Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy

Globular glial tauopathy (GGT) is a progressive neurodegenerative disease involving the grey matter and white matter (WM) and characterized by neuronal deposition of hyper-phosphorylated, abnormally conformed, truncated, oligomeric 4Rtau in neurons and in glial cells forming typical globular astrocy...

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Veröffentlicht in:	Acta neuropathologica 2020-04, Vol.139 (4), p.735-771
Hauptverfasser:	Ferrer, Isidro, Andrés-Benito, Pol, Zelaya, Maria Victoria, Aguirre, Maria Elena Erro, Carmona, Margarita, Ausín, Karina, Lachén-Montes, Mercedes, Fernández-Irigoyen, Joaquín, Santamaría, Enrique, del Rio, José Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Antibodies Brain Brain - metabolism Brain - pathology Comparative analysis Connexin 43 Corpus callosum Cortex (frontal) Female Gap junctions Genetic aspects Genetic research Glial cells Glial fibrillary acidic protein Glucose transporter Glutamate Glutamic acid transporter Humans Immunohistochemistry Inoculation Male Medicine Medicine & Public Health Mice Mice, Inbred C57BL Middle Aged Mitochondria Morphogenesis Mutation Myelin Myelin proteolipid protein Myelin-associated glycoprotein Nervous system diseases Neurodegenerative diseases Neuroglia - metabolism Neuroglia - pathology Neuronal-glial interactions Neurons Neurons - metabolism Neurons - pathology Neurosciences Oligodendrocyte-myelin glycoprotein Original Paper Pathology Phenotypes Phosphorylation Proteins Proteomics Substantia alba Substantia grisea Synaptic transmission tau Proteins - genetics tau Proteins - metabolism Tauopathies - genetics Tauopathies - metabolism Tauopathies - pathology Western blotting
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