Anti-tumor activity of an engineered decoy receptor targeting CLCF1-CNTFR signaling in lung adenocarcinoma

Pro-inflammatory cytokines in the tumor microenvironment (TME) can promote tumor growth, yet their value as therapeutic targets remains underexploited. We validated the functional significance of the CLCF1-CNTFR signaling axis in lung adenocarcinoma (LUAD) and generated a high affinity soluble recep...

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Veröffentlicht in:	Nature medicine 2019-11, Vol.25 (11), p.1783-1795
Hauptverfasser:	Kim, Jun W., Marquez, Cesar P., Kostyrko, Kaja, Koehne, Amanda L., Marini, Kieren, Simpson, David R., Lee, Alex G., Leung, Stanley G., Sayles, Leanne C., Shrager, Joseph, Ferrer, Irene, Paz-Ares, Luis, Gephart, Melanie Hayden, Vicent, Silvestre, Cochran, Jennifer R., Sweet-Cordero, E. Alejandro
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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