Structural and genetic basis for development of broadly neutralizing influenza antibodies

The events leading to the generation of broadly neutralizing antibodies to influenza viruses, which may hold the key to developing a universal flu vaccine, are elucidated. Vaccine-friendly anti-influenza antibodies The study of broadly neutralizing antibodies to influenza virus may pave the way for...

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Veröffentlicht in:	Nature 2012-09, Vol.489 (7417), p.566-570
Hauptverfasser:	Lingwood, Daniel, McTamney, Patrick M., Yassine, Hadi M., Whittle, James R. R., Guo, Xiaoti, Boyington, Jeffrey C., Wei, Chih-Jen, Nabel, Gary J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/248 631/250/2152/2153/1291 631/326/596/1578 Amino Acid Sequence Amino acids Antibodies Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - genetics Antibodies, Neutralizing - immunology Antibodies, Viral - chemistry Antibodies, Viral - genetics Antibodies, Viral - immunology Antibody Affinity - immunology Binding Sites, Antibody - immunology Biological and medical sciences Complementarity Determining Regions - chemistry Complementarity Determining Regions - immunology Cross Reactions - immunology Fundamental and applied biological sciences. Psychology Genetic aspects Health aspects Humanities and Social Sciences Humans Immunoglobulin G - chemistry Immunoglobulin G - immunology Immunoglobulin Heavy Chains - chemistry Immunoglobulin Heavy Chains - immunology Immunoglobulin M - chemistry Immunoglobulin M - immunology Infectious diseases Influenza Influenza vaccines Influenza Vaccines - immunology letter Light Microbiology Models, Molecular Molecular Sequence Data multidisciplinary Mutation Neutralization Orthomyxoviridae - chemistry Orthomyxoviridae - classification Orthomyxoviridae - immunology Prevention Protein Conformation Proteins Receptors, Antigen, B-Cell - chemistry Receptors, Antigen, B-Cell - immunology Science Science (multidisciplinary) Sequence Alignment Testing Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Viral antibodies Virology
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