Evaluation of the NAD+ biosynthetic pathway in ALS patients and effect of modulating NAD+ levels in hSOD1-linked ALS mouse models

Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of motor neurons. Astrocytes from diverse ALS models induce motor neuron death in co-culture. Enhancing NAD+ availability, or increasing the expression of the NAD+-dependent deacylases SIRT3 and SIRT6, abrogates their n...

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Veröffentlicht in:	Experimental neurology 2020-05, Vol.327, p.113219-113219, Article 113219
Hauptverfasser:	Harlan, Benjamin A., Killoy, Kelby M., Pehar, Mariana, Liu, Liping, Auwerx, Johan, Vargas, Marcelo R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Animals Astrocytes Biosynthetic Pathways - physiology Cells, Cultured Disease Models, Animal Humans Mice Mice, Transgenic Motor neurons Motor Neurons - metabolism Motor Neurons - pathology NAD - metabolism Nicotinamide Phosphoribosyltransferase - metabolism Nicotinamide riboside Nicotinamide-Nucleotide Adenylyltransferase - metabolism NMNAT2 SIRT3 SIRT6 Sirtuin 3 - metabolism Sirtuins - metabolism Spinal Cord - metabolism Spinal Cord - pathology Superoxide Dismutase-1 - genetics Superoxide Dismutase-1 - metabolism
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