CD34+ cell dose and establishment of full donor chimerism at day +100 are important factors for survival with reduced-intensity conditioning with fludarabine and melphalan before allogeneic hematopoietic SCT for hematologic malignancies

The combination of fludarabine and melphalan as a reduced-intensity conditioning (RIC) regimen extends allogeneic hematopoietic SCT (HSCT) as a therapeutic option for elderly or frail patients with relapsed, refractory or other high-risk hematologic malignancies. Whether any modifiable factors exist...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2010-12, Vol.45 (12), p.1699-1703
Hauptverfasser:	Holtan, S G, Hogan, W J, Elliott, M A, Ansell, S M, Inwards, D J, Porrata, L F, Johnston, P B, Micallef, I N, Lacy, M Q, Gastineau, D A, Litzow, M R
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1990 692/53/2422 692/700/565/545/576/1955 Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens, CD34 - immunology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Blood cancer Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction CD34 antigen Cell Biology Chimerism Combined Modality Therapy Conditioning Disease-Free Survival Dosage Female Fludarabine Hematologic Neoplasms - drug therapy Hematologic Neoplasms - surgery Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cells - immunology Humans Internal Medicine Lymphocytes Male Medical prognosis Medical records Medical sciences Medicine Medicine & Public Health Melphalan Melphalan - administration & dosage Middle Aged Multivariate analysis original-article Patients Public Health Retrospective Studies Risk Risk groups Stem cell transplantation Stem Cells Survival Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Chimera Transplantation Conditioning - methods Vidarabine - administration & dosage Vidarabine - analogs & derivatives Young Adult
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