Circumpapillary and macular vessel density assessment by optical coherence tomography angiography in eyes with temporal hemianopia from chiasmal compression. Correlation with retinal neural and visual field loss
Aims To compare the circumpapillary and macular vessel density (cpVD/mVD) of eyes with temporal visual field (VF) defect and band atrophy (BA) of the optic nerve and normal controls using OCTA and to verify the association of VD parameters with circumpapillary retinal nerve fibre layer (cpRNFL) thic...
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| Veröffentlicht in: | Eye (London) 2020-04, Vol.34 (4), p.695-703 |
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| creator | Suzuki, Ana Claudia F. Zacharias, Leandro C. Preti, Rony C. Cunha, Leonardo P. Monteiro, Mário L. R. |
| description | Aims
To compare the circumpapillary and macular vessel density (cpVD/mVD) of eyes with temporal visual field (VF) defect and band atrophy (BA) of the optic nerve and normal controls using OCTA and to verify the association of VD parameters with circumpapillary retinal nerve fibre layer (cpRNFL) thickness, macular ganglion cell complex (mGCC) thickness and VF loss.
Methods
Thirty-three eyes of 26 patients with BA and 42 eyes of 22 age-matched normal controls underwent OCT + OCTA scanning. cpVD and cpRNFL were expressed as average and sector measurements. mVD and mGCC were calculated as averages and in quadrants and hemiretinas. VF loss was estimated using the 24-2 and the 10-2 protocols. Generalized estimated equation models were used for comparisons and area under the receiver operating characteristics (AROC) were calculated.
Results
Compared with controls, BA eyes displayed smaller average cpVD and mVD values (
p
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| doi_str_mv | 10.1038/s41433-019-0564-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7093447</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2475008927</sourcerecordid><originalsourceid>FETCH-LOGICAL-c498t-14a392441700e10afea1aaff610527c5025f0eef0f0071353e41666ffab73b803</originalsourceid><addsrcrecordid>eNp9kkuLFDEQxxtR3HH0A3iRgBcvvVZe_bgIMviCBS8K3ppMT2U6Sydpk-6R-Zx-IWuc3fUBekqK-tW_KpV_UTzlcMlBNi-z4krKEnhbgq5UKe4VK67qqtRKq_vFCloNpRDiy0XxKOdrAErW8LC4kFxLxRu9Kr5vXOoXP5nJjaNJR2bCjnnTLxSwA-aMI9thyG6mFEU5ewwz2x5ZnGbXm5H1ccCEoUc2Rx_3yUzDSWXvbu8uMDxiZt_cPLAZ_RQTlQ3onQlxcobZFD3rB2ey_6nnp0R9XAyXbBNTwtHMFJzrE84uEBVwOamcpj24vNDVOhx3bIw5Py4eWDNmfHJzrovPb9982rwvrz6--7B5fVX2qm3mkisjW6EUrwGQg7FouDHWVhy0qHsNQltAtGABai61RMWrqrLWbGu5bUCui1dn3WnZetz1tBiaqZuS87TJLhrX_ZkJbuj28dDV0EqlahJ4cSOQ4tcF89x5l3ukjwgYl9wJ0cq25lpoQp__hV7HJdEmiFK1BmhaUf-Xko2ogEPTEMXPVJ9oWwnt3cgcupOxurOxOjJWdzIWFa-LZ7-_9a7i1kkEiDOQKRX2mH61_rfqD6KM31E</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2382601088</pqid></control><display><type>article</type><title>Circumpapillary and macular vessel density assessment by optical coherence tomography angiography in eyes with temporal hemianopia from chiasmal compression. Correlation with retinal neural and visual field loss</title><source>Springer Nature - Complete Springer Journals</source><source>PubMed Central</source><creator>Suzuki, Ana Claudia F. ; Zacharias, Leandro C. ; Preti, Rony C. ; Cunha, Leonardo P. ; Monteiro, Mário L. R.</creator><creatorcontrib>Suzuki, Ana Claudia F. ; Zacharias, Leandro C. ; Preti, Rony C. ; Cunha, Leonardo P. ; Monteiro, Mário L. R.</creatorcontrib><description>Aims
To compare the circumpapillary and macular vessel density (cpVD/mVD) of eyes with temporal visual field (VF) defect and band atrophy (BA) of the optic nerve and normal controls using OCTA and to verify the association of VD parameters with circumpapillary retinal nerve fibre layer (cpRNFL) thickness, macular ganglion cell complex (mGCC) thickness and VF loss.
