IL-27 Is Elevated in Patients With COPD and Patients With Pulmonary TB and Induces Human Bronchial Epithelial Cells to Produce CXCL10

Background The role of IL-27 in the pathogenesis of airway inflammatory diseases remains elusive. We, therefore, have studied its concentrations in the sputum and plasma of patients with COPD and patients with pulmonary TB (PTB), and further investigated the mechanism-of-action effects of IL-27 on b...

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Veröffentlicht in:	Chest 2012, Vol.141 (1), p.121-130
Hauptverfasser:	Cao, Ju, PhD, Zhang, Liping, PhD, Li, Dairong, MD, Xu, Fang, MD, Huang, Shifeng, PhD, Xiang, Yu, MD, Yin, Yibing, MD, Ren, Guosheng, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial diseases Bacterial diseases of the respiratory system Biological and medical sciences Bronchi - metabolism Bronchi - pathology Cardiology. Vascular system Chemokine CXCL10 - biosynthesis Chemokine CXCL10 - genetics Chronic obstructive pulmonary disease, asthma DNA - genetics Enzyme-Linked Immunosorbent Assay Epithelial Cells - metabolism Female Gene Expression Regulation Human bacterial diseases Humans Infectious diseases Interleukins - metabolism Male Medical sciences Middle Aged Original Research Pneumology Pulmonary Disease, Chronic Obstructive - genetics Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - pathology Pulmonary/Respiratory Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Sputum - chemistry Sputum - cytology Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - genetics Tuberculosis, Pulmonary - metabolism Tuberculosis, Pulmonary - pathology
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