Genome-wide Identification of Foxf2 Target Genes in Palate Development

Cleft palate is among the most common structural birth defects in humans. Previous studies have shown that mutations in FOXF2 are associated with cleft palate in humans and mice and that Foxf2 acts in a Shh-Foxf-Fgf18-Shh molecular network controlling palatal shelf growth. In this study, we combined...

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Veröffentlicht in:	Journal of dental research 2020-04, Vol.99 (4), p.463-471
Hauptverfasser:	Xu, J., Liu, H., Lan, Y., Park, J.S., Jiang, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Biological Phenomena Child Chondroitin sulfate Cleft lip/palate Cleft Palate - genetics Collagen (type I) Congenital defects Core protein Dentistry Embryos Extracellular matrix Fibroblast growth factor 18 Forkhead Transcription Factors Gene Expression Regulation, Developmental Genomes Glycosaminoglycans Humans Hybridization Keratan sulfate Mesenchyme Mice Mice, Inbred C57BL Morphogenesis Palate Polymerase chain reaction Proteoglycans Research Reports Ribonucleic acid RNA Sulfotransferase Transcription factors Versican
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