Identification of Key Gene and Pathways for the Prediction of Peritoneal Metastasis of Gastric Cancer by Co-expression Analysis
Peritoneal metastasis is the most common pattern in advanced gastric cancer and can predict poor disease prognosis. Early detection of peritoneal tumor dissemination is restricted by small peritoneal deposits. Therefore, it is critical to identify a novel predictive marker and to explore the potenti...
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| Veröffentlicht in: | Journal of Cancer 2020-01, Vol.11 (10), p.3041-3051 |
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| creator | Zhang, Simeng Zang, Dan Cheng, Yu Li, Zhi Yang, Bowen Guo, Tianshu Liu, Yunpeng Qu, Xiujuan Che, Xiaofang |
| description | Peritoneal metastasis is the most common pattern in advanced gastric cancer and can predict poor disease prognosis. Early detection of peritoneal tumor dissemination is restricted by small peritoneal deposits. Therefore, it is critical to identify a novel predictive marker and to explore the potential mechanism associated with this process. In the present study, one module that correlated with peritoneal metastasis was identified. Enrichment analysis indicated that the Focal adhesion and the PI3K-Akt signaling pathway were the most significant pathways. Following network and Molecular Complex Detection (MCODE) analysis, the hub-gene cluster that consisted of 19 genes was selected. Methionine sulfoxide reductase B3 (
) was identified as a seed gene. Survival analysis indicated that high expression levels of
were independent predictors of peritoneal disease-free survival (pDFS) as determined by univariate (HR 8.559, 95% CI; 3.339-21.937; P |
| doi_str_mv | 10.7150/jca.39645 |
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) was identified as a seed gene. Survival analysis indicated that high expression levels of
were independent predictors of peritoneal disease-free survival (pDFS) as determined by univariate (HR 8.559, 95% CI; 3.339-21.937; P<.001) and multivariate Cox analysis (HR 3.982, 95% CI; 1.509-10.509; P=.005). Furthermore, patients with high levels of
exhibited a significantly lower Overall Survival (OS) (log-rank P = 0.007). The external validation was performed by the (The Cancer Genome Atlas (TCGA)) (log-rank P = 0.037) and Kaplan Meier-plotter (KMplotter) (log-rank P = 0.031) data.
experiments confirmed that MSRB3 was a critical protein in regulating gastric cancer cell proliferation and migration. In conclusion, High expression levels of
in GC can predict peritoneal metastasis and recurrence as well as poor prognosis. Furthermore,
was involved in the regulation of the proliferation and migration of GC cells.</description><identifier>ISSN: 1837-9664</identifier><identifier>EISSN: 1837-9664</identifier><identifier>DOI: 10.7150/jca.39645</identifier><identifier>PMID: 32226519</identifier><language>eng</language><publisher>Australia: Ivyspring International Publisher Pty Ltd</publisher><subject>Antibodies ; Gastric cancer ; Gene expression ; Kinases ; Medical prognosis ; Metastasis ; Proteins ; Research Paper ; Software ; Survival analysis</subject><ispartof>Journal of Cancer, 2020-01, Vol.11 (10), p.3041-3051</ispartof><rights>The author(s).</rights><rights>2020. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-79eb1f90d257215d6e2717eb3ccfc16ec96d2dafc1a4cc5289c07a70cab3fc213</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086253/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086253/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32226519$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Simeng</creatorcontrib><creatorcontrib>Zang, Dan</creatorcontrib><creatorcontrib>Cheng, Yu</creatorcontrib><creatorcontrib>Li, Zhi</creatorcontrib><creatorcontrib>Yang, Bowen</creatorcontrib><creatorcontrib>Guo, Tianshu</creatorcontrib><creatorcontrib>Liu, Yunpeng</creatorcontrib><creatorcontrib>Qu, Xiujuan</creatorcontrib><creatorcontrib>Che, Xiaofang</creatorcontrib><title>Identification of Key Gene and Pathways for the Prediction of Peritoneal Metastasis of Gastric Cancer by Co-expression Analysis</title><title>Journal of Cancer</title><addtitle>J Cancer</addtitle><description>Peritoneal metastasis is the most common pattern in advanced gastric cancer and can predict poor disease prognosis. Early detection of peritoneal tumor dissemination is restricted by small peritoneal deposits. Therefore, it is critical to identify a novel predictive marker and to explore the potential mechanism associated with this process. In the present study, one module that correlated with peritoneal metastasis was identified. Enrichment analysis indicated that the Focal adhesion and the PI3K-Akt signaling pathway were the most significant pathways. Following network and Molecular Complex Detection (MCODE) analysis, the hub-gene cluster that consisted of 19 genes was selected. Methionine sulfoxide reductase B3 (
) was identified as a seed gene. Survival analysis indicated that high expression levels of
were independent predictors of peritoneal disease-free survival (pDFS) as determined by univariate (HR 8.559, 95% CI; 3.339-21.937; P<.001) and multivariate Cox analysis (HR 3.982, 95% CI; 1.509-10.509; P=.005). Furthermore, patients with high levels of
exhibited a significantly lower Overall Survival (OS) (log-rank P = 0.007). The external validation was performed by the (The Cancer Genome Atlas (TCGA)) (log-rank P = 0.037) and Kaplan Meier-plotter (KMplotter) (log-rank P = 0.031) data.