Methods
Thirty-three eyes of 26 patients with BA and 42 eyes of 22 age-matched normal controls underwent OCT + OCTA scanning. cpVD and cpRNFL were expressed as average and sector measurements. mVD and mGCC were calculated as averages and in quadrants and hemiretinas. VF loss was estimated using the 24-2 and the 10-2 protocols. Generalized estimated equation models were used for comparisons and area under the receiver operating characteristics (AROC) were calculated.
Results
Compared with controls, BA eyes displayed smaller average cpVD and mVD values (
p
< 0.001 and AROC = 0.91 for both). Sectorial measurements were also reduced, especially the nasotemporal sector average cpVD (
p
< 0.001 and AROC = 0.96) and the nasal retina mVD measurements (
p
< 0.001 and AROC = 0.93). cpVD and mVD correlated strongly with corresponding cpRNFL and mGCC thickness measurements in affected regions (
r
range: 0.67–0.78 and 0.56–0.76, respectively). Similarly, cpVD and mVD parameters correlated significantly with corresponding VF loss (
r
range: 0.45–0.68).
Conclusions
cpVD and mVD are significantly reduced in BA eyes compared with controls and are strongly correlated with retinal neural and VF loss. cpVD and mVD reduction on OCTA could serve as a surrogate for retinal neural loss in compressive optic neuropathy and might be useful in its management.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/s41433-019-0564-2</identifier><identifier>PMID: 31534185</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/378/2613/1786 ; 692/1807/1482 ; Angiography ; Atrophy ; Compression ; Eye ; Laboratory Medicine ; Medicine ; Medicine & Public Health ; Ophthalmology ; Optic nerve ; Optic neuropathy ; Pharmaceutical Sciences/Technology ; Retina ; Surgery ; Surgical Oncology ; Vision ; Visual field</subject><ispartof>Eye (London), 2020-04, Vol.34 (4), p.695-703</ispartof><rights>The Author(s), under exclusive licence to The Royal College of Ophthalmologists 2019</rights><rights>2019© The Author(s), under exclusive licence to The Royal College of Ophthalmologists 2019</rights><rights>The Author(s), under exclusive licence to The Royal College of Ophthalmologists 2019.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-14a392441700e10afea1aaff610527c5025f0eef0f0071353e41666ffab73b803</citedby><cites>FETCH-LOGICAL-c498t-14a392441700e10afea1aaff610527c5025f0eef0f0071353e41666ffab73b803</cites><orcidid>0000-0002-7281-2791</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093447/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093447/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,41467,42536,51297,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31534185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suzuki, Ana Claudia F.</creatorcontrib><creatorcontrib>Zacharias, Leandro C.</creatorcontrib><creatorcontrib>Preti, Rony C.</creatorcontrib><creatorcontrib>Cunha, Leonardo P.</creatorcontrib><creatorcontrib>Monteiro, Mário L. R.</creatorcontrib><title>Circumpapillary and macular vessel density assessment by optical coherence tomography angiography in eyes with temporal hemianopia from chiasmal compression. Correlation with retinal neural and visual field loss</title><title>Eye (London)</title><addtitle>Eye</addtitle><addtitle>Eye (Lond)</addtitle><description>Aims
To compare the circumpapillary and macular vessel density (cpVD/mVD) of eyes with temporal visual field (VF) defect and band atrophy (BA) of the optic nerve and normal controls using OCTA and to verify the association of VD parameters with circumpapillary retinal nerve fibre layer (cpRNFL) thickness, macular ganglion cell complex (mGCC) thickness and VF loss.
