Cytomegalovirus-vectored vaccines for HIV and other pathogens
The use of cytomegalovirus (CMV) as a vaccine vector to express antigens against multiple infectious diseases, including simian immunodeficiency virus, Ebola virus, plasmodium, and mycobacterium tuberculosis, in rhesus macaques has generated extraordinary levels of protective immunity against subseq...
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| Veröffentlicht in: | AIDS (London) 2020-03, Vol.34 (3), p.335-349 |
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| container_title | AIDS (London) |
| container_volume | 34 |
| creator | Barry, Peter A. Deere, Jesse D. Yue, Yujuan Chang, William W.L. Schmidt, Kimberli A. Wussow, Felix Chiuppesi, Flavia Diamond, Don J. Sparger, Ellen E. Walter, Mark R. Hartigan-O’Connor, Dennis J. |
| description | The use of cytomegalovirus (CMV) as a vaccine vector to express antigens against multiple infectious diseases, including simian immunodeficiency virus, Ebola virus, plasmodium, and mycobacterium tuberculosis, in rhesus macaques has generated extraordinary levels of protective immunity against subsequent pathogenic challenge. Moreover, the mechanisms of immune protection have altered paradigms about viral vector-mediated immunity against ectopically expressed vaccine antigens. Further optimization of CMV-vectored vaccines, particularly as this approach moves to human clinical trials will be augmented by a more complete understanding of how CMV engenders mechanisms of immune protection. This review summarizes the particulars of the specific CMV vaccine vector that has been used to date (rhesus CMV strain 68-1) in relation to CMV natural history. |
| doi_str_mv | 10.1097/QAD.0000000000002396 |
| format | Article |
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Moreover, the mechanisms of immune protection have altered paradigms about viral vector-mediated immunity against ectopically expressed vaccine antigens. Further optimization of CMV-vectored vaccines, particularly as this approach moves to human clinical trials will be augmented by a more complete understanding of how CMV engenders mechanisms of immune protection. This review summarizes the particulars of the specific CMV vaccine vector that has been used to date (rhesus CMV strain 68-1) in relation to CMV natural history.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/QAD.0000000000002396</identifier><identifier>PMID: 31634191</identifier><language>eng</language><publisher>England: Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Animals ; Antibodies, Viral ; Cytomegalovirus - immunology ; Cytomegalovirus Vaccines ; Genetic Vectors ; HIV Infections - prevention & control ; Humans ; Macaca mulatta ; Simian Acquired Immunodeficiency Syndrome ; Simian Immunodeficiency Virus - immunology</subject><ispartof>AIDS (London), 2020-03, Vol.34 (3), p.335-349</ispartof><rights>Wolters Kluwer Health, Inc. 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Moreover, the mechanisms of immune protection have altered paradigms about viral vector-mediated immunity against ectopically expressed vaccine antigens. Further optimization of CMV-vectored vaccines, particularly as this approach moves to human clinical trials will be augmented by a more complete understanding of how CMV engenders mechanisms of immune protection. This review summarizes the particulars of the specific CMV vaccine vector that has been used to date (rhesus CMV strain 68-1) in relation to CMV natural history.</description><subject>Animals</subject><subject>Antibodies, Viral</subject><subject>Cytomegalovirus - immunology</subject><subject>Cytomegalovirus Vaccines</subject><subject>Genetic Vectors</subject><subject>HIV Infections - prevention & control</subject><subject>Humans</subject><subject>Macaca mulatta</subject><subject>Simian Acquired Immunodeficiency Syndrome</subject><subject>Simian Immunodeficiency Virus - immunology</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP5DAQhC20CIbHP0Aox70E2rHjx2GR0OzykJAQEnC1HKczCZuJZ-1kEP-eDAMIOCx9Kan9VblVhBxQOKKg5fHN6e8j-DAZ02KDTCiXLM1zSX-QCWRCp5pJ2CY7MT6MUA5KbZFtRgXjVNMJ-TV96v0cZ7b1yyYMMV2i633AMlla55oOY1L5kFxc3ie2KxPf1xiShe1rP8Mu7pHNyrYR9191l9yd_bmdXqRX1-eX09Or1OXjDWlRqEIoXSglpKPcaVHkHHOFIChwkDwTJRPCskLS0gmpLaLDyglX5a7UwHbJyTp3MRRzLB12fbCtWYRmbsOT8bYxn1-6pjYzvzQSlGT5KuDna0Dw_waMvZk30WHb2g79EE3GQEoOOmMjyteoCz7GgNX7NxTMqnkzNm--Nj_aDj-e-G56q3oE1Bp49G2PIf5th0cMpkbb9vV32fw_1hcMGKTZKKNSSFcryp4Bwnif5w</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Barry, Peter A.</creator><creator>Deere, Jesse D.</creator><creator>Yue, Yujuan</creator><creator>Chang, William W.L.</creator><creator>Schmidt, Kimberli A.</creator><creator>Wussow, Felix</creator><creator>Chiuppesi, Flavia</creator><creator>Diamond, Don J.</creator><creator>Sparger, Ellen E.</creator><creator>Walter, Mark R.</creator><creator>Hartigan-O’Connor, Dennis J.</creator><general>Wolters Kluwer Health, Inc. 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| ispartof | AIDS (London), 2020-03, Vol.34 (3), p.335-349 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Antibodies, Viral Cytomegalovirus - immunology Cytomegalovirus Vaccines Genetic Vectors HIV Infections - prevention & control Humans Macaca mulatta Simian Acquired Immunodeficiency Syndrome Simian Immunodeficiency Virus - immunology |
| title | Cytomegalovirus-vectored vaccines for HIV and other pathogens |
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