Qualitative and Quantitative Analysis of 24 Components in Jinlianhua Decoction by UPLC–MS/MS
Jinlianhua Decoction (JD), composed of Flos Trollii, Herba Taraxaci, Folium Isatidis, Radix Puerariae Lobatae, and Folium Perillae in a ratio of 6:15:10:10:6, is a prescription for Fengwen which is a group of febrile diseases due to wind in Chinese medicine. It was originally used for the prevention...
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| Veröffentlicht in: | Chromatographia 2019, Vol.82 (12), p.1801-1825 |
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| creator | Fang, Mingyue Liu, Shuangyue Wang, Qingqing Gu, Xuan Ding, Pengmin Wang, Weihua Ding, Yi Liu, Junxiu Wang, Rufeng |
| description | Jinlianhua Decoction (JD), composed of Flos Trollii, Herba Taraxaci, Folium Isatidis, Radix Puerariae Lobatae, and Folium Perillae in a ratio of 6:15:10:10:6, is a prescription for Fengwen which is a group of febrile diseases due to wind in Chinese medicine. It was originally used for the prevention and treatment of severe acute respiratory syndrome (SARS), and could also be used to treat influenza due to their common pathomechanism. To elucidate the unclear pharmacodynamic basis of JD, the LC-QExactive-MS system was used to qualitatively analyze its main components in this study. As a result, 89 compounds were identified and 24 important ones were selected thereby to further perform the simultaneous quantification in 8 batches of JD samples using LC-QTrap-MS with multiple reaction monitoring (MRM). Based on the qualitative and quantitative results in combination with the bioactivities reported, 16 compounds including orientin, 2″-
O
-β-
l
-galactopyranosylorientin, puerarin, trollisin I, rosmarinic acid, 2″-
O
-(2′″-methylbutanoyl) isoswertisin, daidzin, scutellarin, 3′-methoxy puerarin, vitexin, 3′-hydroxy puerarin, 2″-
O
-(2′″-methylbutanoyl) vitexin, kaempferol, caffeic acid, 3,4-dimethoxybenzoic acid, and cynaroside were determined as the major components of JD. This study provides a useful combinational method for analyzing the major pharmacodynamic substances of JD and lays a foundation for the quality control research of the decoction. |
| doi_str_mv | 10.1007/s10337-019-03806-w |
| format | Article |
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O
-β-
l
-galactopyranosylorientin, puerarin, trollisin I, rosmarinic acid, 2″-
O
-(2′″-methylbutanoyl) isoswertisin, daidzin, scutellarin, 3′-methoxy puerarin, vitexin, 3′-hydroxy puerarin, 2″-
O
-(2′″-methylbutanoyl) vitexin, kaempferol, caffeic acid, 3,4-dimethoxybenzoic acid, and cynaroside were determined as the major components of JD. This study provides a useful combinational method for analyzing the major pharmacodynamic substances of JD and lays a foundation for the quality control research of the decoction.</description><identifier>ISSN: 0009-5893</identifier><identifier>EISSN: 1612-1112</identifier><identifier>DOI: 10.1007/s10337-019-03806-w</identifier><identifier>PMID: 32214429</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analytical Chemistry ; bioactive properties ; caffeic acid ; Chemistry ; Chemistry and Materials Science ; Chromatography ; daidzin ; influenza ; kaempferol ; Laboratory Medicine ; mass spectrometry ; monitoring ; Oriental traditional medicine ; Original ; pharmacodynamics ; Pharmacology ; Pharmacy ; Proteomics ; Qualitative analysis ; Quality control ; Quantitative analysis ; Rosmarinic acid ; Severe acute respiratory syndrome ; ultra-performance liquid chromatography</subject><ispartof>Chromatographia, 2019, Vol.82 (12), p.1801-1825</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019.