experiments confirmed that MSRB3 was a critical protein in regulating gastric cancer cell proliferation and migration. In conclusion, High expression levels of
in GC can predict peritoneal metastasis and recurrence as well as poor prognosis. Furthermore,
was involved in the regulation of the proliferation and migration of GC cells.</description><subject>Antibodies</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Kinases</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Proteins</subject><subject>Research Paper</subject><subject>Software</subject><subject>Survival analysis</subject><issn>1837-9664</issn><issn>1837-9664</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkU1v1DAQhi1ERau2B_4AssQFDin-SOz4glStYKlo1T3A2XImE9arrL3YWSAn_jpe-qGCNZJfaZ55NaOXkJecXWjesHcbcBfSqLp5Rk54K3VllKqfP9HH5DznDStPGqFr-YIcSyGEarg5Ib-vegyTHzy4ycdA40A_40yXGJC60NOVm9Y_3ZzpEBOd1khXCXsPD-wKk59iQDfSG5xcLuXzobEsOnmgCxcAE-1muogV_tolzPkwexncOBf2jBwNbsx4fv-fkq8fP3xZfKqub5dXi8vrCmomp0ob7PhgWC8aLXjTKxSaa-wkwABcIRjVi94V7WqARrQGmHaagevkAILLU_L-zne377bYQzk6udHukt-6NNvovP23E_zafos_rGatEo0sBm_uDVL8vsc82a3PgOPoAsZ9tkK2dVsXUhT09X_oJu5TObhQjWllrTirC_X2joIUc044PC7DmT0ka0uy9m-yhX31dPtH8iFH-Qcs2qDO</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Zhang, Simeng</creator><creator>Zang, Dan</creator><creator>Cheng, Yu</creator><creator>Li, Zhi</creator><creator>Yang, Bowen</creator><creator>Guo, Tianshu</creator><creator>Liu, Yunpeng</creator><creator>Qu, Xiujuan</creator><creator>Che, Xiaofang</creator><general>Ivyspring International Publisher Pty Ltd</general><general>Ivyspring International Publisher</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200101</creationdate><title>Identification of Key Gene and Pathways for the Prediction of Peritoneal Metastasis of Gastric Cancer by Co-expression Analysis</title><author>Zhang, Simeng ; Zang, Dan ; Cheng, Yu ; Li, Zhi ; Yang, Bowen ; Guo, Tianshu ; Liu, Yunpeng ; Qu, Xiujuan ; Che, Xiaofang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-79eb1f90d257215d6e2717eb3ccfc16ec96d2dafc1a4cc5289c07a70cab3fc213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibodies</topic><topic>Gastric cancer</topic><topic>Gene expression</topic><topic>Kinases</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Proteins</topic><topic>Research Paper</topic><topic>Software</topic><topic>Survival analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Simeng</creatorcontrib><creatorcontrib>Zang, Dan</creatorcontrib><creatorcontrib>Cheng, Yu</creatorcontrib><creatorcontrib>Li, Zhi</creatorcontrib><creatorcontrib>Yang, Bowen</creatorcontrib><creatorcontrib>Guo, Tianshu</creatorcontrib><creatorcontrib>Liu, Yunpeng</creatorcontrib><creatorcontrib>Qu, Xiujuan</creatorcontrib><creatorcontrib>Che, Xiaofang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Simeng</au><au>Zang, Dan</au><au>Cheng, Yu</au><au>Li, Zhi</au><au>Yang, Bowen</au><au>Guo, Tianshu</au><au>Liu, Yunpeng</au><au>Qu, Xiujuan</au><au>Che, Xiaofang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of Key Gene and Pathways for the Prediction of Peritoneal Metastasis of Gastric Cancer by Co-expression Analysis</atitle><jtitle>Journal of Cancer</jtitle><addtitle>J Cancer</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>11</volume><issue>10</issue><spage>3041</spage><epage>3051</epage><pages>3041-3051</pages><issn>1837-9664</issn><eissn>1837-9664</eissn><abstract>Peritoneal metastasis is the most common pattern in advanced gastric cancer and can predict poor disease prognosis. Early detection of peritoneal tumor dissemination is restricted by small peritoneal deposits. Therefore, it is critical to identify a novel predictive marker and to explore the potential mechanism associated with this process. In the present study, one module that correlated with peritoneal metastasis was identified. Enrichment analysis indicated that the Focal adhesion and the PI3K-Akt signaling pathway were the most significant pathways. Following network and Molecular Complex Detection (MCODE) analysis, the hub-gene cluster that consisted of 19 genes was selected. Methionine sulfoxide reductase B3 (
) was identified as a seed gene. Survival analysis indicated that high expression levels of
were independent predictors of peritoneal disease-free survival (pDFS) as determined by univariate (HR 8.559, 95% CI; 3.339-21.937; P<.001) and multivariate Cox analysis (HR 3.982, 95% CI; 1.509-10.509; P=.005). Furthermore, patients with high levels of
exhibited a significantly lower Overall Survival (OS) (log-rank P = 0.007). The external validation was performed by the (The Cancer Genome Atlas (TCGA)) (log-rank P = 0.037) and Kaplan Meier-plotter (KMplotter) (log-rank P = 0.031) data.
experiments confirmed that MSRB3 was a critical protein in regulating gastric cancer cell proliferation and migration. In conclusion, High expression levels of
in GC can predict peritoneal metastasis and recurrence as well as poor prognosis. Furthermore,
was involved in the regulation of the proliferation and migration of GC cells.</abstract><cop>Australia</cop><pub>Ivyspring International Publisher Pty Ltd</pub><pmid>32226519</pmid><doi>10.7150/jca.39645</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antibodies Gastric cancer Gene expression Kinases Medical prognosis Metastasis Proteins Research Paper Software Survival analysis |
| title | Identification of Key Gene and Pathways for the Prediction of Peritoneal Metastasis of Gastric Cancer by Co-expression Analysis |
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