Methods
Thirty-three eyes of 26 patients with BA and 42 eyes of 22 age-matched normal controls underwent OCT + OCTA scanning. cpVD and cpRNFL were expressed as average and sector measurements. mVD and mGCC were calculated as averages and in quadrants and hemiretinas. VF loss was estimated using the 24-2 and the 10-2 protocols. Generalized estimated equation models were used for comparisons and area under the receiver operating characteristics (AROC) were calculated.
Results
Compared with controls, BA eyes displayed smaller average cpVD and mVD values (
p
< 0.001 and AROC = 0.91 for both). Sectorial measurements were also reduced, especially the nasotemporal sector average cpVD (
p
< 0.001 and AROC = 0.96) and the nasal retina mVD measurements (
p
< 0.001 and AROC = 0.93). cpVD and mVD correlated strongly with corresponding cpRNFL and mGCC thickness measurements in affected regions (
r
range: 0.67–0.78 and 0.56–0.76, respectively). Similarly, cpVD and mVD parameters correlated significantly with corresponding VF loss (
r
range: 0.45–0.68).
Conclusions
cpVD and mVD are significantly reduced in BA eyes compared with controls and are strongly correlated with retinal neural and VF loss. cpVD and mVD reduction on OCTA could serve as a surrogate for retinal neural loss in compressive optic neuropathy and might be useful in its management.</description><subject>631/378/2613/1786</subject><subject>692/1807/1482</subject><subject>Angiography</subject><subject>Atrophy</subject><subject>Compression</subject><subject>Eye</subject><subject>Laboratory Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Optic nerve</subject><subject>Optic neuropathy</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Retina</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Vision</subject><subject>Visual field</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kkuLFDEQxxtR3HH0A3iRgBcvvVZe_bgIMviCBS8K3ppMT2U6Sydpk-6R-Zx-IWuc3fUBekqK-tW_KpV_UTzlcMlBNi-z4krKEnhbgq5UKe4VK67qqtRKq_vFCloNpRDiy0XxKOdrAErW8LC4kFxLxRu9Kr5vXOoXP5nJjaNJR2bCjnnTLxSwA-aMI9thyG6mFEU5ewwz2x5ZnGbXm5H1ccCEoUc2Rx_3yUzDSWXvbu8uMDxiZt_cPLAZ_RQTlQ3onQlxcobZFD3rB2ey_6nnp0R9XAyXbBNTwtHMFJzrE84uEBVwOamcpj24vNDVOhx3bIw5Py4eWDNmfHJzrovPb9982rwvrz6--7B5fVX2qm3mkisjW6EUrwGQg7FouDHWVhy0qHsNQltAtGABai61RMWrqrLWbGu5bUCui1dn3WnZetz1tBiaqZuS87TJLhrX_ZkJbuj28dDV0EqlahJ4cSOQ4tcF89x5l3ukjwgYl9wJ0cq25lpoQp__hV7HJdEmiFK1BmhaUf-Xko2ogEPTEMXPVJ9oWwnt3cgcupOxurOxOjJWdzIWFa-LZ7-_9a7i1kkEiDOQKRX2mH61_rfqD6KM31E</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Suzuki, Ana Claudia F.</creator><creator>Zacharias, Leandro C.</creator><creator>Preti, Rony C.</creator><creator>Cunha, Leonardo P.</creator><creator>Monteiro, Mário L. R.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7281-2791</orcidid></search><sort><creationdate>20200401</creationdate><title>Circumpapillary and macular vessel density assessment by optical coherence tomography angiography in eyes with temporal hemianopia from chiasmal compression. Correlation with retinal neural and visual field loss</title><author>Suzuki, Ana Claudia F. ; Zacharias, Leandro C. ; Preti, Rony C. ; Cunha, Leonardo P. ; Monteiro, Mário L. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-14a392441700e10afea1aaff610527c5025f0eef0f0071353e41666ffab73b803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>631/378/2613/1786</topic><topic>692/1807/1482</topic><topic>Angiography</topic><topic>Atrophy</topic><topic>Compression</topic><topic>Eye</topic><topic>Laboratory Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Optic nerve</topic><topic>Optic neuropathy</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Retina</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Vision</topic><topic>Visual field</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzuki, Ana Claudia F.