Down-regulation of protease-activated receptor 2 ameliorated osteoarthritis in rats through regulation of MAPK/NF-κB signaling pathway in vivo and in vitro

Recently, protease-activated receptor 2 (PAR2) has been proved to be involved in the inflammatory response including osteoarthritis (OA). In the present study, we found that PAR2 antagonist could remarkably improve the pathological condition of OA rats in vivo. In addition, we also found that PAR2 a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioscience reports 2020-03, Vol.40 (3)
Hauptverfasser:	Yan, Shichang, Ding, Huimin, Peng, Junyang, Wang, Xinqiang, Pang, Chenglong, Wei, Juncheng, Wei, Jianjun, Chen, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biotechnology Cell Homeostasis & Autophagy China Chondrocytes - metabolism Cyclooxygenase 2 - metabolism Diagnostics & Biomarkers Female Male MAP Kinase Signaling System - drug effects Matrix Metalloproteinase 1 - metabolism Matrix Metalloproteinase 13 - metabolism NF-kappa B - genetics Osteoarthritis - metabolism Osteoarthritis - physiopathology p38 Mitogen-Activated Protein Kinases - metabolism Rats Rats, Sprague-Dawley Receptor, PAR-2 - antagonists & inhibitors Receptor, PAR-2 - genetics Receptor, PAR-2 - metabolism Signal Transduction - drug effects Tumor Necrosis Factor-alpha - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!