Role of microbiota on lung homeostasis and diseases
The lungs, as a place of gas exchange, are continuously exposed to environmental stimuli, such as allergens, microbes, and pollutants. The development of the culture-independent technique for microbiological analysis, such as 16 S rRNA sequencing,has uncovered that the lungs are not sterile and, in...
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| Veröffentlicht in: | Science China. Life sciences 2017-12, Vol.60 (12), p.1407-1415 |
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| creator | Wang, Jian Li, Fengqi Tian, Zhigang |
| description | The lungs, as a place of gas exchange, are continuously exposed to environmental stimuli, such as allergens, microbes, and pollutants. The development of the culture-independent technique for microbiological analysis, such as 16 S rRNA sequencing,has uncovered that the lungs are not sterile and, in fact, colonized by diverse communities of microbiota. The function of intestinal microbiota in modulating mucosal homeostasis and defense has been widely studied; however, the potential function of lung microbiota in regulating immunity and homeostasis has just begun. Increasing evidence indicates the relevance of microbiota to lung homeostasis and disease. In this review, we describe the distribution and composition of microbiota in the respiratory system and discuss the potential function of lung microbiota in both health and acute/chronic lung disease. In addition, we also discuss the recent understanding of the gut-lung axis, because several studies have revealed that the immunological interaction among the gut, the lung, and the microbiota was involved in this issue. |
| doi_str_mv | 10.1007/s11427-017-9151-1 |
| format | Article |
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The development of the culture-independent technique for microbiological analysis, such as 16 S rRNA sequencing,has uncovered that the lungs are not sterile and, in fact, colonized by diverse communities of microbiota. The function of intestinal microbiota in modulating mucosal homeostasis and defense has been widely studied; however, the potential function of lung microbiota in regulating immunity and homeostasis has just begun. Increasing evidence indicates the relevance of microbiota to lung homeostasis and disease. In this review, we describe the distribution and composition of microbiota in the respiratory system and discuss the potential function of lung microbiota in both health and acute/chronic lung disease. In addition, we also discuss the recent understanding of the gut-lung axis, because several studies have revealed that the immunological interaction among the gut, the lung, and the microbiota was involved in this issue.</description><identifier>ISSN: 1674-7305</identifier><identifier>EISSN: 1869-1889</identifier><identifier>DOI: 10.1007/s11427-017-9151-1</identifier><identifier>PMID: 29019144</identifier><language>eng</language><publisher>Beijing: Science China Press</publisher><subject>Allergens ; Biomedical and Life Sciences ; Digestive system ; Dysbiosis - immunology ; Dysbiosis - physiopathology ; Environmental effects ; Gas exchange ; Gastrointestinal Microbiome - immunology ; Gastrointestinal Microbiome - physiology ; Gastrointestinal tract ; Homeostasis ; Humans ; Immunity, Mucosal - physiology ; Intestinal microflora ; Intestine ; Life Sciences ; Lung - immunology ; Lung - microbiology ; Lung - physiology ; Lung diseases ; Lung Diseases - immunology ; Lung Diseases - microbiology ; Lung Diseases - physiopathology ; Lungs ; Microbiota ; Microbiota - physiology ; Mucosa ; Pollutants ; Respiratory Physiological Phenomena ; Respiratory system ; Respiratory System - immunology ; Respiratory System - microbiology ; Review ; rRNA 16S</subject><ispartof>Science China. Life sciences, 2017-12, Vol.60 (12), p.1407-1415</ispartof><rights>Science China Press and Springer-Verlag GmbH Germany 2017</rights><rights>Science China Life Sciences is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-5d8dfc130f295a13b999644ba9135fa9b8f26ce2e0e1a458285bd7c592dced863</citedby><cites>FETCH-LOGICAL-c497t-5d8dfc130f295a13b999644ba9135fa9b8f26ce2e0e1a458285bd7c592dced863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/60112X/60112X.jpg</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11427-017-9151-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11427-017-9151-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29019144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jian</creatorcontrib><creatorcontrib>Li, Fengqi</creatorcontrib><creatorcontrib>Tian, Zhigang</creatorcontrib><title>Role of microbiota on lung homeostasis and diseases</title><title>Science China. Life sciences</title><addtitle>Sci. China Life Sci</addtitle><addtitle>Sci China Life Sci</addtitle><description>The lungs, as a place of gas exchange, are continuously exposed to environmental stimuli, such as allergens, microbes, and pollutants. The development of the culture-independent technique for microbiological analysis, such as 16 S rRNA sequencing,has uncovered that the lungs are not sterile and, in fact, colonized by diverse communities of microbiota. The function of intestinal microbiota in modulating mucosal homeostasis and defense has been widely studied; however, the potential function of lung microbiota in regulating immunity and homeostasis has just begun. Increasing evidence indicates the relevance of microbiota to lung homeostasis and disease. In this review, we describe the distribution and composition of microbiota in the respiratory system and discuss the potential function of lung microbiota in both health and acute/chronic lung disease. In addition, we also discuss the recent understanding of the gut-lung axis, because several studies have revealed that the immunological interaction among the gut, the lung, and the microbiota was involved in this issue.