A miR-146a-5p/TRAF6/NF-kB p65 axis regulates pancreatic cancer chemoresistance: functional validation and clinical significance

: Dysregulated microRNA (miRNA) expression in cancer can act as a key factor that modifies biological processes, including chemoresistance. Our study aimed to identify the miRNAs associated with gemcitabine (GEM) resistance in pancreatic ductal adenocarcinoma (PDAC) and to explore the potential mech...

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Veröffentlicht in:	Theranostics 2020-01, Vol.10 (9), p.3967-3979
Hauptverfasser:	Meng, Qingcai, Liang, Chen, Hua, Jie, Zhang, Bo, Liu, Jiang, Zhang, Yiyin, Wei, Miaoyan, Yu, Xianjun, Xu, Jin, Shi, Si
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Apoptosis Cancer therapies Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - metabolism Cell growth Cell Line, Tumor Cell Proliferation Clinical significance Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Glycoproteins Humans Intracellular Signaling Peptides and Proteins - metabolism Kinases Laboratory animals Medical prognosis Medical research Mice Mice, Inbred BALB C Mice, Nude MicroRNAs MicroRNAs - physiology Mutagenesis Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Protein expression Proteins Reagents Research Paper Software Survival analysis Transcription Factor RelA - metabolism Tumorigenesis Tumors
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