</rights><rights>2019© Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-4f90154e6645dbb96de80c3256ea41beab78945ec9b736bbb5c46173bf3cf5eb3</citedby><cites>FETCH-LOGICAL-c507t-4f90154e6645dbb96de80c3256ea41beab78945ec9b736bbb5c46173bf3cf5eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10337-019-03806-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10337-019-03806-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32214429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fang, Mingyue</creatorcontrib><creatorcontrib>Liu, Shuangyue</creatorcontrib><creatorcontrib>Wang, Qingqing</creatorcontrib><creatorcontrib>Gu, Xuan</creatorcontrib><creatorcontrib>Ding, Pengmin</creatorcontrib><creatorcontrib>Wang, Weihua</creatorcontrib><creatorcontrib>Ding, Yi</creatorcontrib><creatorcontrib>Liu, Junxiu</creatorcontrib><creatorcontrib>Wang, Rufeng</creatorcontrib><title>Qualitative and Quantitative Analysis of 24 Components in Jinlianhua Decoction by UPLC–MS/MS</title><title>Chromatographia</title><addtitle>Chromatographia</addtitle><addtitle>Chromatographia</addtitle><description>Jinlianhua Decoction (JD), composed of Flos Trollii, Herba Taraxaci, Folium Isatidis, Radix Puerariae Lobatae, and Folium Perillae in a ratio of 6:15:10:10:6, is a prescription for Fengwen which is a group of febrile diseases due to wind in Chinese medicine. It was originally used for the prevention and treatment of severe acute respiratory syndrome (SARS), and could also be used to treat influenza due to their common pathomechanism. To elucidate the unclear pharmacodynamic basis of JD, the LC-QExactive-MS system was used to qualitatively analyze its main components in this study. As a result, 89 compounds were identified and 24 important ones were selected thereby to further perform the simultaneous quantification in 8 batches of JD samples using LC-QTrap-MS with multiple reaction monitoring (MRM). Based on the qualitative and quantitative results in combination with the bioactivities reported, 16 compounds including orientin, 2″-
O
-β-
l
-galactopyranosylorientin, puerarin, trollisin I, rosmarinic acid, 2″-
O
-(2′″-methylbutanoyl) isoswertisin, daidzin, scutellarin, 3′-methoxy puerarin, vitexin, 3′-hydroxy puerarin, 2″-
O
-(2′″-methylbutanoyl) vitexin, kaempferol, caffeic acid, 3,4-dimethoxybenzoic acid, and cynaroside were determined as the major components of JD. This study provides a useful combinational method for analyzing the major pharmacodynamic substances of JD and lays a foundation for the quality control research of the decoction.</description><subject>Analytical Chemistry</subject><subject>bioactive properties</subject><subject>caffeic acid</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chromatography</subject><subject>daidzin</subject><subject>influenza</subject><subject>kaempferol</subject><subject>Laboratory Medicine</subject><subject>mass spectrometry</subject><subject>monitoring</subject><subject>Oriental traditional medicine</subject><subject>Original</subject><subject>pharmacodynamics</subject><subject>Pharmacology</subject><subject>Pharmacy</subject><subject>Proteomics</subject><subject>Qualitative analysis</subject><subject>Quality control</subject><subject>Quantitative analysis</subject><subject>Rosmarinic acid</subject><subject>Severe acute respiratory syndrome</subject><subject>ultra-performance liquid chromatography</subject><issn>0009-5893</issn><issn>1612-1112</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqNkcluFDEQhi0EIpPAC3BAlrhwaVLe2xekaNg1EaCQK5btcSeOeuxJuzvR3PIOvCFPgsMkYTkgTla5vvpr-RF6QuAFAVD7hQBjqgGiG2AtyObyHpoRSWhDCKH30QwAdCNazXbQbilnNaRayodoh1FKOKd6hr5-nmwfRzvGi4BtWuIap_H24yDZflNiwbnDlON5Xq1zCmksOCb8IaY-2nQ6Wfwq-OzHmBN2G3z8aTH_fvXt8Gj_8OgRetDZvoTHN-8eOn7z-sv8XbP4-Pb9_GDReAFqbHingQgepORi6ZyWy9CCZ1TIYDlxwTrVai6C104x6ZwTnkuimOuY70RwbA-93OquJ7cKS19nHGxv1kNc2WFjso3mz0yKp-YkXxgFbQsCqsDzG4Ehn0-hjGYViw99b1PIUzGUtZxCS0D9ByooZwwEr-izv9CzPA31qNcUISBBEVopuqX8kEsZQnc3NwFz7bTZOm2q0-an0-ayFj39feO7kltrK8C2QKmpdBKGX73_IfsDAD-1EA</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Fang, Mingyue</creator><creator>Liu, Shuangyue</creator><creator>Wang, Qingqing</creator><creator>Gu, Xuan</creator><creator>Ding, Pengmin</creator><creator>Wang, Weihua</creator><creator>Ding, Yi</creator><creator>Liu, Junxiu</creator><creator>Wang, Rufeng</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2019</creationdate><title>Qualitative and Quantitative Analysis of 24 Components in Jinlianhua Decoction by UPLC–MS/MS</title><author>Fang, Mingyue ; Liu, Shuangyue ; Wang, Qingqing ; Gu, Xuan ; Ding, Pengmin ; Wang, Weihua ; Ding, Yi ; Liu, Junxiu ; Wang, Rufeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-4f90154e6645dbb96de80c3256ea41beab78945ec9b736bbb5c46173bf3cf5eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Analytical