulsivity were tested using linear regression analyses. Hypermethylation of
PPM1G
was significantly associated with risk-taking propensity among men with AUD. No significant association of
PPM1G
methylation was found to be associated with AUDIT scores and response inhibition. Our findings indicate that altered methylation of
PPM1G
may influence the impulsive choice of risk-taking in AUD. Further research is required in order to determine the role of
PPM1G
in the pathophysiology of AUD and multidimensional impulsivity.</description><subject>38/23</subject><subject>631/208/176</subject><subject>692/53/2421</subject><subject>Adult</subject><subject>Alcohol use</subject><subject>Alcoholism - genetics</subject><subject>Alcoholism - metabolism</subject><subject>Alcoholism - psychology</subject><subject>Alcohols</subject><subject>DNA Methylation</subject><subject>Drinking behavior</subject><subject>Epigenesis, Genetic</subject><subject>Genomes</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Impulsive Behavior</subject><subject>Impulsivity</subject><subject>Linear Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Protein Phosphatase 2C - genetics</subject><subject>Republic of Korea</subject><subject>Risk taking</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9UcFOAjEQbYxGCPIDHswmnlen7XZpLyaEKJJg5KDnprt0obBssV00-_dWFxEvzmUmM2_evMxD6BLDDQbKb32CmeAxEIhTwiCJmxPUJZCwmFBCTo_qDup7v4IQjIgEi3PUCV3MGUAXTYbe29yo2tgqskU0mz3hcbTR9bIp2-aHqZeRM34d12ptqkVkqkiVuV3aMtp5Hc2Nt26u3QU6K1TpdX-fe-j14f5l9BhPn8eT0XAa54yQOlaYUp1RRRQUiSi0ApZwrAvFMw4cA6h8rgQdMJFnlGCSphgHsZkQKUuzbEB76K7l3e6yjZ7nuqqdKuXWmY1yjbTKyL-Tyizlwr7LAQgBkAaC6z2Bs2877Wu5sjtXBc2SUE6TAcepCCjSonJnvXe6OFzAIL8ckK0DMjggvx2QTVi6OtZ2WPn5dwDQFuDDqFpo93v7H9pPgL-RqQ</recordid><startdate>20200326</startdate><enddate>20200326</enddate><creator>Park, Chun Il</creator><creator>Kim, Hae Won</creator><creator>Hwang, Syung Shick</creator><creator>Kang, Jee In</creator><creator>Kim, Se Joo</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0119-0443</orcidid><orcidid>https://orcid.org/0000-0002-5438-8210</orcidid><orcidid>https://orcid.org/0000-0002-2818-7183</orcidid><orcidid>https://orcid.org/0000-0002-9321-8361</orcidid></search><sort><creationdate>20200326</creationdate><title>Association of PPM1G methylation with risk-taking in alcohol use disorder</title><author>Park, Chun Il ; Kim, Hae Won ; Hwang, Syung Shick ; Kang, Jee In ; Kim, Se Joo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-a133eb3a2a0f49fea05481efa8b808100acda93759cb32126611218b99656bb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>38/23</topic><topic>631/208/176</topic><topic>692/53/2421</topic><topic>Adult</topic><topic>Alcohol use</topic><topic>Alcoholism - genetics</topic><topic>Alcoholism - metabolism</topic><topic>Alcoholism - psychology</topic><topic>Alcohols</topic><topic>DNA Methylation</topic><topic>Drinking behavior</topic><topic>Epigenesis, Genetic</topic><topic>Genomes</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Impulsive Behavior</topic><topic>Impulsivity</topic><topic>Linear Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Protein Phosphatase 2C - genetics</topic><topic>Republic of Korea</topic><topic>Risk taking</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Chun Il</creatorcontrib><creatorcontrib>Kim, Hae Won</creatorcontrib><creatorcontrib>Hwang, Syung Shick</creatorcontrib><creatorcontrib>Kang, Jee In</creatorcontrib><creatorcontrib>Kim, Se Joo</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Chun Il</au><au>Kim, Hae Won</au><au>Hwang, Syung Shick</au><au>Kang, Jee In</au><au>Kim, Se Joo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of PPM1G methylation with risk-taking in alcohol use disorder</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-03-26</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>5490</spage><pages>5490-</pages><artnum>5490</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Alcohol use disorder (AUD) is a chronic and relapsing disease with a substantial genetic influence. Given the recent discovery of the association of
PPM1G
methylation with alcohol use disorder (AUD) from a genome-wide methylation study, we sought to verify and extend the previous work of AUD-related impulsivity in a Korean population with AUD. A total of 244 men with AUD were assessed for psychological characteristics and behavioral impulsivity using stop signal task (response inhibition) and Balloon Analog Risk Task (risk-taking). Leukocyte DNA methylation at
PPM1G
was quantified using pyrosequencing. The effects of
PPM1G
methylation on severity of problematic drinking measured by Alcohol Use Disorder Identification Test (AUDIT) and multidimensional impulsivity were tested using linear regression analyses. Hypermethylation of
PPM1G
was significantly associated with risk-taking propensity among men with AUD. No significant association of
PPM1G
methylation was found to be associated with AUDIT scores and response inhibition. Our findings indicate that altered methylation of
PPM1G
may influence the impulsive choice of risk-taking in AUD. Further research is required in order to determine the role of
PPM1G
in the pathophysiology of AUD and multidimensional impulsivity.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32218500</pmid><doi>10.1038/s41598-020-62504-y</doi><orcidid>https://orcid.org/0000-0003-0119-0443</orcidid><orcidid>https://orcid.org/0000-0002-5438-8210</orcidid><orcidid>https://orcid.org/0000-0002-2818-7183</orcidid><orcidid>https://orcid.org/0000-0002-9321-8361</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 38/23 631/208/176 692/53/2421 Adult Alcohol use Alcoholism - genetics Alcoholism - metabolism Alcoholism - psychology Alcohols DNA Methylation Drinking behavior Epigenesis, Genetic Genomes Humanities and Social Sciences Humans Impulsive Behavior Impulsivity Linear Models Male Middle Aged multidisciplinary Protein Phosphatase 2C - genetics Republic of Korea Risk taking Science Science (multidisciplinary) |
| title | Association of PPM1G methylation with risk-taking in alcohol use disorder |
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