Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication
In this study, we demonstrate that infection of HSB-2 cells with human herpesvirus 6 (HHV-6) resulted in the accumulation of infected cells in the G2/M phase of the cell cycle. Analysis of various cell-cycle-regulatory proteins indicated that the levels of cyclins A2, B1, and E1 were increased in HH...
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| Veröffentlicht in: | Archives of virology 2014-02, Vol.159 (2), p.365-370 |
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| container_title | Archives of virology |
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| creator | Li, Lingyun Gu, Bin Zhou, Feng Chi, Jing Feng, Dongju Xie, Fangyi Wang, Fang Ma, Changyan Li, Meng Wang, Jinfeng Yao, Kun |
| description | In this study, we demonstrate that infection of HSB-2 cells with human herpesvirus 6 (HHV-6) resulted in the accumulation of infected cells in the G2/M phase of the cell cycle. Analysis of various cell-cycle-regulatory proteins indicated that the levels of cyclins A2, B1, and E1 were increased in HHV-6-infected cells, but there was no difference in cyclin D1 levels between mock-infected and HHV-6-infected cells. Our data also showed that inducing G2/M phase arrest in cells infected by HHV-6 provided favorable conditions for viral replication. |
| doi_str_mv | 10.1007/s00705-013-1826-0 |
| format | Article |
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Analysis of various cell-cycle-regulatory proteins indicated that the levels of cyclins A2, B1, and E1 were increased in HHV-6-infected cells, but there was no difference in cyclin D1 levels between mock-infected and HHV-6-infected cells. Our data also showed that inducing G2/M phase arrest in cells infected by HHV-6 provided favorable conditions for viral replication.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-013-1826-0</identifier><identifier>PMID: 24013234</identifier><language>eng</language><publisher>Vienna: Springer-Verlag</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Brief Report ; Cell Cycle ; Cell Cycle Proteins - analysis ; Cell Line ; Chronic fatigue syndrome ; cyclins ; Genomes ; Herpes viruses ; Herpesvirus 6, Human - physiology ; Host-Pathogen Interactions ; Human herpesvirus 6 ; Humans ; Infections ; Infectious Diseases ; Medical Microbiology ; Monoclonal antibodies ; Protein expression ; Proteins ; T-Lymphocytes - physiology ; T-Lymphocytes - virology ; Virology ; Virus Replication</subject><ispartof>Archives of virology, 2014-02, Vol.159 (2), p.365-370</ispartof><rights>Springer-Verlag Wien 2013</rights><rights>Springer-Verlag Wien 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-754f4b3ad4331d1d85fe3750b8df868248b3774c1ad573277a639a85f6e2ae1e3</citedby><cites>FETCH-LOGICAL-c494t-754f4b3ad4331d1d85fe3750b8df868248b3774c1ad573277a639a85f6e2ae1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00705-013-1826-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00705-013-1826-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24013234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Lingyun</creatorcontrib><creatorcontrib>Gu, Bin</creatorcontrib><creatorcontrib>Zhou, Feng</creatorcontrib><creatorcontrib>Chi, Jing</creatorcontrib><creatorcontrib>Feng, Dongju</creatorcontrib><creatorcontrib>Xie, Fangyi</creatorcontrib><creatorcontrib>Wang, Fang</creatorcontrib><creatorcontrib>Ma, Changyan</creatorcontrib><creatorcontrib>Li, Meng</creatorcontrib><creatorcontrib>Wang, Jinfeng</creatorcontrib><creatorcontrib>Yao, Kun</creatorcontrib><title>Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><addtitle>Arch Virol</addtitle><description>In this study, we demonstrate that infection of HSB-2 cells with human herpesvirus 6 (HHV-6) resulted in the accumulation of infected cells in the G2/M phase of the cell cycle. Analysis of various cell-cycle-regulatory proteins indicated that the levels of cyclins A2, B1, and E1 were increased in HHV-6-infected cells, but there was no difference in cyclin D1 levels between mock-infected and HHV-6-infected cells. Our data also showed that inducing G2/M phase arrest in cells infected by HHV-6 provided favorable conditions for viral replication.