Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss

von Hippel-Lindau (VHL) is a critical tumor suppressor in clear cell renal cell carcinomas (ccRCCs). It is important to identify additional therapeutic targets in ccRCC downstream of VHL loss besides hypoxia-inducible factor 2α (HIF2α). By performing a genome-wide screen, we identified Scm-like with...

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Veröffentlicht in:	Molecular cell 2020-03, Vol.77 (6), p.1294-1306.e5
Hauptverfasser:	Liu, Xijuan, Simon, Jeremy M., Xie, Haibiao, Hu, Lianxin, Wang, Jun, Zurlo, Giada, Fan, Cheng, Ptacek, Travis S., Herring, Laura, Tan, Xianming, Li, Mingjie, Baldwin, Albert S., Kim, William Y., Wu, Tao, Kirschner, Marc W., Gong, Kan, Zhang, Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism brain neoplasms carcinoma Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology ccRCC Cell Cycle Cell Movement Cell Proliferation chromatin immunoprecipitation enzymes Gene Expression Regulation, Neoplastic genes Genome-Wide Association Study Humans hydroxylation Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidney Neoplasms - pathology loss-of-function mutation Mice Mice, Inbred NOD Mice, SCID patients phenotype Phosphotransferases (Alcohol Group Acceptor) - genetics Phosphotransferases (Alcohol Group Acceptor) - metabolism Prognosis Prolyl Hydroxylases - genetics Prolyl Hydroxylases - metabolism protein content pVHL repressor proteins Repressor Proteins - genetics Repressor Proteins - metabolism screening sequence analysis SFMBT1 sphingosine SPHK1 therapeutics Tumor Cells, Cultured Ubiquitination Von Hippel-Lindau Tumor Suppressor Protein - genetics Von Hippel-Lindau Tumor Suppressor Protein - metabolism Xenograft Model Antitumor Assays
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