</creatorcontrib><creatorcontrib>Zacharias, Leandro C.</creatorcontrib><creatorcontrib>Preti, Rony C.</creatorcontrib><creatorcontrib>Cunha, Leonardo P.</creatorcontrib><creatorcontrib>Monteiro, Mário L. R.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzuki, Ana Claudia F.</au><au>Zacharias, Leandro C.</au><au>Preti, Rony C.</au><au>Cunha, Leonardo P.</au><au>Monteiro, Mário L. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circumpapillary and macular vessel density assessment by optical coherence tomography angiography in eyes with temporal hemianopia from chiasmal compression. Correlation with retinal neural and visual field loss</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>34</volume><issue>4</issue><spage>695</spage><epage>703</epage><pages>695-703</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><abstract>Aims
To compare the circumpapillary and macular vessel density (cpVD/mVD) of eyes with temporal visual field (VF) defect and band atrophy (BA) of the optic nerve and normal controls using OCTA and to verify the association of VD parameters with circumpapillary retinal nerve fibre layer (cpRNFL) thickness, macular ganglion cell complex (mGCC) thickness and VF loss.
Methods
Thirty-three eyes of 26 patients with BA and 42 eyes of 22 age-matched normal controls underwent OCT + OCTA scanning. cpVD and cpRNFL were expressed as average and sector measurements. mVD and mGCC were calculated as averages and in quadrants and hemiretinas. VF loss was estimated using the 24-2 and the 10-2 protocols. Generalized estimated equation models were used for comparisons and area under the receiver operating characteristics (AROC) were calculated.
Results
Compared with controls, BA eyes displayed smaller average cpVD and mVD values (
p
< 0.001 and AROC = 0.91 for both). Sectorial measurements were also reduced, especially the nasotemporal sector average cpVD (
p
< 0.001 and AROC = 0.96) and the nasal retina mVD measurements (
p
< 0.001 and AROC = 0.93). cpVD and mVD correlated strongly with corresponding cpRNFL and mGCC thickness measurements in affected regions (
r
range: 0.67–0.78 and 0.56–0.76, respectively). Similarly, cpVD and mVD parameters correlated significantly with corresponding VF loss (
r
range: 0.45–0.68).
Conclusions
cpVD and mVD are significantly reduced in BA eyes compared with controls and are strongly correlated with retinal neural and VF loss. cpVD and mVD reduction on OCTA could serve as a surrogate for retinal neural loss in compressive optic neuropathy and might be useful in its management.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31534185</pmid><doi>10.1038/s41433-019-0564-2</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7281-2791</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Eye (London), 2020-04, Vol.34 (4), p.695-703 |
| issn | 0950-222X 1476-5454 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7093447 |
| source | Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | 631/378/2613/1786 692/1807/1482 Angiography Atrophy Compression Eye Laboratory Medicine Medicine Medicine & Public Health Ophthalmology Optic nerve Optic neuropathy Pharmaceutical Sciences/Technology Retina Surgery Surgical Oncology Vision Visual field |
| title | Circumpapillary and macular vessel density assessment by optical coherence tomography angiography in eyes with temporal hemianopia from chiasmal compression. Correlation with retinal neural and visual field loss |
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