</description><subject>Allergens</subject><subject>Biomedical and Life Sciences</subject><subject>Digestive system</subject><subject>Dysbiosis - immunology</subject><subject>Dysbiosis - physiopathology</subject><subject>Environmental effects</subject><subject>Gas exchange</subject><subject>Gastrointestinal Microbiome - immunology</subject><subject>Gastrointestinal Microbiome - physiology</subject><subject>Gastrointestinal tract</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Immunity, Mucosal - physiology</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Life Sciences</subject><subject>Lung - immunology</subject><subject>Lung - microbiology</subject><subject>Lung - physiology</subject><subject>Lung diseases</subject><subject>Lung Diseases - immunology</subject><subject>Lung Diseases - microbiology</subject><subject>Lung Diseases - physiopathology</subject><subject>Lungs</subject><subject>Microbiota</subject><subject>Microbiota - physiology</subject><subject>Mucosa</subject><subject>Pollutants</subject><subject>Respiratory Physiological Phenomena</subject><subject>Respiratory system</subject><subject>Respiratory System - immunology</subject><subject>Respiratory System - microbiology</subject><subject>Review</subject><subject>rRNA 16S</subject><issn>1674-7305</issn><issn>1869-1889</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1LxDAQhoMo7qL7A7xI0YuXaiZpmsxFEPELBEH0HNI23a20idu0gv_eLLsu6sFcEjLPvPPxEnIE9BwolRcBIGMypSBTBAEp7JApqBxTUAp34zuXWSo5FRMyC-GNxsM5ZVLukwlDCghZNiX82bc28XXSNWXvi8YPJvEuaUc3Txa-sz4MJjQhMa5KqiZYE2w4JHu1aYOdbe4D8np783J9nz4-3T1cXz2mZYZySEWlqroETmuGwgAvEDHPssIgcFEbLFTN8tIySy2YTCimRFHJUiCrSlupnB-Qy7Xu-1h0Nn66oTetfu-bzvSf2ptG_464ZqHn_kNLqmINjAJnG4HeL0cbBt01obRta5z1Y9CAIq4PEVbo6R_0zY-9i-NFCjnNc6AsUrCm4q5C6G29bQaoXrmi167oKKtXrmiIOcc_p9hmfHsQAbYGQgy5ue1_lP5H9WTTycK7-TLmbYWj75wJBYp_ARBhokE</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Wang, Jian</creator><creator>Li, Fengqi</creator><creator>Tian, Zhigang</creator><general>Science China Press</general><general>Springer Nature B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171201</creationdate><title>Role of microbiota on lung homeostasis and diseases</title><author>Wang, Jian ; Li, Fengqi ; Tian, Zhigang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-5d8dfc130f295a13b999644ba9135fa9b8f26ce2e0e1a458285bd7c592dced863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Allergens</topic><topic>Biomedical and Life Sciences</topic><topic>Digestive system</topic><topic>Dysbiosis - immunology</topic><topic>Dysbiosis - physiopathology</topic><topic>Environmental effects</topic><topic>Gas exchange</topic><topic>Gastrointestinal Microbiome - immunology</topic><topic>Gastrointestinal Microbiome - physiology</topic><topic>Gastrointestinal tract</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Immunity, Mucosal - physiology</topic><topic>Intestinal microflora</topic><topic>Intestine</topic><topic>Life Sciences</topic><topic>Lung - immunology</topic><topic>Lung - microbiology</topic><topic>Lung - physiology</topic><topic>Lung diseases</topic><topic>Lung Diseases - immunology</topic><topic>Lung Diseases - microbiology</topic><topic>Lung Diseases - physiopathology</topic><topic>Lungs</topic><topic>Microbiota</topic><topic>Microbiota - physiology</topic><topic>Mucosa</topic><topic>Pollutants</topic><topic>Respiratory Physiological Phenomena</topic><topic>Respiratory system</topic><topic>Respiratory System - immunology</topic><topic>Respiratory System - microbiology</topic><topic>Review</topic><topic>rRNA 16S</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jian</creatorcontrib><creatorcontrib>Li, Fengqi</creatorcontrib><creatorcontrib>Tian, Zhigang</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science China. Life sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jian</au><au>Li, Fengqi</au><au>Tian, Zhigang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of microbiota on lung homeostasis and diseases</atitle><jtitle>Science China. Life sciences</jtitle><stitle>Sci. China Life Sci</stitle><addtitle>Sci China Life Sci</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>60</volume><issue>12</issue><spage>1407</spage><epage>1415</epage><pages>1407-1415</pages><issn>1674-7305</issn><eissn>1869-1889</eissn><abstract>The lungs, as a place of gas exchange, are continuously exposed to environmental stimuli, such as allergens, microbes, and pollutants. The development of the culture-independent technique for microbiological analysis, such as 16 S rRNA sequencing,has uncovered that the lungs are not sterile and, in fact, colonized by diverse communities of microbiota. The function of intestinal microbiota in modulating mucosal homeostasis and defense has been widely studied; however, the potential function of lung microbiota in regulating immunity and homeostasis has just begun. Increasing evidence indicates the relevance of microbiota to lung homeostasis and disease. In this review, we describe the distribution and composition of microbiota in the respiratory system and discuss the potential function of lung microbiota in both health and acute/chronic lung disease. In addition, we also discuss the recent understanding of the gut-lung axis, because several studies have revealed that the immunological interaction among the gut, the lung, and the microbiota was involved in this issue.</abstract><cop>Beijing</cop><pub>Science China Press</pub><pmid>29019144</pmid><doi>10.1007/s11427-017-9151-1</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Allergens Biomedical and Life Sciences Digestive system Dysbiosis - immunology Dysbiosis - physiopathology Environmental effects Gas exchange Gastrointestinal Microbiome - immunology Gastrointestinal Microbiome - physiology Gastrointestinal tract Homeostasis Humans Immunity, Mucosal - physiology Intestinal microflora Intestine Life Sciences Lung - immunology Lung - microbiology Lung - physiology Lung diseases Lung Diseases - immunology Lung Diseases - microbiology Lung Diseases - physiopathology Lungs Microbiota Microbiota - physiology Mucosa Pollutants Respiratory Physiological Phenomena Respiratory system Respiratory System - immunology Respiratory System - microbiology Review rRNA 16S |
| title | Role of microbiota on lung homeostasis and diseases |
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