Chemistry</topic><topic>bioactive properties</topic><topic>caffeic acid</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chromatography</topic><topic>daidzin</topic><topic>influenza</topic><topic>kaempferol</topic><topic>Laboratory Medicine</topic><topic>mass spectrometry</topic><topic>monitoring</topic><topic>Oriental traditional medicine</topic><topic>Original</topic><topic>pharmacodynamics</topic><topic>Pharmacology</topic><topic>Pharmacy</topic><topic>Proteomics</topic><topic>Qualitative analysis</topic><topic>Quality control</topic><topic>Quantitative analysis</topic><topic>Rosmarinic acid</topic><topic>Severe acute respiratory syndrome</topic><topic>ultra-performance liquid chromatography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fang, Mingyue</creatorcontrib><creatorcontrib>Liu, Shuangyue</creatorcontrib><creatorcontrib>Wang, Qingqing</creatorcontrib><creatorcontrib>Gu, Xuan</creatorcontrib><creatorcontrib>Ding, Pengmin</creatorcontrib><creatorcontrib>Wang, Weihua</creatorcontrib><creatorcontrib>Ding, Yi</creatorcontrib><creatorcontrib>Liu, Junxiu</creatorcontrib><creatorcontrib>Wang, Rufeng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chromatographia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fang, Mingyue</au><au>Liu, Shuangyue</au><au>Wang, Qingqing</au><au>Gu, Xuan</au><au>Ding, Pengmin</au><au>Wang, Weihua</au><au>Ding, Yi</au><au>Liu, Junxiu</au><au>Wang, Rufeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Qualitative and Quantitative Analysis of 24 Components in Jinlianhua Decoction by UPLC–MS/MS</atitle><jtitle>Chromatographia</jtitle><stitle>Chromatographia</stitle><addtitle>Chromatographia</addtitle><date>2019</date><risdate>2019</risdate><volume>82</volume><issue>12</issue><spage>1801</spage><epage>1825</epage><pages>1801-1825</pages><issn>0009-5893</issn><eissn>1612-1112</eissn><abstract>Jinlianhua Decoction (JD), composed of Flos Trollii, Herba Taraxaci, Folium Isatidis, Radix Puerariae Lobatae, and Folium Perillae in a ratio of 6:15:10:10:6, is a prescription for Fengwen which is a group of febrile diseases due to wind in Chinese medicine. It was originally used for the prevention and treatment of severe acute respiratory syndrome (SARS), and could also be used to treat influenza due to their common pathomechanism. To elucidate the unclear pharmacodynamic basis of JD, the LC-QExactive-MS system was used to qualitatively analyze its main components in this study. As a result, 89 compounds were identified and 24 important ones were selected thereby to further perform the simultaneous quantification in 8 batches of JD samples using LC-QTrap-MS with multiple reaction monitoring (MRM). Based on the qualitative and quantitative results in combination with the bioactivities reported, 16 compounds including orientin, 2″-
O
-β-
l
-galactopyranosylorientin, puerarin, trollisin I, rosmarinic acid, 2″-
O
-(2′″-methylbutanoyl) isoswertisin, daidzin, scutellarin, 3′-methoxy puerarin, vitexin, 3′-hydroxy puerarin, 2″-
O
-(2′″-methylbutanoyl) vitexin, kaempferol, caffeic acid, 3,4-dimethoxybenzoic acid, and cynaroside were determined as the major components of JD. This study provides a useful combinational method for analyzing the major pharmacodynamic substances of JD and lays a foundation for the quality control research of the decoction.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32214429</pmid><doi>10.1007/s10337-019-03806-w</doi><tpages>25</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analytical Chemistry bioactive properties caffeic acid Chemistry Chemistry and Materials Science Chromatography daidzin influenza kaempferol Laboratory Medicine mass spectrometry monitoring Oriental traditional medicine Original pharmacodynamics Pharmacology Pharmacy Proteomics Qualitative analysis Quality control Quantitative analysis Rosmarinic acid Severe acute respiratory syndrome ultra-performance liquid chromatography |
| title | Qualitative and Quantitative Analysis of 24 Components in Jinlianhua Decoction by UPLC–MS/MS |
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