African trypanosomiasis: Sensitive and rapid detection of the sub-genus Trypanozoon by loop-mediated isothermal amplification (LAMP) of parasite DNA

Control of human African trypanosomiasis (HAT) is dependent on accurate diagnosis and treatment of infected patients. However, sensitivities of tests in routine use are unsatisfactory, due to the characteristically low parasitaemias in naturally infected individuals. We have identified a conserved s...

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Veröffentlicht in:	International journal for parasitology 2008-04, Vol.38 (5), p.589-599
Hauptverfasser:	Njiru, Z.K., Mikosza, A.S.J., Matovu, E., Enyaru, J.C.K., Ouma, J.O., Kibona, S.N., Thompson, R.C.A., Ndung’u, J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Diagnosis DNA, Protozoan - analysis Fundamental and applied biological sciences. Psychology Genes, Protozoan Humans Interspersed Repetitive Sequences Life cycle. Host-agent relationship. Pathogenesis Loop-mediated isothermal amplification Nucleic Acid Amplification Techniques - methods Polymerase Chain Reaction - methods Protozoa Sensitivity and Specificity Sleeping sickness Trypanosoma brucei gambiense - classification Trypanosoma brucei gambiense - genetics Trypanosoma brucei gambiense - isolation & purification Trypanosoma brucei rhodesiense Trypanosomiasis, African - diagnosis Trypanosomiasis, African - parasitology Trypanozoon
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