Animal models of multiple sclerosis: the good, the bad and the bottom line

Multiple sclerosis is a debilitating inflammatory demyelinating disease of the CNS. In this perspective, the author examines the strengths and weaknesses of the numerous animal models that are currently being used to analyze the pathogenesis of this disease with an eye toward the precise pathologica...

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Veröffentlicht in:	Nature neuroscience 2012-08, Vol.15 (8), p.1074-1077
1. Verfasser:	Ransohoff, Richard M
Format:	Artikel
Sprache:	eng
Schlagworte:	19th century 631/1647/767/1424 631/378/340 692/699/375/1411/1666 Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Diagnosis Disease Models, Animal Disease susceptibility Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - physiopathology Epstein-Barr virus Humans Multiple sclerosis Multiple Sclerosis - immunology Multiple Sclerosis - physiopathology Neurobiology Neurosciences Pathogenesis Pathology perspective Risk factors
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