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brief Report</subject><subject>Cell Cycle</subject><subject>Cell Cycle Proteins - analysis</subject><subject>Cell Line</subject><subject>Chronic fatigue syndrome</subject><subject>cyclins</subject><subject>Genomes</subject><subject>Herpes viruses</subject><subject>Herpesvirus 6, Human - physiology</subject><subject>Host-Pathogen Interactions</subject><subject>Human herpesvirus 6</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious Diseases</subject><subject>Medical Microbiology</subject><subject>Monoclonal antibodies</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>T-Lymphocytes - physiology</subject><subject>T-Lymphocytes - virology</subject><subject>Virology</subject><subject>Virus Replication</subject><issn>0304-8608</issn><issn>1432-8798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kk1P3DAQhq2KqizQH9BLscSFS4q_EjsXJLTql4TEAThbjj3ZNco6qZ0g7b_HIRRBD73Y0swz78z4NUJfKPlGCZEXKR-kLAjlBVWsKsgHtKKCs0LJWh2gFeFEFKoi6hAdpfRASA7w8hM6ZCLXMC5WaLOGrsN2bzvAA8Rxio0ZfR8S9sFNFhxu9ng77UzAW4gDpEcfp4SrnG7BziQ2weFxCz5iaOcYzrGFijB03j7rnaCPrekSfH65j9H9j-9361_F9c3P3-ur68KKWoyFLEUrGm6c4Jw66lTZApclaZRrVaWYUA2XUlhqXCk5k9JUvDaZqoAZoMCP0eWiO0zNDpyFMEbT6SH6nYl73Ruv32eC3-pN_6glUVUtSBY4fxGI_Z8J0qh3Ptn8SCZAPyVNRc1lLSmXGT37B33opxjyejPFhCBMqUzRhbKxTylC-zoMJXq2US826myJnm3U8xBf327xWvHXtwywBUg5FTYQ37T-j-rpUtSaXptN9Enf3zJCRf4YlGeIPwEjULJS</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Li, Lingyun</creator><creator>Gu, Bin</creator><creator>Zhou, Feng</creator><creator>Chi, Jing</creator><creator>Feng, Dongju</creator><creator>Xie, Fangyi</creator><creator>Wang, Fang</creator><creator>Ma, Changyan</creator><creator>Li, Meng</creator><creator>Wang, Jinfeng</creator><creator>Yao, Kun</creator><general>Springer-Verlag</general><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140201</creationdate><title>Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication</title><author>Li, Lingyun ; Gu, Bin ; Zhou, Feng ; Chi, Jing ; Feng, Dongju ; Xie, Fangyi ; Wang, Fang ; Ma, Changyan ; Li, Meng ; Wang, Jinfeng ; Yao, Kun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-754f4b3ad4331d1d85fe3750b8df868248b3774c1ad573277a639a85f6e2ae1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brief Report</topic><topic>Cell Cycle</topic><topic>Cell Cycle Proteins - analysis</topic><topic>Cell Line</topic><topic>Chronic fatigue syndrome</topic><topic>cyclins</topic><topic>Genomes</topic><topic>Herpes viruses</topic><topic>Herpesvirus 6, Human - physiology</topic><topic>Host-Pathogen Interactions</topic><topic>Human herpesvirus 6</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious Diseases</topic><topic>Medical Microbiology</topic><topic>Monoclonal antibodies</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>T-Lymphocytes - physiology</topic><topic>T-Lymphocytes - virology</topic><topic>Virology</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Lingyun</creatorcontrib><creatorcontrib>Gu, Bin</creatorcontrib><creatorcontrib>Zhou, Feng</creatorcontrib><creatorcontrib>Chi, Jing</creatorcontrib><creatorcontrib>Feng, Dongju</creatorcontrib><creatorcontrib>Xie, Fangyi</creatorcontrib><creatorcontrib>Wang, Fang</creatorcontrib><creatorcontrib>Ma, Changyan</creatorcontrib><creatorcontrib>Li, Meng</creatorcontrib><creatorcontrib>Wang, Jinfeng</creatorcontrib><creatorcontrib>Yao, Kun</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Lingyun</au><au>Gu, Bin</au><au>Zhou, Feng</au><au>Chi, Jing</au><au>Feng, Dongju</au><au>Xie, Fangyi</au><au>Wang, Fang</au><au>Ma, Changyan</au><au>Li, Meng</au><au>Wang, Jinfeng</au><au>Yao, Kun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication</atitle><jtitle>Archives of virology</jtitle><stitle>Arch Virol</stitle><addtitle>Arch Virol</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>159</volume><issue>2</issue><spage>365</spage><epage>370</epage><pages>365-370</pages><issn>0304-8608</issn><eissn>1432-8798</eissn><abstract>In this study, we demonstrate that infection of HSB-2 cells with human herpesvirus 6 (HHV-6) resulted in the accumulation of infected cells in the G2/M phase of the cell cycle. Analysis of various cell-cycle-regulatory proteins indicated that the levels of cyclins A2, B1, and E1 were increased in HHV-6-infected cells, but there was no difference in cyclin D1 levels between mock-infected and HHV-6-infected cells. Our data also showed that inducing G2/M phase arrest in cells infected by HHV-6 provided favorable conditions for viral replication.</abstract><cop>Vienna</cop><pub>Springer-Verlag</pub><pmid>24013234</pmid><doi>10.1007/s00705-013-1826-0</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Archives of virology, 2014-02, Vol.159 (2), p.365-370 |
| issn | 0304-8608 1432-8798 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Biomedical and Life Sciences Biomedicine Brief Report Cell Cycle Cell Cycle Proteins - analysis Cell Line Chronic fatigue syndrome cyclins Genomes Herpes viruses Herpesvirus 6, Human - physiology Host-Pathogen Interactions Human herpesvirus 6 Humans Infections Infectious Diseases Medical Microbiology Monoclonal antibodies Protein expression Proteins T-Lymphocytes - physiology T-Lymphocytes - virology Virology Virus Replication |
| title | Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication |
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