Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy

Background Autophagy has been reported to play a pivotal role on the replication of various RNA viruses. In this study, we investigated the role of autophagy on hepatitis C virus (HCV) RNA replication and demonstrated anti-HCV effects of an autophagic proteolysis inhibitor, chloroquine. Methods Indu...

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Veröffentlicht in:	Journal of gastroenterology 2010-02, Vol.45 (2), p.195-203
Hauptverfasser:	Mizui, Tomokazu, Yamashina, Shunhei, Tanida, Isei, Takei, Yoshiyuki, Ueno, Takashi, Sakamoto, Naoya, Ikejima, Kenichi, Kitamura, Tsuneo, Enomoto, Nobuyuki, Sakai, Tatsuo, Kominami, Eiki, Watanabe, Sumio
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Surgery Analysis Antiviral Agents - administration & dosage Antiviral Agents - pharmacology Autophagy - drug effects Biliary Tract Biological response modifiers Cell Line, Tumor Chloroquine - administration & dosage Chloroquine - pharmacology Colorectal Surgery Dose-Response Relationship, Drug Drug Delivery Systems Drug Synergism Drug Therapy, Combination Gastroenterology Hepacivirus - drug effects Hepacivirus - metabolism Hepatitis C virus Hepatology Humans Infection Interferon Interferon-alpha - administration & dosage Medicine Medicine & Public Health Original Article—Liver Original —Liver, Pancreas, and Biliary Tract Pancreas Protease inhibitors Proteases Proteolysis RNA RNA, Small Interfering - administration & dosage Surgical Oncology Transfection Viral Proteins - drug effects Viral Proteins - metabolism Virus Replication - drug effects
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